Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Yoshikazu Nishimura"'
Autor:
Tatsuya Tamura, Hiroshi Noda, Eri Joyashiki, Maiko Hoshino, Tomoyuki Watanabe, Masahiko Kinosaki, Yoshikazu Nishimura, Tohru Esaki, Kotaro Ogawa, Taiji Miyake, Shinichi Arai, Masaru Shimizu, Hidetomo Kitamura, Haruhiko Sato, Yoshiki Kawabe
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Hypoparathyroidism and osteoporosis can be treated with parathyroid hormone, but frequent injections are required. Here the authors develop a small-molecule agonist for the parathyroid hormone type I receptor that can be administered orally, and demo
Externí odkaz:
https://doaj.org/article/26ff462ed34f4f31ab3d012ea2e86ed2
Autor:
Yoshiaki Watanabe, Haruhiko Sato, Hidetomo Kitamura, Tomoya Kotake, Yoshikazu Nishimura, Masaru Shimizu, Takashi Emura, Kotaro Ogawa, Toru Esaki, Toshito Nakagawa, Akemi Mizutani, Yoshiyuki Furuta, Shinichi Arai, Hiroshi Noda, Masateru Ohta, Tatsuya Tamura, Yoshiaki Isshiki
Publikováno v:
Journal of Medicinal Chemistry. 63:5089-5099
We have previously shown that the oral administration of the small molecule hPTHR1 agonist PCO371 and its lead compound, 1 (CH5447240) results in PTH-like calcemic and hypophostemic activity in thyroparathyroidectomized rats. However, 1 was converted
Autor:
Masaru Shimizu, Yoshikazu Nishimura, Masateru Ohta, Toshito Nakagawa, Yoshiyuki Furuta, Naoki Okamoto, Yoshiaki Isshiki, Haruhiko Sato, Yoshiaki Watanabe, Hitoshi Saito, Hiroshi Noda, Tatsuya Tamura, Tomoya Kotake, Toru Esaki
Publikováno v:
Journal of Medicinal Chemistry. 61:5949-5962
During the course of derivatization of HTS hit 4a, we have identified a novel small-molecule hPTHR1 agonist, 1-(3,5-dimethyl-4-(2-((2-((1R,4R)-4-methylcyclohexyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-1-methylurea (CH544724
Autor:
Tohru Esaki, Eri Joyashiki, Kotaro Ogawa, Tomoyuki Watanabe, Taiji Miyake, Hidetomo Kitamura, Tatsuya Tamura, Shinichi Arai, Masaru Shimizu, Hoshino Maiko, Masahiko Kinosaki, Yoshikazu Nishimura, Yoshiki Kawabe, Haruhiko Sato, Hiroshi Noda
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications
Nature Communications
Parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor (PTHR1), a class B G-protein-coupled receptor. Hypoparathyroidism and osteoporosis can be treated with PTH injections; however, no or
Publikováno v:
Takaki, S, Nishimura, Y & Yamagishi, J 2019, Unsupervised Speaker Adaptation for DNN-based Speech Synthesis using Input Codes . in Asia-Pacific Signal and Information Processing Association Annual Summit and Conference 2018 . Institute of Electrical and Electronics Engineers (IEEE), Honolulu, Hawaii, USA, pp. 649-658, Asia-Pacific Signal and Information Processing Association Annual Summit and Conference 2018, Honolulu, United States, 12/11/18 . https://doi.org/10.23919/APSIPA.2018.8659621
APSIPA
APSIPA
A new speaker-adaptation technique for deep neural network (DNN)-based speech synthesis - which requires only speech data without orthographic transcriptions - is proposed. This technique is based on a DNN-based speech-synthesis model that takes spea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93687e5dfcb4588dbd36b03b6b0bcee6
https://www.pure.ed.ac.uk/ws/files/76318338/Unsupervised_speaker_adaptation_for_DNN_based_speech_synthesis_using_input_codes.pdf
https://www.pure.ed.ac.uk/ws/files/76318338/Unsupervised_speaker_adaptation_for_DNN_based_speech_synthesis_using_input_codes.pdf
Publikováno v:
Journal of Radiation Research
The influence of a host defense protein, lactoferrin (LF), contained in exocrine secretions such as milk, on radiation disorder was investigated. A total of 25 C3H/He mice in each of two groups were maintained with 0.1% LF-added and LF-free diets, re
Publikováno v:
Journal of the Japan Institute of Power Electronics. 38:65-69
Publikováno v:
RADIOISOTOPES. 60:443-459
In order to investigate the behavior and distribution of metallic elements including rare earth elements(REEs), thorium(Th) and uranium(U) in the agricultural field, these elements in agricultural soils were partitioned into 6 fractions by a sequenti
Autor:
Yoshikazu Nishimura, Tetsu Nishikawa, Takeshi Hiraoka, Nobuhiko Takai, Yasushi Ohmachi, Yuka Ishida, Yoshiya Shimada, Toshiaki Ogiu
Publikováno v:
Journal of Radiation Research. 52:257-263
Neutrons/Fetus/Neurobehavioral effects. Epidemiological studies have revealed that radiation causes brain development abnormalities in at omic bomb survivors exposed in utero. Rat and mouse studies have also shown that prenatal exposure to low-linear
Autor:
T. Ishikawa, Yoshikazu Nishimura, Hiroyuki Iso, Hitoshi Imaseki, Masae Yukawa, Shino Homma-Takeda
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 279(2):627-631
Microbeam analysis is used in biomedical and environmental sciences to determine the presence and concentration of trace elements. However, quantitative analyses of biological samples are challenging because the chemical and physical compositions of