Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Yoshikazu Fujimori"'
Autor:
Shinjiro Watanabe, Yoshikazu Fujimori, Akane Matsuzawa, Jun‐ichi Kobayashi, Hideaki Hirasawa, Yosuke Mutai, Fumiya Tanada
Publikováno v:
Neurourology and Urodynamics. 41:1336-1343
Transient receptor potential melastatin 8 (TRPM8) has a role in the abnormal sensory transduction of the bladder and is involved in the pathophysiology of hyperactivity bladder disorders. The aim of this study is to examine the effects of KPR-5714, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b1ddbb7ca61576d582b2cc47d80f3c
https://doi.org/10.1002/nau.24951
https://doi.org/10.1002/nau.24951
Autor:
Mutai Yosuke, Yoshikazu Fujimori, Fumiya Tanada, Yasuhiko Igawa, Hideaki Hirasawa, Osamu Nakanishi, Naoki Aizawa, Akane Matsuzawa, Takemitsu Hayashi, Jun-ichi Kobayashi
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:239-247
Transient receptor potential (TRP) melastatin 8 (TRPM8) is a temperature-sensing ion channel mainly expressed in primary sensory neurons (Aδ-fibers and C-fibers in the dorsal root ganglion). In this report, we characterized KPR-5714 (N-[(R)-3,3-difl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a6d27a3f0d6fec0674d438fdcf85f8
https://doi.org/10.1124/jpet.119.263616
https://doi.org/10.1124/jpet.119.263616
Autor:
Takeshi Nakabayashi, Noboru Kamada, Masayuki Isaji, Nobuhiko Fushimi, Masahiro Hiratochi, Hideki Fujikura, Kazuya Tatani, Isao Azumaya, Koichi Arakawa, Yoshikazu Fujimori, Kazuo Shimizu, Hidemasa Hikawa, Kenji Katsuno, Toshihiro Nishimura, Shinjiro Watanabe
Publikováno v:
Bioorganicmedicinal chemistry. 34
We optimized the structure of an active metabolite (1) of WAY-123783, which was obtained from mouse urine after oral administration, to improve selectivity for SGLT2 and oral bioavailability. O-glucoside derivative 24 (remogliflozin etabonate) was su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67d31b44d80c787e2a1cb681e75b10e
https://pubmed.ncbi.nlm.nih.gov/33581390
https://pubmed.ncbi.nlm.nih.gov/33581390
Autor:
Naoki, Aizawa, Yoshikazu, Fujimori, Osamu, Nakanishi, Takemitsu, Hayashi, Yoshiaki, Goi, Jun-Ichi, Kobayashi, Tomoe, Fujita
Publikováno v:
European journal of pharmacology. 899
Transient receptor potential melastatin 8 (TRPM8) channels may contribute to the pathophysiological bladder afferent hyperactivity, thus a TRPM8 antagonist would be a promising therapeutic target for the bladder hypersensitive disorders including uri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6de50f8ddc6afe9c8914c9ff4f0fc47
https://pubmed.ncbi.nlm.nih.gov/33675781
https://pubmed.ncbi.nlm.nih.gov/33675781
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 96:3-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6b318ab4f94322bb1c7964e1108db39
https://doi.org/10.1254/jpssuppl.96.0_3-b-p-188
https://doi.org/10.1254/jpssuppl.96.0_3-b-p-188
Autor:
Masahiko Yoshimoto, Takaaki Fuchikami, Motofumi Nakanishi, Hiroshi Kawaguchi, Hiromitsu Kimura, Shintaro Izumi, Mio Tsukahara, Yoshikazu Fujimori, Kyoji Marumoto
Publikováno v:
IEICE Transactions on Electronics. (4):233-242
This paper presents an algorithm for a physical activity (PA) classification and metabolic equivalents (METs) monitoring and its System-on-a-Chip (SoC) implementation to realize both power reduction and high estimation accuracy. Long-term PA monitori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a471cce0978f3d07933d4396ed76c366
https://hdl.handle.net/20.500.14094/90007078
https://hdl.handle.net/20.500.14094/90007078
Autor:
Isao Wanajo, Yoshikazu Fujimori, Takemitsu Hayashi, Hiroo Takeda, Morimichi Hayashi, Tomoya Onozato
Publikováno v:
NeuroReport. 28:779-787
Woozy (wz) mice develop ataxia and carry a mutation in the Sil1 gene. Homozygous wz mice have been characterized histopathologically, but no details of their motor function have been reported. In the present study, to comprehensively understand the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f1e891026c876b55f2690042ed3e9c
https://doi.org/10.1097/wnr.0000000000000816
https://doi.org/10.1097/wnr.0000000000000816
Autor:
Nobuhiko Fushimi, Toshihiro Inoue, Tetsuya Asari, Masaaki Takemura, Tomoya Onozato, Takao Kurooka, Yoshikazu Fujimori, Hiroo Takeda, Mamoru Kobayashi, Hironori Nishibe, Masayuki Isaji
Publikováno v:
European Journal of Pharmacology. 806:25-31
Chronic constipation is a highly common functional gastrointestinal disorder that adversely affects patient quality of life. At present, limited therapeutic options are available for the treatment of chronic constipation, which indicates the need for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baed403dbabe863a429f849d84e9e36
https://doi.org/10.1016/j.ejphar.2017.04.010
https://doi.org/10.1016/j.ejphar.2017.04.010
Autor:
Yoshikazu Fujimori, Noboru Kamada, Tomonaga Ozawa, Osamu Nakanishi, Tetsuya Ikeda, Tetsuji Ozawa, Hiroo Takeda, Jun-ichi Kobayashi, Hideaki Hirasawa
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:727-742
Transient receptor potential melastatin 8 (TRPM8) is activated by innocuous cold and chemical substances, and antagonists of this channel have been considered to be effective for pain and urinary diseases. N-(3-aminopropyl)-2-{[(3-methylphenyl)methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c065268d9434ea08f7266cd9844503
https://doi.org/10.1016/j.bmc.2016.11.049
https://doi.org/10.1016/j.bmc.2016.11.049
Autor:
Takemitsu Hayashi, Jun-ichi Kobayashi, Tomoe Fujita, Yoshiaki Goi, Naoki Aizawa, Osamu Nakanishi, Yoshikazu Fujimori
Publikováno v:
European Journal of Pharmacology. 899:173995
Transient receptor potential melastatin 8 (TRPM8) channels may contribute to the pathophysiological bladder afferent hyperactivity, thus a TRPM8 antagonist would be a promising therapeutic target for the bladder hypersensitive disorders including uri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f403103eea6f887414e11be3c97a279
https://doi.org/10.1016/j.ejphar.2021.173995
https://doi.org/10.1016/j.ejphar.2021.173995