Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Yoshiki Takamatsu"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 112-117 (2021)
Recent study suggests that protofibril-formation of amyloidogenic proteins (APs) might be involved in evolvability, an epigenetic inheritance of multiple stresses, in various biological systems. In cancer, evolvability of multiple APs, such as p53,
Externí odkaz:
https://doaj.org/article/3b39d8d0952d4d0fa20cc733f88bf011
Publikováno v:
Parkinson's Disease, Vol 2021 (2021)
The majority of Parkinson’s disease (PD) is sporadic in elderly and is characterized by α-synuclein (αS) aggregation and other alterations involving mitochondria, ubiquitin-proteasome, and autophagy. The remaining are familial PD associated with
Externí odkaz:
https://doaj.org/article/4e5eb9f569164b288ea282fc507a2c5c
Autor:
Gilbert Ho, Yoshiki Takamatsu, Ryoko Wada, Shuei Sugama, Masaaki Waragai, Takato Takenouchi, Eliezer Masliah, Makoto Hashimoto
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Type 2 diabetes mellitus (T2DM) has been clearlylinked to oxidative stress and amylin amyloidosis in pancreatic β-cells. Yet despite extensive investigation, the biological significance of this is not fully understood. Recently, we proposed that Alz
Externí odkaz:
https://doaj.org/article/917dfbee048349b59878644716b8b107
Autor:
Masaaki Waragai, Gilbert Ho, Yoshiki Takamatsu, Ryoko Wada, Shuei Sugama, Takato Takenouchi, Eliezer Masliah, Makoto Hashimoto
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Adiponectin (APN) is a multi-functional adipokine which sensitizes the insulin signals, stimulates mitochondria biogenesis, and suppresses inflammation. By virtue of these beneficial properties, APN may protect against metabolic syndrome, including o
Externí odkaz:
https://doaj.org/article/dfe452ef9b6a46d69ba5e781d4fcc964
Autor:
Yoshiki Takamatsu, Gilbert Ho, Wakako Koike, Shuei Sugama, Takato Takenouchi, Masaaki Waragai, Jianshe Wei, Kazunari Sekiyama, Makoto Hashimoto
Publikováno v:
npj Parkinson's Disease, Vol 3, Iss 1, Pp 1-10 (2017)
Abstract Protein aggregation is a pathological hallmark of and may play a central role in the neurotoxicity in age-associated neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Accordingly, inhibiting aggregation of
Externí odkaz:
https://doaj.org/article/bc8a805344ac428e9accaa32a0c1f422
Autor:
Masayo Fujita, Yoko Hagino, Yukio Takamatsu, Yuka Shimizu, Yoshiki Takamatsu, Kazutaka Ikeda, Makoto Hashimoto
Publikováno v:
Neuropsychopharmacology Reports, Vol 38, Iss 2, Pp 95-97 (2018)
Abstract Aim We previously generated transgenic (Tg) mice that expressed P123H β‐synuclein (βS), a dementia with Lewy body‐linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor
Externí odkaz:
https://doaj.org/article/9364aa784d8e4ed2a75400fc1c926ac1
Autor:
Jianshe Wei, Yoshiki Takamatsu, Ryoko Wada, Masayo Fujita, Gilbert Ho, Eliezer Masliah, Makoto Hashimoto
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 289 (2021)
Gaucher disease (GD), the most common lysosomal storage disorder (LSD), is caused by autosomal recessive mutations of the glucocerebrosidase gene, GBA1. In the majority of cases, GD has a non-neuropathic chronic form with adult onset (GD1), while oth
Externí odkaz:
https://doaj.org/article/a14a9b2544544c2ebbcc73814e73afb3
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2849 (2020)
Dementia with Lewy bodies (DLB) is the second most prevalent neurodegenerative dementia after Alzheimer’s disease, and is pathologically characterized by formation of intracellular inclusions called Lewy bodies, the major constituent of which is ag
Externí odkaz:
https://doaj.org/article/1b52aa55fdbb4b09882c75f2acd7ccf6
Autor:
Yoshiki Takamatsu, Masayo Fujita, Gilbert J. Ho, Ryoko Wada, Shuei Sugama, Takato Takenouchi, Masaaki Waragai, Eliezer Masliah, Makoto Hashimoto
Publikováno v:
Parkinson's Disease, Vol 2018 (2018)
Lewy body diseases, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), are associated with a wide range of nonmotor symptoms (NMS), including cognitive impairment, depression and anxiety, sleep dis
Externí odkaz:
https://doaj.org/article/d2607008c6b54a669ae5af79954ac3f5
Publikováno v:
Biomolecules, Vol 5, Iss 2, Pp 1000-1011 (2015)
Axonal swellings are histological hallmarks of axonopathies in various types of disorders in the central nervous system, including neurodegenerative diseases. Given the pivotal role of axonopathies during the early phase of neurodegenerative process,
Externí odkaz:
https://doaj.org/article/89141edc7b1e4788af2bd8e58c40ebc5