Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Yoshiki, Omatsu"'
Autor:
Taichi Nakatani, Tatsuki Sugiyama, Yoshiki Omatsu, Hitomi Watanabe, Gen Kondoh, Takashi Nagasawa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors. Here, we show that in mice whose CXC chemokine ligand 12 (CXCL12
Externí odkaz:
https://doaj.org/article/742939c84d284b499e2c2142078b2edf
Autor:
Yoshiki Omatsu
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-7 (2023)
Abstract Throughout adult life, most lineages of blood cells, including immune cells, are generated from hematopoietic stem cells (HSCs) in the bone marrow. HSCs are thought to require special microenvironments, termed niches, for their maintenance i
Externí odkaz:
https://doaj.org/article/f6341011a11d48108062333c244e6f43
Autor:
Yoshiki Omatsu, Shota Aiba, Tomonori Maeta, Kei Higaki, Kazunari Aoki, Hitomi Watanabe, Gen Kondoh, Riko Nishimura, Shu Takeda, Ung-il Chung, Takashi Nagasawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The transcription factors, Runx1 and Runx2 are critical embryonically for generation of HSCs and osteoblasts, respectively. Here the authors show that adult mice lacking Runx1 and Runx2 in HSC-supporting CAR cells displayed an increase in fibrosis wi
Externí odkaz:
https://doaj.org/article/a06851f3f0754d58b2f90fdc5a9f0c3d
Autor:
Toshinori Nakagawa, David J. Jörg, Hitomi Watanabe, Seiya Mizuno, Seungmin Han, Tatsuro Ikeda, Yoshiki Omatsu, Keiko Nishimura, Miyako Fujita, Satoru Takahashi, Gen Kondoh, Benjamin D. Simons, Shosei Yoshida, Takashi Nagasawa
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109875- (2021)
Summary: In mouse testis, a heterogeneous population of undifferentiated spermatogonia (Aundiff) harbors spermatogenic stem cell (SSC) potential. Although GFRα1+ Aundiff maintains the self-renewing pool in homeostasis, the functional basis of hetero
Externí odkaz:
https://doaj.org/article/65978c133f0e40fea4fb9cba4e4d510d
Publikováno v:
Current topics in microbiology and immunology. 434
Most types of blood cells, including immune cells are generated from hematopoietic stem cells (HSCs) within bone marrow in the adult. Most HSCs are in contact with and require the special microenvironment known as a niche for their maintenance. It ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0d410aef94fdc0312e67f23a39f5c13
https://pubmed.ncbi.nlm.nih.gov/34850281
https://pubmed.ncbi.nlm.nih.gov/34850281
Autor:
Yoshiki Omatsu, Shota Aiba, Tomonori Maeta, Kei Higaki, Kazunari Aoki, Hitomi Watanabe, Gen Kondoh, Riko Nishimura, Shu Takeda, Ung-il Chung, Takashi Nagasawa
Publikováno v:
Nature communications. 13(1)
In bone marrow, special microenvironments, known as niches, are essential for the maintenance of hematopoietic stem cells (HSCs). A population of mesenchymal stem cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells or leptin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33b9e2fe1741274faaad1b56ffe5092
https://pubmed.ncbi.nlm.nih.gov/35551452
https://pubmed.ncbi.nlm.nih.gov/35551452
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783030860158
Most types of blood cells, including immune cells are generated from hematopoietic stem cells (HSCs) within bone marrow in the adult. Most HSCs are in contact with and require the special microenvironment known as a niche for their maintenance. It ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::593749aca29f7808b779883421fb2a7e
https://doi.org/10.1007/978-3-030-86016-5_2
https://doi.org/10.1007/978-3-030-86016-5_2
Publikováno v:
International Immunology. 31:5-11
The special microenvironments, termed niches, with which hematopoietic stem cells (HSCs) are in contact, have been thought to be required for the maintenance of HSCs and the generation of immune cells in bone marrow. Although the identity of the HSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68739665b93a341e24e09ae6007dbc5
https://doi.org/10.1093/intimm/dxy058
https://doi.org/10.1093/intimm/dxy058
Publikováno v:
Genes & Development. 32:359-372
Bone marrow is the tissue filling the space between bone surfaces. Hematopoietic stem cells (HSCs) are maintained by special microenvironments known as niches within bone marrow cavities. Mesenchymal cells, termed CXC chemokine ligand 12 (CXCL12)-abu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22589075dccbe92a0a47f91e31b672da
https://doi.org/10.1101/gad.311068.117
https://doi.org/10.1101/gad.311068.117
Publikováno v:
Nature. 508:536-540
Haematopoietic stem and progenitor cells are maintained by special microenvironments known as niches in bone marrow. Many studies have identified diverse candidate cells that constitute niches for haematopoietic stem cells in the marrow, including os
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4484b76574a7103ee6c4eb9877635b11
https://doi.org/10.1038/nature13071
https://doi.org/10.1038/nature13071