Zobrazeno 1 - 10
of 576
pro vyhledávání: '"Yoshihisa, Kitamura"'
Autor:
Yasumasa Okawa, Soichiro Ushio, Yasuhisa Izushi, Yoshihisa Kitamura, Yoshito Zamami, Toshiaki Sendo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionIn this study, we aimed to examine the effects of chotosan, a traditional Japanese botanical drug, and its active component, Uncaria hook, on anxiety-like behaviors induced by systemic inflammation in mice.MethodsTo induce systemic inflam
Externí odkaz:
https://doaj.org/article/92a1f1ec307d45939a37ab0b687bf126
Autor:
Ayaka Fujimaki, Kazuki Ohuchi, Shinnosuke Takizawa, Takanori Murakami, Hisaka Kurita, Isao Hozumi, Xiaopeng Wen, Yoshihisa Kitamura, Zhiliang Wu, Yoichi Maekawa, Masatoshi Inden
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. The pathological hallmark of PD is the appearance of intraneuronal cytoplasmic α-synuclein (α-Syn) aggreg
Externí odkaz:
https://doaj.org/article/23e27bfe83714e1d87896050c05584de
Autor:
Hiromu Kawasaki, Hayato Hino, Fusako Takayama, Yoshihisa Kitamura, Toshiaki Sendou, Shingo Takatori
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 103-107 (2022)
We have reported that nicotine has a neurotrophic action on peripheral adrenergic nerves in vivo, which is mediated by α7 nicotinic acetylcholine receptors (nAChRs). To clarify the possible mechanisms, the present study further investigated the effe
Externí odkaz:
https://doaj.org/article/ee50beb85e3244da87bb80b1736f2747
Autor:
Soichiro Ushio, Yudai Wada, Mizuki Nakamura, Daiki Matsumoto, Kota Hoshika, Shoya Shiromizu, Naohiro Iwata, Satoru Esumi, Makoto Kajizono, Yoshihisa Kitamura, Toshiaki Sendo
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Hochuekkito (HET) is a Kampo medicine used to treat postoperative and post-illness general malaise and decreased motivation. HET is known to regulate immunity and modulate inflammation. However, the precise mechanism and effects of HET on inflammatio
Externí odkaz:
https://doaj.org/article/f9290a744937439abe699e3fcc31f169
Autor:
Masanori Hijioka, Kanori Kitamura, Daijiro Yanagisawa, Kaneyasu Nishimura, Kazuyuki Takata, Masatoshi Inden, Yoshihisa Kitamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 3, Pp 183-187 (2020)
Oxidative stress is associated with the progression of the neurodegenerative diseases Parkinson's disease (PD) and cerebral ischemia. Recently, 5-aminolevulinic acid (5-ALA), an intermediate in the porphyrin synthesis pathway, was reported to exert a
Externí odkaz:
https://doaj.org/article/6f342e388074485b8a5d8c48427bd00c
Autor:
Yasuyuki Masaoka, Yoichi Kawasaki, Ryo Kikuoka, Atsushi Ogawa, Satoru Esumi, Yudai Wada, Soichiro Ushio, Yoshihisa Kitamura, Toshiaki Sendo
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 6, Iss 1, Pp 1-7 (2020)
Abstract Background Valganciclovir (VGC) is essential for preventing cytomegalovirus infections after transplants in adult and pediatric patients. In pediatric patients, VGC tablets have to be pulverized so that they can be delivered via nasogastric
Externí odkaz:
https://doaj.org/article/e57ffe0fb0d244f688146fc6b391b3cc
Autor:
Kazuyuki Takata, Hiroyuki Kimura, Daijiro Yanagisawa, Koki Harada, Kaneyasu Nishimura, Yoshihisa Kitamura, Shun Shimohama, Ikuo Tooyama
Publikováno v:
Molecules, Vol 27, Iss 9, p 2780 (2022)
Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of Alzheimer’s disease (AD), but attenuation in choline signaling, including decreased nicotinic acetylcholine receptors (nAChRs), is evident in the early phase o
Externí odkaz:
https://doaj.org/article/ab2ff8dbd79c4906ad9553a201dbf8b7
Publikováno v:
Brain Sciences, Vol 12, Iss 2, p 162 (2022)
Intracerebral hemorrhage (ICH) is caused by the rupture of blood vessels in the brain. The excessive activation of glial cells and the infiltration of numerous inflammatory cells are observed during bleeding. Thrombin is a key molecule that triggers
Externí odkaz:
https://doaj.org/article/65ed777de50a48a6bb6edfd505e233c1
Autor:
Yuka Nakamura, Yoshihisa Kitamura, Yusuke Sumiyoshi, Nanami Naito, Shiho Kan, Soichiro Ushio, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 3, Pp 192-197 (2018)
We examined whether combination treatment with doxorubicin and cyclophosphamide, a traditional chemotherapy for breast cancer, induced anxiety-like behavior in rats. Furthermore, we evaluated the role of the serotonin (5-HT)2A receptor subtype in the
Externí odkaz:
https://doaj.org/article/a5c9dee91fcb4ef78f280ad772e9ee66
Autor:
Takahiro Hirayama, Nobuyuki Nosaka, Yasumasa Okawa, Soichiro Ushio, Yoshihisa Kitamura, Toshiaki Sendo, Toyomu Ugawa, Atsunori Nakao
Publikováno v:
Journal of Intensive Care, Vol 5, Iss 1, Pp 1-7 (2017)
Abstract Background In Japan, nafamostat mesylate (NM) is frequently used as an anticoagulant during continuous renal replacement therapy (CRRT). The dialyzer membrane AN69ST has been reported to adsorb NM and affect the management of anticoagulant t
Externí odkaz:
https://doaj.org/article/d11718808a9f47c39997dcdd2506780b