Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Yoshihisa Kudo"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 2, Pp 93-109 (2023)
We have no definitive treatment for dementia characterized by prolonged neuronal death due to the enormous accumulation of foreign matter, such as β-amyloid. Since Alzheimer's type dementia develops slowly, we may be able to delay the onset and impr
Externí odkaz:
https://doaj.org/article/4430eea1a40e48e4b054a405d131e58c
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 1, Pp 38-42 (2015)
Evidence increasingly shows that astrocytes play a pivotal role in brain physiology and pathology via calcium dependent processes, thus the characterization of the calcium dynamics in astrocytes is of growing importance. We have previously reported t
Externí odkaz:
https://doaj.org/article/adea4f688e104e5d87f6b26a878149f7
Autor:
Tomoharu Yokoyama, Tadashi Tanoue, Erika Hasegawa, Yukio Ikeda, Shouichi Ohta, Akibumi Omi, Yoshihisa Kudo, Hiroyuki Uchino
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 3, Pp 228-240 (2012)
We examined the protective effects of the immunosuppressants cyclosporin A (CsA) and FK506 on abnormal cytosolic Ca2+ ([Ca2+]c) and mitochondrial Ca2+ concentration ([Ca2+]m) dynamics induced by ischemia or high l-glutamate concentration in mouse bra
Externí odkaz:
https://doaj.org/article/731e6ee0927c47f4bbe2e2f924a81bbc
Publikováno v:
Journal of Pharmacological Sciences, Vol 105, Iss 3, Pp 258-263 (2007)
Phosphoinositide-3 kinase (PI3K) and phospholipase C (PLC) utilize the same phosphoinositides as substrates to produce different signaling molecules. These enzymes are activated by a similar set of cell signaling mechanisms, i.e., tyrosine kinases an
Externí odkaz:
https://doaj.org/article/8032895531524a8b8ae2e077ebb14069
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137610 (2015)
Calcium releases of non-excitable cells are generally a combination of oscillatory and non-oscillatory patterns, and factors affecting the calcium dynamics are still to be determined. Here we report the influence of cell density on calcium increase p
Externí odkaz:
https://doaj.org/article/c047f7a33c4a413a92867252b2c16346
Publikováno v:
Journal of Pharmacological Sciences, Vol 100, Iss 2, Pp 126-132 (2006)
Abstract.: We investigated the effects of bifemelane, a nootropic drug, on the intracellular calcium concentration ([Ca2+]i) in rat cerebral astrocytes using a Ca2+ imaging device. At concentrations of 10 – 30 µM, bifemelane induced a slow onset a
Externí odkaz:
https://doaj.org/article/e7f87ad49a2442d1a6b08b9322d511a3
Effects of Bifemelane on the Calcium Level and ATP Release of the Human Origin Astrocyte Clonal Cell
Autor:
Yoshitoku Yoshida, Haruno Kumagai, Yoshiumi Ohkubo, Remi Tsuchiya, Mitsuhiro Morita, Hiroyoshi Miyakawa, Yoshihisa Kudo
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 1, Pp 121-128 (2006)
The effect of bifemelane hydrochloride (bifemelane) was examined on human origin astrocyte clonal cells (Kings-1). Bifemelane (125 – 1000 µM) induced a dose-dependent increase in the intracellular calcium concentration ([Ca2+]i). In the highest co
Externí odkaz:
https://doaj.org/article/9d18c84398854cacaeac42d77ca144f2
Autor:
Yoshitoku Yoshida, Remi Tsuchiya, Nagisa Matsumoto, Mitsuhiro Morita, Hiroyoshi Miyakawa, Yoshihisa Kudo
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 2, Pp 212-218 (2005)
We have investigated whether the intracellular calcium concentration ([Ca2+]i) oscillations induced in astrocytes using the metabotropic glutamate-receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) are Ca2+-dependent, using
Externí odkaz:
https://doaj.org/article/64ff933dcfc94375b214b00106d340a5
Publikováno v:
Journal of Pharmacological Sciences, Vol 94, Iss 1, Pp 25-30 (2004)
To study calcium imaging data of cell populations that have various response patterns in peak amplitude and frequency of calcium oscillation in response to stimulation, comprehensive characterization based on statistical analysis of each response is
Externí odkaz:
https://doaj.org/article/af441d0d739640d590146d7f0cf4b6d6
Publikováno v:
Journal of Pharmacological Sciences, Vol 95, Iss 3, Pp 341-348 (2004)
Although mannitol has been used as an osmotherapeutic drug on brain injury, the clinical efficiency of the drug are still controversial. In the present study, we examined the effects of mannitol on the edema in a hippocampal slice due to brief ischem
Externí odkaz:
https://doaj.org/article/049fc1e56d3445c0a752d2e5dc916ba3