Výsledky vyhledávání - "Yoshihisa Nemoto"

Polymorphisms of Interleukin-1beta and beta3-Adrenergic Receptor in Japanese Patients With Nonalcoholic Steatohepatitis

Autor: Masafumi Ono, Makoto Hiroi, Toshiji Saibara, Shinji Iwasaki, Yoshihiro Hayashi, Hideaki Enzan, Saburo Onishi, Yasuko Nozaki, Naoaki Akisawa, Yoshihisa Nemoto

Publikováno v: Alcoholism: Clinical and Experimental Research. 28:106S-110S

Background: Obesity, hypertriglyceridemia, and diabetes have been reported as frequent complications observed in patients with nonalcoholic steatohepatitis (NASH) in Western countries. The aim of this study was to investigate the genetic predispositi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55970ee6ba7ef275b123c981db403cc9
https://doi.org/10.1111/j.1530-0277.2004.tb03226.x

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Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis

Autor: Yasuko Nozaki, John Raynor Vyselaar, Masafumi Ono, Zhang Shu-Ping, Makoto Hiroi, Toshiji Saibara, Saburo Onishi, Chikako Namikawa, Hideaki Enzan, Yoshihisa Nemoto, Naoaki Akisawa

Publikováno v: Journal of Hepatology. 40:781-786

Background/Aims The pathogenesis of non-alcoholic steatohepatitis (NASH) is poorly understood. The aim of this study was to examine genetic influences on NASH pathogenesis. Methods Blood samples from 63 patients with biopsy-proven NASH and 150 health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437bdb8018387b569e74dd9226b61d8a
https://doi.org/10.1016/j.jhep.2004.01.028

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Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar−/−) mice

Autor: Tetsu Egawa, Katsumi Toda, Yoshihisa Nemoto, Naoaki Akisawa, Saburo Onishi, Yoshihiro Hayashi, Masafumi Ono, Makoto Hiroi, Toshiji Saibara, Hideaki Enzan

Publikováno v: Lipids. 38:519-523

Tamoxifen is a potent antagonist of estrogen, and hepatic steatosis is a frequent complication in adjuvant tamoxifen for breast cancer. Impaired hepatic FA beta-oxidation in peroxisomes, microsomes, and mitochondria results in progression of massive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6b1d8c712b0db8a1f0e264aecd7ac8
https://doi.org/10.1007/s11745-003-1093-x

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A case of amebic liver abscess diagnosed by cytology

Autor: Miko Mitani, Tamotsu Takahashi, Miho Ichien, Shousuke Ueda, Toshiaki Moriki, Yoshihisa Nemoto, Hideo Kumazawa

Publikováno v: The Journal of the Japanese Society of Clinical Cytology. 42:45-48

背景:アメーバ性肝膿瘍は, 日常の細胞診で遭遇する機会はまれで, その報告は少ない. 今回, 細胞診が診断の根拠となった症例を経験したので報告する.症例:49歳, 男性. 高熱と腹痛を主訴�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1b616103830aecd9154ce3cd8e8891c
https://doi.org/10.5795/jjscc.42.45

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Altered expression of fatty acid–metabolizing enzymes in aromatase-deficient mice

Autor: Kiyomi Fujikawa-Adachi, Hideaki Enzan, Saburo Onishi, Masafumi Ono, Toshiji Saibara, Yoshihisa Nemoto, Teruhiko Okada, Yutaka Shizuta, Katsumi Toda

Publikováno v: Journal of Clinical Investigation. 105:1819-1825

Hepatic steatosis is a frequent complication in nonobese patients with breast cancer treated with tamoxifen, a potent antagonist of estrogen. In addition, hepatic steatosis became evident spontaneously in the aromatase-deficient (ArKO) mouse, which l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55be97e879faf1e846db03115e3a933
https://doi.org/10.1172/jci9575

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Genetic Background of Japanese Patients with Nonalcoholic Steatohepatitis (NASH)

Autor: Masafumi Ono, Naoaki Akisawa, Shinji Iwasaki, Yasuko Nozaki, Hideaki Enzan, Yoshihisa Nemoto, Zhang Shu-Ping, Ma Rui-Hong, Chikako Namikawa, Saburo Onishi, Toshiji Saibara, Makoto Hiroi

Publikováno v: NASH and Nutritional Therapy ISBN: 9784431213888

The pathogenesis of nonalcoholic steatohepatitis (NASH) is not understood well. Therefore, it is necessary to examine genetic influences on NASH pathogenesis. Two functional polymorphisms were studied: the −493 G/T polymorphism in the promoter of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::983c9a3d37af7318e22af4eddf3c9a62
https://doi.org/10.1007/4-431-27172-4_4

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A novel type hypertriglyceridemia observed in FLS mice

Autor: Yasuhiro Ogawa, Masaya Takahashi, Saburo Onishi, Shinji Iwasaki, Naoaki Akisawa, Shuichiro Inagaki, Katsumi Toda, Toshiji Saibara, Akihiko Wakatsuki, Masafumi Ono, Yoshihisa Nemoto

Publikováno v: Lipids. 38(7)

The unique inborn hypertriglyceridemia seen in FLS (fatty liver Shionogi) mice was relieved by the administration of purified apolipoprotein (apo) C-II. Lipoprotein lipase (LPL) and its cofactor, apoC-II, play a pivotal role in VLDL metabolism. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c529857e0826a77331d0e38aab117c28
https://pubmed.ncbi.nlm.nih.gov/14506831

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Tamoxifen-Induced Nonalcoholic Steatohepatitis

Autor: Hideaki Enzan, Katsumi Toda, Masafumi Ono, Toshiji Saibara, Akihiko Wakatsuki, Saburo Onishi, Yasuhiro Ogawa, Nan Xu, Yoshihisa Nemoto

Publikováno v: HCV/Oxidative Stress and Liver Disease ISBN: 9784431670070

Tamoxifen is a potent antagonist of estrogen and evidently improves the prognosis of patients with estrogen receptor-positive breast cancer. However, although tamoxifen has been shown to induce hepatic steatosis in one-third of nonobese breast cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caf473dea661a5ae30a719cdfa5e38b8
https://doi.org/10.1007/978-4-431-67005-6_11

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Tamoxifen-induced nonalcoholic steatohepatitis in breast cancer patients treated with adjuvant tamoxifen

Autor: Yoshihisa Nemoto, Toshiji Saibara, Masafumi Ono, Yasuhiro Ogawa, Saburo Onishi, Shinji Iwasaki, Naoaki Akisawa, Nan Xu, Takashi Maeda, Ting Zhang

Publikováno v: Internal medicine (Tokyo, Japan). 41(5)

Objective The benefits of 5-year tamoxifen administration for patients with estrogen receptor-positive breast cancer undoubtedly outweigh the risk of any adverse effects. Massive hepatic steatosis is an example of its side effects. Here we show risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0354a7caebe506f79ceb92c10bb37c66
https://pubmed.ncbi.nlm.nih.gov/12058881

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