Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Yoshikazu Sawada"'
Autor:
Yoshinori Takeuchi, Naoya Yahagi, Yuichi Aita, Yuki Murayama, Yoshikazu Sawada, Xiaoying Piao, Naoki Toya, Yukari Oya, Akito Shikama, Ayako Takarada, Yukari Masuda, Makiko Nishi, Midori Kubota, Yoshihiko Izumida, Takashi Yamamoto, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Osamu Urayama, Yasushi Kawakami, Yoko Iizuka, Takanari Gotoda, Keiji Itaka, Kazunori Kataoka, Ryozo Nagai, Takashi Kadowaki, Nobuhiro Yamada, Yuan Lu, Mukesh K. Jain, Hitoshi Shimano
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2373-2386 (2016)
Hepatic lipogenesis is nutritionally regulated (i.e., downregulated during fasting and upregulated during the postprandial state) as an adaptation to the nutritional environment. While alterations in the expression level of the transcription factor S
Externí odkaz:
https://doaj.org/article/c4e415d227f34f26b1b9099d2e05fb2b
Autor:
Hitoshi Shimano, Akito Shikama, Yoshikazu Sawada, Chen Ye, Yoshihiko Izumida, Kyoka Katabami, Yoshinori Takeuchi, Man Hei Ho, Samia Karkoutly, Takehito Sugasawa, Kazuhiro Takekoshi, Zahra Mehrazad Saber, Takafumi Miyamoto, Duhan Tao, Yuki Murayama, Naoya Yahagi, Yuichi Aita, Yukari Masuda, Takashi Matsuzaka, Yasushi Kawakami
Publikováno v:
Biochemical and Biophysical Research Communications. 582:35-42
High protein diet (HPD) is an affordable and positive approach in prevention and treatment of many diseases. It is believed that transcriptional regulation is responsible for adaptation after HPD feeding and Kruppel-like factor 15 (KLF15), a zinc fin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f4d73327f29884599bdf0ec4541eb0
https://doi.org/10.1016/j.bbrc.2021.10.027
https://doi.org/10.1016/j.bbrc.2021.10.027
Autor:
Takehito Okui, Masaya Iwashita, Maximillian A Rogers, Shiori Kuraoka, Arda Halu, Yoshikazu Sawada, Masanori Aikawa, Sasha A Singh, Elena Aikawa
Publikováno v:
Circulation. 144
Background: Cardiovascular calcification is a critical pathology associated with increased cardiovascular risk, but there are no FDA-approved anti-calcification therapies. Through an unbiased screening approach, we previously identified carnitine O-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d5a6b5b3d8dbc063d235ba525d8e376
https://doi.org/10.1161/circ.144.suppl_1.12316
https://doi.org/10.1161/circ.144.suppl_1.12316
Autor:
Yoko Sugano, Yuki Murayama, Takashi Matsuzaka, Hiroaki Yagyu, Motohiro Sekiya, Yasushi Kawakami, Yukari Masuda, Xianying Piao, Naoya Yahagi, Yuichi Aita, Hitoshi Iwasaki, Kazuto Kobayashi, Akito Shikama, Yoshinori Takeuchi, Yoshimi Nakagawa, Midori Kubota, Makiko Nishi-Tatsumi, Shigeru Yatoh, Hiroaki Suzuki, Hitoshi Shimano, Yoshihiko Izumida, Yoshikazu Sawada
Publikováno v:
FEBS Letters. 592:422-433
The SNP rs7903146 at the transcription factor 7-like 2 (TCF7L2) locus is established as the strongest known genetic marker for type 2 diabetes via genome-wide association studies. However, the functional SNPs regulating TCF7L2 expression remain uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986c35c75894f80ffda5711afaa13f7b
https://doi.org/10.1002/1873-3468.12975
https://doi.org/10.1002/1873-3468.12975
Autor:
Akito Shikama, Yoshimi Nakagawa, Yasushi Kawakami, Ryozo Nagai, Takashi Yamamoto, Yoshinori Takeuchi, Yuichi Aita, Naoki Toya, Yuan Lu, Makiko Nishi, Hitoshi Shimano, Yoko Iizuka, Naoya Yahagi, Yukari Masuda, Yoshikazu Sawada, Osamu Urayama, Xiaoying Piao, Yoshihiko Izumida, Takanari Gotoda, Nobuhiro Yamada, Takashi Kadowaki, Takashi Matsuzaka, Keiji Itaka, Kazunori Kataoka, Yuki Murayama, Motohiro Sekiya, Mukesh K. Jain, Ayako Takarada, Midori Kubota, Yukari Oya
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2373-2386 (2016)
SummaryHepatic lipogenesis is nutritionally regulated (i.e., downregulated during fasting and upregulated during the postprandial state) as an adaptation to the nutritional environment. While alterations in the expression level of the transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40465dd50339077ba7aa7de22f66317f
https://doi.org/10.1016/j.celrep.2016.07.069
https://doi.org/10.1016/j.celrep.2016.07.069
