Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Yoshikazu Iwasawa"'
Autor:
Fumihiko Takeuchi, Sotaro Ikeda, Yuta Tsukamoto, Yoshikazu Iwasawa, Chen Qihao, Yukie Otakaki, Ouda Ryota, Wan-Ling Yao, Ryo Narita, Hijikata Makoto, Koichi Watashi, Takaji Wakita, Koh Takeuchi, Kazuaki Chayama, Amane Kogure, Hiroki Kato, Takashi Fujita
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212233 (2019)
Currently, there is no available therapy to eradicate hepatitis B virus (HBV) in chronically infected individuals. This is due to the difficulty in eliminating viral covalently closed circular (ccc) DNA, which is central to the gene expression and re
Externí odkaz:
https://doaj.org/article/94d22ddf9e244e1fbd88ec3e073e6103
Autor:
Yoshikazu Iwasawa, Hidehito Kotani, Mitsuru Ohkubo, Nobuhiko Kawanishi, Satomi Miki, Ikuko Takahashi, Mayu Miyamoto, Tadahiro Nambu, Takumi Sakai, Tsutomu Kodera, Koji Ichikawa, Takashi Mita, Yoko Nakatsuru, Shinichi Hasako, Toshiyasu Shimomura
Supplementary Figure 1 from MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b079111e339740d4c7ac9bebcc68c05
https://doi.org/10.1158/1535-7163.22484802
https://doi.org/10.1158/1535-7163.22484802
Autor:
Yoshikazu Iwasawa, Hidehito Kotani, Mitsuru Ohkubo, Nobuhiko Kawanishi, Satomi Miki, Ikuko Takahashi, Mayu Miyamoto, Tadahiro Nambu, Takumi Sakai, Tsutomu Kodera, Koji Ichikawa, Takashi Mita, Yoko Nakatsuru, Shinichi Hasako, Toshiyasu Shimomura
Supplementary Figure 2 from MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b109bd2db35e12595e9b53c3a27e7b8
https://doi.org/10.1158/1535-7163.22484799
https://doi.org/10.1158/1535-7163.22484799
Autor:
Yoshikazu Iwasawa, Hidehito Kotani, Mitsuru Ohkubo, Nobuhiko Kawanishi, Satomi Miki, Ikuko Takahashi, Mayu Miyamoto, Tadahiro Nambu, Takumi Sakai, Tsutomu Kodera, Koji Ichikawa, Takashi Mita, Yoko Nakatsuru, Shinichi Hasako, Toshiyasu Shimomura
Aurora-A kinase is a one of the key regulators during mitosis progression. Aurora-A kinase is a potential target for anticancer therapies because overexpression of Aurora-A, which is frequently observed in some human cancers, results in aberrant mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e842eade4bbd48bf75c4ab6800c1f0
https://doi.org/10.1158/1535-7163.c.6531594.v1
https://doi.org/10.1158/1535-7163.c.6531594.v1
Autor:
Hidehito Kotani, Shinji Mizuarai, Takashi Yoshizumi, Takeshi Sagara, Toshihiro Sakamoto, Hiroharu Arakawa, Takumi Sakai, Jian Jiang, Tadahiro Nambu, Hiroko Oki, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Hiraku Itadani, Kazunori Yamanaka, Junko Ohtani, Naoki Kaneko, Toshifumi Kimura, Makiko Kobayashi, Toshihide Nishibata, Tsuyoshi Arai, Megumu Okada, Yoshikazu Iwasawa, Hiroshi Hirai
Supplementary Figure 4 from Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fbd4990659e663b7dccb7e40258433
https://doi.org/10.1158/1535-7163.22486068
https://doi.org/10.1158/1535-7163.22486068
Autor:
Hidehito Kotani, Shinji Mizuarai, Takashi Yoshizumi, Takeshi Sagara, Toshihiro Sakamoto, Hiroharu Arakawa, Takumi Sakai, Jian Jiang, Tadahiro Nambu, Hiroko Oki, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Hiraku Itadani, Kazunori Yamanaka, Junko Ohtani, Naoki Kaneko, Toshifumi Kimura, Makiko Kobayashi, Toshihide Nishibata, Tsuyoshi Arai, Megumu Okada, Yoshikazu Iwasawa, Hiroshi Hirai
Wee1 is a tyrosine kinase that phosphorylates and inactivates CDC2 and is involved in G2 checkpoint signaling. Because p53 is a key regulator in the G1 checkpoint, p53-deficient tumors rely only on the G2 checkpoint after DNA damage. Hence, such tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6083f36a3d2a471a2a2ebf46afa829f9
https://doi.org/10.1158/1535-7163.c.6532227.v1
https://doi.org/10.1158/1535-7163.c.6532227.v1
Autor:
Hidehito Kotani, Shinji Mizuarai, Takashi Yoshizumi, Takeshi Sagara, Toshihiro Sakamoto, Hiroharu Arakawa, Takumi Sakai, Jian Jiang, Tadahiro Nambu, Hiroko Oki, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Hiraku Itadani, Kazunori Yamanaka, Junko Ohtani, Naoki Kaneko, Toshifumi Kimura, Makiko Kobayashi, Toshihide Nishibata, Tsuyoshi Arai, Megumu Okada, Yoshikazu Iwasawa, Hiroshi Hirai
Supplementary Figure 3 from Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f3febe721d3504881be88ebdf1890e
https://doi.org/10.1158/1535-7163.22486071
https://doi.org/10.1158/1535-7163.22486071
Autor:
Yoshikazu Iwasawa, Hidehito Kotani, Mitsuru Ohkubo, Nobuhiko Kawanishi, Satomi Miki, Ikuko Takahashi, Mayu Miyamoto, Tadahiro Nambu, Takumi Sakai, Tsutomu Kodera, Koji Ichikawa, Takashi Mita, Yoko Nakatsuru, Shinichi Hasako, Toshiyasu Shimomura
Supplementary Table 1 from MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f10b3cadb9942618b8e754662d271c
https://doi.org/10.1158/1535-7163.22484796.v1
https://doi.org/10.1158/1535-7163.22484796.v1
Autor:
Hidehito Kotani, Shinji Mizuarai, Takashi Yoshizumi, Takeshi Sagara, Toshihiro Sakamoto, Hiroharu Arakawa, Takumi Sakai, Jian Jiang, Tadahiro Nambu, Hiroko Oki, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Hiraku Itadani, Kazunori Yamanaka, Junko Ohtani, Naoki Kaneko, Toshifumi Kimura, Makiko Kobayashi, Toshihide Nishibata, Tsuyoshi Arai, Megumu Okada, Yoshikazu Iwasawa, Hiroshi Hirai
Supplementary Figure 1 from Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fe199219c306c270d9d95973603ade
https://doi.org/10.1158/1535-7163.22486077
https://doi.org/10.1158/1535-7163.22486077
Autor:
Hidehito Kotani, Shinji Mizuarai, Takashi Yoshizumi, Takeshi Sagara, Toshihiro Sakamoto, Hiroharu Arakawa, Takumi Sakai, Jian Jiang, Tadahiro Nambu, Hiroko Oki, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Hiraku Itadani, Kazunori Yamanaka, Junko Ohtani, Naoki Kaneko, Toshifumi Kimura, Makiko Kobayashi, Toshihide Nishibata, Tsuyoshi Arai, Megumu Okada, Yoshikazu Iwasawa, Hiroshi Hirai
Supplementary Figure 2 from Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c548c563bdee1d537f11e9305fc523c6
https://doi.org/10.1158/1535-7163.22486074.v1
https://doi.org/10.1158/1535-7163.22486074.v1