Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Yoshiki, Sasai"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The neuroectoderm is patterned in a rostral-caudal axis in the embryo but how positional information is interpreted, is unclear. Here, the authors show that in mouse 3D embryonic stem cell cultures, there is self-patterning that depends on sequential
Externí odkaz:
https://doaj.org/article/1440dcdddfed461ca36cc2598fcdb630
Autor:
Nozomu Takata, Deepti Abbey, Luciano Fiore, Sandra Acosta, Ruopeng Feng, Hyea Jin Gil, Alfonso Lavado, Xin Geng, Ashley Interiano, Geoffrey Neale, Mototsugu Eiraku, Yoshiki Sasai, Guillermo Oliver
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1534-1549 (2017)
Summary: Recent advances in self-organizing, 3-dimensional tissue cultures of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provided an in vitro model that recapitulates many aspects of the in vivo developmental steps. Using
Externí odkaz:
https://doaj.org/article/2d5db34443344f38a2affff66a8f33a9
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 58-66 (2017)
Pluripotent stem cells can undergo repeated self-renewal while retaining genetic integrity, but they occasionally acquire aneuploidy during long-term culture, which is a practical obstacle for medical applications of human pluripotent stem cells. In
Externí odkaz:
https://doaj.org/article/ae2328b75b4f44b6aec025f4128b7050
Autor:
Yoshihito Ishida, Hideshi Kawakami, Hiroyuki Kitajima, Ayaka Nishiyama, Yoshiki Sasai, Haruhisa Inoue, Keiko Muguruma
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1482-1490 (2016)
Spinocerebellar ataxia type 6 (SCA6) is a dominantly inherited neurodegenerative disease characterized by loss of Purkinje cells in the cerebellum. SCA6 is caused by CAG trinucleotide repeat expansion in CACNA1A, which encodes Cav2.1, α1A subunit of
Externí odkaz:
https://doaj.org/article/2fde6dc2aea94fb6b00ac3eea83a2817
Autor:
Chikafumi Ozone, Hidetaka Suga, Mototsugu Eiraku, Taisuke Kadoshima, Shigenobu Yonemura, Nozomu Takata, Yutaka Oiso, Takashi Tsuji, Yoshiki Sasai
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
It is difficult to generate functional human anterior pituitary tissues in vitro. Here, Ozone et al. generate human anterior pituitary from embryonic stem cells by recapitulating in vivodevelopment, and demonstrate this tissue secretes hormones and r
Externí odkaz:
https://doaj.org/article/35be4cc4f7da4d0f83b9432016c75e6d
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 537-550 (2015)
During cerebellar development, the main portion of the cerebellar plate neuroepithelium gives birth to Purkinje cells and interneurons, whereas the rhombic lip, the germinal zone at its dorsal edge, generates granule cells and cerebellar nuclei neuro
Externí odkaz:
https://doaj.org/article/6d94a10d29af434a968ddd84845ea100
Autor:
Juthaporn Assawachananont, Michiko Mandai, Satoshi Okamoto, Chikako Yamada, Mototsugu Eiraku, Shigenobu Yonemura, Yoshiki Sasai, Masayo Takahashi
Publikováno v:
Stem Cell Reports, Vol 2, Iss 5, Pp 662-674 (2014)
In this article, we show that mouse embryonic stem cell- or induced pluripotent stem cell-derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner and outer segments even in an advanced retinal degeneration model
Externí odkaz:
https://doaj.org/article/8f1996afc76b41fcbbe1ea795f965f27
Autor:
Yoshihito Ishida, Hideshi Kawakami, Hiroyuki Kitajima, Ayaka Nishiyama, Yoshiki Sasai, Haruhisa Inoue, Keiko Muguruma
Publikováno v:
Cell Reports, Vol 18, Iss 4, Pp 1075-1076 (2017)
Externí odkaz:
https://doaj.org/article/e5d623c883214655b66287808954fe99
Autor:
Ryohei Numata, Naoki Okumura, Makiko Nakahara, Morio Ueno, Shigeru Kinoshita, Daisuke Kanematsu, Yonehiro Kanemura, Yoshiki Sasai, Noriko Koizumi
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88169 (2014)
The barrier and pump functions of the corneal endothelium are essential for the maintenance of corneal transparency. Although corneal transplantation is the only current therapy for treating corneal endothelial dysfunction, the potential of tissue-en
Externí odkaz:
https://doaj.org/article/4d090c9748184479a4754093701acb38
Autor:
Kazuya Ono, Tomoko Kita, Shigeru Sato, Paul O'Neill, Siu-Shan Mak, Marie Paschaki, Masataka Ito, Noriko Gotoh, Kiyoshi Kawakami, Yoshiki Sasai, Raj K Ladher
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004118 (2014)
Inner ear mechanosensory hair cells transduce sound and balance information. Auditory hair cells emerge from a Sox2-positive sensory patch in the inner ear epithelium, which is progressively restricted during development. This restriction depends on
Externí odkaz:
https://doaj.org/article/e01883298d9b4c3db82d0e438cc12a29