Autor:
Yukari Masuda, Motohiro Sekiya, Nobuhiro Wada, Yoshikazu Sawada, Akito Shikama, Hitoshi Iwasaki, Hiroaki Yagyu, Yuki Murayama, Hitoshi Shimano, EnXu Li, Yasushi Kawakami, Yuichi Aita, Zahra Mehrazad Saber, Yoshimi Nakagawa, Yoshihiko Izumida, Hiroaki Suzuki, Takashi Matsuzaka, Xianying Piao, Shigeru Yatoh, Naoya Yahagi, Midori Kubota, Yoko Sugano, Yoshinori Takeuchi, Makiko Nishi-Tatsumi, Takafumi Miyamoto, Kazuto Kobayashi
Publikováno v:
FEBS letters. 593(4)
Glucocorticoids have various medical uses but are accompanied by side effects. The glucocorticoid receptor (GR) has been reported to regulate the clock genes, but the underlying mechanisms are incompletely understood. In this study, we focused on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fbfc39f11cf9209e7291ed10652f34
https://pubmed.ncbi.nlm.nih.gov/30659595
https://pubmed.ncbi.nlm.nih.gov/30659595
Autor:
Ayumu Okuda, Tadaaki Ohgiya, Tomoaki Koshizawa, Tomoaki Fukuda, Nao Yamasaki, Kimiyuki Shibuya, Sumihiko Hagita, Yoshikazu Sawada, Morimoto Toshiharu, Gen Watanabe
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(19)
Herein, we describe the discovery, synthesis, and evaluation of a novel series of spiro[chromane-2,4′-piperidine] derivatives as G-protein-coupled receptor 119 agonists. Their initial design exploited the conformational restriction in the linker-to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0def888a6b8a4cd57be91a4bd899e2f
https://pubmed.ncbi.nlm.nih.gov/30145005
https://pubmed.ncbi.nlm.nih.gov/30145005
Autor:
Hitoshi Shimano, Yasushi Kawakami, Yoshihiko Izumida, Tomoki Murayama, Xiaoying Piao, Yoshikazu Sawada, Hiroaki Yagyu, Midori Kubota, Shigeru Yatoh, Yukari Masuda, Hiroaki Suzuki, Haruna Shinozaki, Makiko Nishi, Naoya Yahagi, Hitoshi Iwasaki, Ayako Takarada, Yuichi Aita, Kazuto Kobayashi, Yoshinori Takeuchi, Yukari Oya, Akito Shikama, Yoshimi Nakagawa, Takashi Matsuzaka, Naoki Toya, Nobuhiro Yamada
Publikováno v:
Biochemical and Biophysical Research Communications. 465:857-863
Fatty acid elongase 5 (ELOVL5) is an enzyme involved in the synthesis of polyunsaturated fatty acids. Sterol Regulatory Element-binding Protein (SREBP)-1 activates ELOVL5 and increases polyunsaturated fatty acid synthesis, which in turn negatively af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437837fb9264b2c016b9f7ce1509e60a
https://doi.org/10.1016/j.bbrc.2015.08.101
https://doi.org/10.1016/j.bbrc.2015.08.101
Autor:
Yuki Murayama, Akito Shikama, Xianying Piao, Naoya Yahagi, EnXu Li, Yoshikazu Sawada, Yoshimi Nakagawa, Nobuhiro Wada, Yoko Sugano, Shigeru Yatoh, Yasushi Kawakami, Yukari Masuda, Yuichi Aita, Kazuto Kobayashi, Yoshinori Takeuchi, Makiko Nishi-Tatsumi, Takashi Kadowaki, Hiroaki Yagyu, Midori Kubota, Motohiro Sekiya, Hitoshi Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Yoshihiko Izumida, Hiroaki Suzuki
Publikováno v:
Biochemical and biophysical research communications. 493(1)
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have both anti-diabetic and anti-obesity effects. However, the precise mechanism of the anti-obesity effect remains unclear. We previously demonstrated that the glycogen depletion signal triggers lipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077bae94523750523e08fa665acaba3c
https://pubmed.ncbi.nlm.nih.gov/28928093
https://pubmed.ncbi.nlm.nih.gov/28928093
Autor:
Akito Shikama, Hitoshi Shimano, Yoshimi Nakagawa, Yukari Masuda, Yoshihiko Izumida, Naoki Toya, Yoko Iizuka, Ayako Takarada, Yasushi Kawakami, Yoshinori Takeuchi, Xiaoying Piao, Makiko Nishi-Tatsumi, Naoya Yahagi, Yoshikazu Sawada, Yuki Murayama, Nobuhiro Yamada, Yuichi Aita, Takashi Kadowaki, Motohiro Sekiya, Takashi Matsuzaka, Yukari Oya, Midori Kubota
Publikováno v:
FEBS letters. 591(7)
Fatty acid synthase (Fasn) is a key component of energy metabolism that is dynamically induced by food intake. Although extensive studies have revealed a number of transcription factors involved in the fasting/refeeding transition of Fasn expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b7f99405f16eb03b0f8838ed0760ed
https://pubmed.ncbi.nlm.nih.gov/28281280
https://pubmed.ncbi.nlm.nih.gov/28281280