Zobrazeno 1 - 10
of 491
pro vyhledávání: '"Yoshikatsu, Kanai"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract L-type amino acid transporter 1 (LAT1) is upregulated in various cancer types and contributes to disease progression. Previous studies have demonstrated or suggested that hypoxia-inducible factors (HIFs), the key transcription factors in hyp
Externí odkaz:
https://doaj.org/article/c30514178ca64db0a559525dab83eee2
Autor:
Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono, Takeru Ota, Eri Wakai, Takashi Sato, Yumi Ohta, Yoshiaki Kikkawa, Hidenori Inohara, Yoshikatsu Kanai, Hiroshi Hibino
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111214- (2024)
Summary: The cochlea contains two extracellular fluids, perilymph and endolymph. Endolymph exhibits high potential of approximately +80 to +110 mV (depending on species), which sensitizes sensory hair cells. Other properties of this unique fluid rema
Externí odkaz:
https://doaj.org/article/a5a5a7fba1804525bcf097dc9181cc42
Autor:
Ryo Taguchi, Kyoichi Kaira, Yu Miura, Tetsuya Umesaki, Atsuto Mouri, Hisao Imai, Hiroshi Kagamu, Masanori Yasuda, Yoshikatsu Kanai, Hiroyuki Nitanda, Hironori Ishida, Hirozo Sakaguchi
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37414- (2024)
Background: The L-type amino acid transporter (LAT1) exhibits significantly increased expression within tumor cells across various neoplasms. However, the clinical significance of LAT1 expression in patients with pleural mesothelioma (PM) remains unc
Externí odkaz:
https://doaj.org/article/31c2c6cffc66424fb45f3b27bb180f1b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract L-type amino acid transporter 1 (LAT1) is a transmembrane protein responsible for transporting large neutral amino acids. While numerous LAT1-targeted compound delivery for the brain and tumors have been investigated, their LAT1 selectivity
Externí odkaz:
https://doaj.org/article/d29a8f3a62244e529c9abef64be8af2a
Autor:
Weidong Zhang, Ayako Miura, Md Moin Abu Saleh, Koichiro Shimizu, Yuichiro Mita, Ryota Tanida, Satoshi Hirako, Seiji Shioda, Valery Gmyr, Julie Kerr-Conte, Francois Pattou, Chunhuan Jin, Yoshikatsu Kanai, Kazuki Sasaki, Naoto Minamino, Hideyuki Sakoda, Masamitsu Nakazato
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Insulin secretion from pancreatic β cells is regulated by multiple stimuli, including nutrients, hormones, neuronal inputs, and local signalling. Amino acids modulate insulin secretion via amino acid transporters expressed on β cells. The
Externí odkaz:
https://doaj.org/article/13b28fe0aa5b471fb9ba3b62af44728f
Autor:
Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Metastasis is the leading cause of mortality in cancer patients. L-type amino acid transporter 1 (LAT1, SLC7A5) is a Na+-independent neutral amino acid transporter highly expressed in various cancers to support their growth. Although high LA
Externí odkaz:
https://doaj.org/article/62d8a5ee21434925ba4bb14b499994a8
Autor:
Kou Nishikubo, Ryuichi Ohgaki, Xingming Liu, Hiroki Okanishi, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Cytotoxic anticancer drugs widely used in cancer chemotherapy have some limitations, such as the development of side effects and drug resistance. Furthermore, monotherapy is often less effective against heterogeneous cancer tissue
Externí odkaz:
https://doaj.org/article/e7e3be8231c3463188c9c0702abadfcd
Autor:
Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono, Satoru Kawamura, Eri Wakai, Tsuyoshi Miyoshi, Takashi Sato, Yumi Ohta, Takashi Saito, Takaomi C. Saido, Hidenori Inohara, Yoshikatsu Kanai, Hiroshi Hibino
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/cf37a8eb5b964041adb735ddaa9ddbf9
Autor:
Sangjon Pae, Shinichi Sakamoto, Xue Zhao, Shinpei Saito, Takaaki Tamura, Yusuke Imamura, Tomokazu Sazuka, Yoshie Reien, Yuri Hirayama, Hirofumi Hashimoto, Yoshikatsu Kanai, Tomohiko Ichikawa, Naohiko Anzai
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 4, Pp 251-258 (2022)
Amino acid transporters are responsible for the uptake of amino acids, critical for cell proliferation. L-type amino acid transporters play a major role in the uptake of essential amino acids. L-type amino acid transporter 1 (LAT1) exerts its functio
Externí odkaz:
https://doaj.org/article/022a458a306f4c69a54fb82a03f4a895
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Background Cancer-upregulated l-type amino acid transporter 1 (LAT1; SLC7A5) supplies essential amino acids to cancer cells. LAT1 substrates are not only needed for cancer rapid growth, but involved in cellular signaling. LAT1 has been propo
Externí odkaz:
https://doaj.org/article/1d18ba2038834ce497e31abb1bbd3315