Výsledky vyhledávání - "Yoshikazu Honda"

Akademický článek

BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant

Autor: Deepender Kaushik, Simran Dhingra, Madhuri T. Patil, Sakshi Piplani, Varun Khanna, Yoshikazu Honda-Okubo, Lei Li, Johnson Fung, Isaac G. Sakala, Deepak B. Salunke, Nikolai Petrovsky

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 16, Iss 8, Pp 1989-1996 (2020)

Better adjuvants are needed for vaccines against seasonal influenza. TLR7 agonists are potent activators of innate immune responses and thereby may be promising adjuvants. Among the imidazoquinoline compounds, 1-benzyl-2-butyl-1H-imidazo[4,5-c]quinol

Externí odkaz: https://doaj.org/article/2cd2603c6eb1498d8e7b8399fcbe1589

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Akademický článek

Development and Validation of a Novel Cuff-Less Blood Pressure Monitoring Device

Autor: Naoki Watanabe, MD, Yasuko K. Bando, MD, PhD, Taiji Kawachi, ME, Hiroshi Yamakita, ME, Kouki Futatsuyama, MSc, Yoshikazu Honda, ME, Hisae Yasui, RN, Kazuyuki Nishimura, MD, Takahiro Kamihara, MD, Takahiro Okumura, MD, PhD, Hideki Ishii, MD, PhD, Takahisa Kondo, MD, PhD, Toyoaki Murohara, MD, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 631-642 (2017)

Ordinary cuff-based blood pressure–monitoring devices remain a technical limitation that disturbs activities of daily life. Here we report a novel system for the cuff-less blood pressure estimation (CLB) that requires only 1 sensor for photoplethys

Externí odkaz: https://doaj.org/article/4cc19b734bf34d55a34235b5610147bf

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Akademický článek

An Advax-Adjuvanted Inactivated Cell-Culture Derived Japanese Encephalitis Vaccine Induces Broadly Neutralising Anti-Flavivirus Antibodies, Robust Cellular Immunity and Provides Single Dose Protection

Autor: Tomoyoshi Komiya, Yoshikazu Honda-Okubo, Jeremy Baldwin, Nikolai Petrovsky

Publikováno v: Vaccines, Vol 9, Iss 11, p 1235 (2021)

ccJE+Advax is an inactivated cell culture Japanese encephalitis (JE) vaccine formulated with Advax, a novel polysaccharide adjuvant based on delta inulin. This vaccine has previously shown promise in murine and equine studies and the current study so

Externí odkaz: https://doaj.org/article/3410be75772e476ab3979476c60a7d80

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Akademický článek

Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine

Autor: Yoshikazu Honda-Okubo, Harinda Rajapaksha, Dimitar Sajkov, David Gordon, Manon M. J. Cox, Nikolai Petrovsky

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 13, Iss 6, Pp 1261-1271 (2017)

Timely vaccine supply is critical during influenza pandemics but is impeded by current virus-based manufacturing methods. The 2009 H1N1/2009pdm ‘swine flu’ pandemic reinforced the need for innovation in pandemic vaccine design. We report on insig

Externí odkaz: https://doaj.org/article/e0ec924c229f448d81b12f17d2508944

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Akademický článek

Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines

Autor: Masayuki Hayashi, Taiki Aoshi, Yasunari Haseda, Kouji Kobiyama, Edward Wijaya, Noriyuki Nakatsu, Yoshinobu Igarashi, Daron M. Standley, Hiroshi Yamada, Yoshikazu Honda-Okubo, Hiromitsu Hara, Takashi Saito, Toshiyuki Takai, Cevayir Coban, Nikolai Petrovsky, Ken J. Ishii

Publikováno v: EBioMedicine, Vol 15, Iss C, Pp 127-136 (2017)

Advax, a delta inulin-derived microparticle, has been developed as an adjuvant for several vaccines. However, its immunological characteristics and potential mechanism of action are yet to be elucidated. Here, we show that Advax behaves as a type-2 a

Externí odkaz: https://doaj.org/article/259cd377fe0048e2bbbc73594e48f571

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Akademický článek

Advax-CpG Adjuvant Provides Antigen Dose-Sparing and Enhanced Immunogenicity for Inactivated Poliomyelitis Virus Vaccines

Autor: Yoshikazu Honda-Okubo, Jeremy Baldwin, Nikolai Petrovsky

Publikováno v: Pathogens, Vol 10, Iss 5, p 500 (2021)

Global immunization campaigns have resulted in a major decline in the global incidence of polio cases, with wild-type poliovirus remaining endemic in only two countries. Live oral polio vaccine (OPV) played a role in the reduction in polio case numbe

Externí odkaz: https://doaj.org/article/30453d2fe8eb4e329ed28b1e447b80c6

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Akademický článek

Delta Inulin Adjuvant Enhances Plasmablast Generation, Expression of Activation-Induced Cytidine Deaminase and B-Cell Affinity Maturation in Human Subjects Receiving Seasonal Influenza Vaccine.

Autor: Lei Li, Yoshikazu Honda-Okubo, Connie Li, Dimitar Sajkov, Nikolai Petrovsky

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132003 (2015)

There is a major need for new adjuvants to improve the efficacy of seasonal and pandemic influenza vaccines. Advax is a novel polysaccharide adjuvant based on delta inulin that has been shown to enhance the immunogenicity of influenza vaccine in anim

Externí odkaz: https://doaj.org/article/4aa58acd2eb6431695b3f864420ce174

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