Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Yoshiji Hantani"'
Autor:
Wataru Asano, Rie Hantani, Toru Uhara, François Debaene, Akihiro Nomura, Keishi Yamaguchi, Tsuyoshi Adachi, Kazuki Otake, Kazuhito Harada, Yoshiji Hantani
Publikováno v:
SLAS Discovery, Vol 29, Iss 2, Pp 100125- (2024)
Protein-protein interactions (PPIs) play a crucial role in most biological processes and are important targets in the development of therapeutic agents. However, small molecule drug discovery that targets PPIs remains very challenging. Targeting hot
Externí odkaz:
https://doaj.org/article/51ffe6d8f0bb4c71b052080e3f45db04
Publikováno v:
Chemical Thermodynamics and Thermal Analysis, Vol 8, Iss , Pp 100080- (2022)
Proteins fold into their most stable yet dynamic structures that enable their functions and exist in a balance between stability and instability. Protein folding and binding can be evaluated based on their thermodynamics determined using various meth
Externí odkaz:
https://doaj.org/article/cb3a19327e23462fa39122597ea957e3
Autor:
Kazuki Otake, Minoru Ubukata, Noboru Nagahashi, Naoki Ogawa, Yoshiji Hantani, Rie Hantani, Tsuyoshi Adachi, Akihiro Nomura, Keishi Yamaguchi, Mariko Maekawa, Hideaki Mamada, Takahisa Motomura, Motohide Sato, Kazuhito Harada
Publikováno v:
ACS Medicinal Chemistry Letters. 14:658-665
Autor:
Yoshiji Hantani, Kiyosei Iio, Rie Hantani, Kayo Umetani, Toshihiro Sato, Tracy Young, Katelyn Connell, Sam Kintz, Joshua Salafsky
Publikováno v:
FEBS Open Bio, Vol 8, Iss 9, Pp 1412-1423 (2018)
Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inh
Externí odkaz:
https://doaj.org/article/8d0437040b1b4dbdb797c18f711baa16
Autor:
Kyoko Fukushima, Rie Hantani, Shiori Naruoka, Yukiyo Toyonaga, Yuji Hori, Koichi Aoyagi, Hiroshi Yamanaka, Susumu Miyazaki, Atsuo Tanimoto, Seiji Kawashita, Yoshiji Hantani
Publikováno v:
Chemical Biology & Drug Design. 98:914-929
The development of small molecule inhibitors of programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) has drawn research interest for the treatment of cancer. Recently, we reported the discovery of a novel dimeric core small molecule PD
Autor:
Wataru Asano, Kenji Yamanaka, Yasunori Ohara, Toru Uhara, Satoki Doi, Takuya Orita, Tomoko Iwanaga, Tsuyoshi Adachi, Shingo Fujioka, Tatsuo Akaki, Kazutaka Ikegashira, Yoshiji Hantani
Publikováno v:
Biochemistry; 7/18/2023, Vol. 62 Issue 14, p2161-2169, 9p
Publikováno v:
Biochemistry. 59:1242-1251
Ganglioside GM3 is a sialylated membrane-based glycosphingolipid that regulates insulin receptor signaling via direct association with the receptor. The level of expression of GM3 synthase (GM3S) and GM3 is increased in tissues of patients with diabe
Autor:
Rie Hantani, Kyoko Fukushima, Koichi Aoyagi, Yukiyo Toyonaga, Hiroshi Yamanaka, Yuji Hori, Seiji Kawashita, Shiori Naruoka, Yoshiji Hantani, Susumu Miyazaki, Atsuo Tanimoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2464-2467
The development of small molecule inhibitors of PD-1/PD-L1 is eagerly anticipated for treatment of cancer. We focused on the symmetry of the ternary complex structure of reported small molecule ligands and hPD-L1 homodimers, and designed partially- o
Publikováno v:
SLAS Discovery. 24:457-465
Peripheral arterial disease (PAD) is an occlusive disease that can lead to atherosclerosis. The involvement of arginase II (Arg II) in PAD progression has been proposed. However, no promising drugs targeting Arg II have been developed to date for the
Autor:
Tracy A. Young, Toshihiro Sato, Sam Kintz, Kayo Umetani, Kiyosei Iio, Rie Hantani, Joshua Salafsky, Yoshiji Hantani, Katelyn Connell
Publikováno v:
FEBS Open Bio
Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inh