Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Yoshiko Fukuyama"'
Autor:
Yoshiko Fukuyama, Kazunari Okada, Masahiro Yamaguchi, Hiroshi Kiyono, Kensaku Mori, Yoshikazu Yuki
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139368 (2015)
Cholera toxin (CT) induces severe diarrhea in humans but acts as an adjuvant to enhance immune responses to vaccines when administered orally. Nasally administered CT also acts as an adjuvant, but CT and CT derivatives, including the B subunit of CT
Externí odkaz:
https://doaj.org/article/673e42c6d1fd4215a93e1045cf013b4b
Autor:
Yoshiko Fukuyama, Daisuke Tokuhara, Shinichi Sekine, Kazuyoshi Aso, Kosuke Kataoka, Julia Davydova, Masato Yamamoto, Rebekah S Gilbert, Yuka Tokuhara, Keiko Fujihashi, Jun Kunisawa, Yoshikazu Yuki, Hiroshi Kiyono, Jerry R McGhee, Kohtaro Fujihashi
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60453 (2013)
We assessed the role of CCR5(+)/CCR6(+)/CD11b(+)/CD11c(+) dendritic cells (DCs) for induction of ovalbumin (OVA)-specific antibody (Ab) responses following mucosal immunization. Mice given nasal OVA plus an adenovirus expressing Flt3 ligand (Ad-FL) s
Externí odkaz:
https://doaj.org/article/e67de8f7dd71445d98a0c9996ed96c13
Autor:
Kosuke Kataoka, Keiko Fujihashi, Yutaka Terao, Rebekah S Gilbert, Shinichi Sekine, Ryoki Kobayashi, Yoshiko Fukuyama, Shigetada Kawabata, Kohtaro Fujihashi
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25396 (2011)
Native cholera toxin (nCT) as a nasal adjuvant was shown to elicit increased levels of T-independent S-IgA antibody (Ab) responses through IL-5- IL-5 receptor interactions between CD4+ T cells and IgA+ B-1 B cells in murine submandibular glands (SMGs
Externí odkaz:
https://doaj.org/article/81971d897f2d44bf95fb5da06c944d96
Publikováno v:
Microbiology and Immunology. 61:195-205
In order to develop safe vaccines for effective mucosal immunity to major pulmonary bacterial infections, one must consider appropriate vaccine antigens (Ags), delivery systems and nontoxic molecular adjuvants. Such vaccine constructs can induce Ag-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd2892f77cc7bc62708754aa84203ad
https://doi.org/10.1111/1348-0421.12487
https://doi.org/10.1111/1348-0421.12487
Autor:
David E. Briles, Kazunari Akiyoshi, Yoshikazu Yuki, Haruko Takahashi, Hideo Tsukada, Shiho Kurokawa, Norihiro Harada, Shigeo Takeda, Hiroshi Kiyono, Mio Mejima, Yasuhiro Yasutomi, H Shibata, Shin-ichi Sawada, Kohtaro Fujihashi, Yuko Katakai, Sunyi Joo, Yoshiko Fukuyama, Eun Jeong Park
Publikováno v:
Mucosal Immunology
We previously established a nanosized nasal vaccine delivery system by using a cationic cholesteryl group-bearing pullulan nanogel (cCHP nanogel), which is a universal protein-based antigen-delivery vehicle for adjuvant-free nasal vaccination. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045b7febace6d170a4e685f9d8fd564b
https://doi.org/10.1038/mi.2015.5
https://doi.org/10.1038/mi.2015.5
Autor:
Kazuyoshi Aso, Yoshiko Fukuyama, David E. Briles, Jerry R. McGhee, Gen Sugita, Kohtaro Fujihashi, Yorihiko Ikeda, Junichiro Ohori, K Fujihashi
Publikováno v:
Immune Network
Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective mucosal immunity against this pathogen in order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8f3f6a78d6584cced9f92e9688c6ed
http://europepmc.org/articles/PMC4338268
http://europepmc.org/articles/PMC4338268
Publikováno v:
Microbiology and immunology. 61(6)
In order to develop safe vaccines for effective mucosal immunity to major pulmonary bacterial infections, one must consider appropriate vaccine antigens (Ags), delivery systems and nontoxic molecular adjuvants. Such vaccine constructs can induce Ag-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa23c5039cf20a21147c49390653da2d
https://pubmed.ncbi.nlm.nih.gov/28463465
https://pubmed.ncbi.nlm.nih.gov/28463465
Autor:
Natsumi Takeyama, Yoshikazu Yuki, Koji Kashima, Hiroshi Kiyono, Masaharu Kuroda, Yoshiko Fukuyama, Mio Mejima, Kimiko Itoh, Toshiaki Mitsui, Shiho Kurokawa
Publikováno v:
Plant Cell, Tissue and Organ Culture (PCTOC). 120:35-48
We previously developed a molecularly uniform rice-based oral cholera vaccine (MucoRice-CTB) by using an overexpression system for modified cholera toxin B-subunit, CTB (N4Q) with RNAi to suppress production of the major rice endogenous storage prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9ee332451a72afc4fc2499d67fbb34
https://doi.org/10.1007/s11240-014-0575-4
https://doi.org/10.1007/s11240-014-0575-4
Autor:
Yoshiko Fukuyama, Hiroshi Kiyono, Steven F. Ziegler, Yoshikazu Yuki, R Ouchida, Sunyi Joo, Eun Jeong Park, Yosuke Kurashima
Publikováno v:
Mucosal immunology. 10(4)
Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7)-like cytokine involved in T helper 2 type immune responses. The primary target of TSLP is myeloid dendritic cells (DCs), however, little is known about the mechanism by which TSLP elicits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6e950e02bd4102aebfc8b9c9b8fdea
https://pubmed.ncbi.nlm.nih.gov/27924821
https://pubmed.ncbi.nlm.nih.gov/27924821
Autor:
Yoshiko Fukuyama, Grace H. Moon, Julia Davydova, Kosuke Kataoka, Jonathan D. Markham, Yuka Tokuhara, Daisuke Tokuhara, K Fujihashi, Masato Yamamoto, Kohtaro Fujihashi, Rebekah S. Gilbert, Allyson R. Irwin, Shinichi Sekine
Publikováno v:
Biochemical and Biophysical Research Communications. 418:6-11
Our previous studies showed that an adenovirus (Ad) serotype 5 vector expressing Flt3 ligand (Ad-FL) as nasal adjuvant activates CD11c(+) dendritic cells (DCs) for the enhancement of antigen (Ag)-specific IgA antibody (Ab) responses. In this study, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::569c46f2ca1c4332748c6a5ad2bea508
https://doi.org/10.1016/j.bbrc.2011.12.046
https://doi.org/10.1016/j.bbrc.2011.12.046