Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yoshihisa Shirasaki"'
Autor:
Laura Viviani, Kirsty Reid, Thierry Gastineau, Catherine Milne, Dean Smith, Robin Levis, Dianliang Lei, Mark van Ooij, Philippe Alexandre Gilbert, Joris Vandeputte, Jianxun Xie, Leena Madhuri, Shahjahan Shaid, Vaughn Kubiak, Rajinder Suri, Takuo Mizukami, Yoshihisa Shirasaki, Xiantang Li, Ying-Ying Zhou, Alla Trapkova, Sunil Goel, Jai Prakash, Amrullah Aninditio Subagio, Eniek Suwarni, Kyung Jin Jung, Gautam Sanyal, Pradip Das, Emmanuelle Coppens, David Wright, Zhechu Peng, Helle Northeved, Carmen Jungbäck, Tatiana Kirpitchenok, Lorenzo Del Pace, Borami Seo, Brinda Poojary, Antoniana Ottoni
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 78
This online workshop Accelerating Global Deletion of the Abnormal Toxicity Test for vaccines and biologicals. Planning common next steps was organized on October 14th, 2021, by the Animal Free Safety Assessment Collaboration (AFSA), the Humane Societ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5df4a6d56597992221dd09183c022a3
https://pubmed.ncbi.nlm.nih.gov/35840492
https://pubmed.ncbi.nlm.nih.gov/35840492
Autor:
Aiko Masuko, Yoshihisa Shirasaki, Kanako Iwakiri, Nagaaki Sato, Akiko Nozoe, Tsuyoshi Busujima, Kiyokazu Kitano, Eiji Munetomo, Hiroaki Tanaka, Fusayo Io, Masako Saito, Shunsuke Kamigaso, Kato Koji
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:228-238
We previously reported 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 2 as on orally available monoacylglycerol acyltransferase 2 (MGAT2) inhibitor which exhibited an in vivo efficacy at an oral dose o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76e1450019fccf9e436fe7d25935aaab
https://doi.org/10.1248/cpb.c15-00803
https://doi.org/10.1248/cpb.c15-00803
Autor:
Yoshihisa Shirasaki, Eiji Munetomo, Naoto Osaki, Kiyokazu Kitano, Hiroaki Tanaka, Nagaaki Sato, Toshiya Minagawa, Tsuyoshi Busujima, Masako Saito, Koji Yoshida
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5922-5931
MGAT2 (monoacylglycerol acyltransferase 2) is expected to be an attractive target for the drug treatment of obesity, diabetes, and other disease. We describe our exploration and structure-activity relationship (SAR) study of 2,3-dihydro-1H-isoindole-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1c84a9e33d5c1786857b189b8529cb
https://doi.org/10.1016/j.bmc.2015.06.065
https://doi.org/10.1016/j.bmc.2015.06.065
Autor:
Tsuyoshi, Busujima, Hiroaki, Tanaka, Kanako, Iwakiri, Yoshihisa, Shirasaki, Eiji, Munetomo, Masako, Saito, Aiko, Masuko, Kiyokazu, Kitano, Fusayo, Io, Koji, Kato, Shunsuke, Kamigaso, Akiko, Nozoe, Nagaaki, Sato
Publikováno v:
Chemicalpharmaceutical bulletin. 64(3)
We previously reported 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 2 as on orally available monoacylglycerol acyltransferase 2 (MGAT2) inhibitor which exhibited an in vivo efficacy at an oral dose o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4daba8aa320dfe9e522f08c800275b3
https://pubmed.ncbi.nlm.nih.gov/26936050
https://pubmed.ncbi.nlm.nih.gov/26936050
Autor:
Yoshihisa Shirasaki
Publikováno v:
Journal of Pharmaceutical Sciences. 97:2462-2496
Over the past two decades, many oral drugs have been designed in consideration of physicochemical properties to attain optimal pharmacokinetic properties. This strategy significantly reduced attrition in drug development owing to inadequate pharmacok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6cd6b075298c552b33b74985928e6a
https://doi.org/10.1002/jps.21200
https://doi.org/10.1002/jps.21200
Autor:
Yoshihisa Shirasaki, Osamu Sakai, Masayuki Nakamura, Jun Inoue, Masazumi Yamaguchi, Hiroyuki Miyashita
Publikováno v:
Journal of Medicinal Chemistry. 49:3926-3932
We previously reported a potent calpain inhibitor 1 (SJA6017, N-(4-fluorophenyl)-l-valyl-l-leucinal), which displayed relatively low oral bioavailability (BA). Replacing the metabolically labile aldehyde moiety of 1with more chemically stable warhead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a10c53b28aab852550850999f9369f
https://doi.org/10.1021/jm060157n
https://doi.org/10.1021/jm060157n
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:4473-4484
A novel series of dipeptidyl α-ketoamide derivatives with amphiphile was designed and synthesized as water-soluble calpain inhibitors. The introduction of amphiphiles at the P3 site increased water solubility without loss of membrane permeability an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabfe3cf88fcf173b6b77c6b29c10207
https://doi.org/10.1016/j.bmc.2005.04.059
https://doi.org/10.1016/j.bmc.2005.04.059
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 36:309-316
Validation of an analytical method for impurities and degradation products in an active pharmaceutical ingredient is important to assessment of quality and safety in a new pharmaceutical product. In the present study, a high-performance liquid chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5971b013a06ddfbac2dbe87ccc24ea
https://doi.org/10.1016/j.jpba.2004.06.006
https://doi.org/10.1016/j.jpba.2004.06.006
Autor:
Shin-ichi Ohyama, Taisuke Itaya, Yoshihisa Shirasaki, Yukiko Ono, Tae Kanai, Nobuhiro Muramoto
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:1464-1472
1-Benzyl-4, 6-dimethyl-4, 9-dihydro-1H-imidazo[1, 2-α]purin-9-one bearing an alkyl, a 1-alkenyl, a hydroxymethyl, a methoxymethyl, or a formyl group at the 7-position (3a-e) underwent rearrangement through fission and recyclization of the pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba9ec25d3ea488f9ccca823e02356e3f
https://doi.org/10.1248/cpb.47.1464
https://doi.org/10.1248/cpb.47.1464
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(19)
To investigate the molecular design of drugs that have good penetration into the retina from anterior segment of the eye via ocular instillation, we optimized the length of methoxyethylene glycol chain (mEG) in the P3 region of an oral bioavailable c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20db2e8aedcf21eca10a537efd661975
https://pubmed.ncbi.nlm.nih.gov/18789863
https://pubmed.ncbi.nlm.nih.gov/18789863