Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Yoshihiro Yamanaka"'
Autor:
Johji Nomura, Nathalie Busso, Annette Ives, Syunsuke Tsujimoto, Mizuho Tamura, Alexander So, Yoshihiro Yamanaka
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75527 (2013)
Excess reactive oxygen species (ROS) formation can trigger various pathological conditions such as inflammation, in which xanthine oxidase (XO) is one major enzymatic source of ROS. Although XO has been reported to play essential roles in inflammator
Externí odkaz:
https://doaj.org/article/69d601a545a8480791fa2a3016382f1c
Here we describe a step-by-step protocol for the derivation of axioloids, a pluripotent stem cell (PSC)-based 3D in vitro model of human segmentation and somitogenesis. Mesoderm-based axioloids capture reproducibly core features of the segmentation p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::927bef76268b5fd893fe5a4f4621148a
https://doi.org/10.21203/rs.3.pex-2114/v1
https://doi.org/10.21203/rs.3.pex-2114/v1
Autor:
Yoshihiro Yamanaka, Kumiko Yoshioka-Kobayashi, Sofiane Hamidi, Sirajam Munira, Kazunori Sunadome, Yi Zhang, Yuzuru Kurokawa, Ai Mieda, Jamie L. Thompson, Janet Kerwin, Steven Lisgo, Takuya Yamamoto, Naomi Moris, Alfonso Martinez-Arias, Taro Tsujimura, Cantas Alev
The segmented body plan of vertebrates is established during somitogenesis, a well-studied process in model organisms, but remains largely elusive in humans due to ethical and technical limitations. Despite recent advances with pluripotent stem cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0182152730d919cb08c0787152d23dd0
https://doi.org/10.1101/2022.06.03.494621
https://doi.org/10.1101/2022.06.03.494621
Autor:
Kenichi Fukiage, Makoto Watanabe, Shiro Ikegawa, Zheng Wang, Cantas Alev, Yoshihiro Yamanaka, Jing-Yi Xue, Megumi Nishio, Yann Pretemer, Junya Toguchida, Shunsuke Kawai, Tohru Futami, Masako Tsukanaka, Sanae Nagata, Sakura Tamaki
Publikováno v:
Stem Cell Reports
Summary Chondrodysplasias are hereditary diseases caused by mutations in the components of growth cartilage. Although the unfolded protein response (UPR) has been identified as a key disease mechanism in mouse models, no suitable in vitro system has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275bfd6280b1ee900d126311dd13e96e
https://doi.org/10.1016/j.stemcr.2021.01.014
https://doi.org/10.1016/j.stemcr.2021.01.014
Autor:
Ryoichiro Kageyama, Kumiko Yoshioka-Kobayashi, Mitsuhiro Matsuda, Makoto Ikeya, Hanako Hayashi, Yoshihiro Yamanaka, Cantas Alev, Junya Toguchida, Miki Ebisuya, Jordi Garcia-Ojalvo
Publikováno v:
Science. 369:1450-1455
Setting the tempo for development Many animals display similarities in their organization (body axis, organ systems, and so on). However, they can display vastly different life spans and thus must accommodate different developmental time scales. Two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838e8feec15bc2a4a3bc56324999c1e0
https://doi.org/10.1126/science.aba7668
https://doi.org/10.1126/science.aba7668
Our understanding of human somitogenesis is limited and largely based on insights gained from model organisms. Pluripotent stem cell-based in vitro approaches aiming to recapitulate distinct aspects of this core developmental process have recently be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fc47cc2167de86894fbdf6e07e9a050
https://doi.org/10.21203/rs.3.pex-827/v1
https://doi.org/10.21203/rs.3.pex-827/v1
Autor:
Masayuki Kitagawa, Toru Adachi, Junitsu Ito, Yoshihiro Yamanaka, Ikuro Ohta, Kazutoshi Fukase, Tadashi Katagiri
Publikováno v:
Internal Medicine
We herein report a case of hemichorea-hemiballism in an 85-year-old man diagnosed with diabetes at 76 years of age. After a one-year interruption in treatment, he was treated with a low-calorie diet, linagliptin, and nateglinide. Over 51 days, his Hb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a52611fab239dd01d44093457cdf05b
http://europepmc.org/articles/PMC5725863
http://europepmc.org/articles/PMC5725863
Autor:
Yoshihiro Yamanaka, Masayuki Kitagawa, Ikuro Ohta, Kazutoshi Fukase, Toru Adachi, Junitsu Ito, Tadashi Katagiri
Publikováno v:
Internal Medicine
Herein, we report on an 82-year-old woman who presented with anorexia. The patient had hyponatremia with preserved urinary osmotic pressure. T1-weighted magnetic resonance imaging (MRI) showed a lack of high signal intensity (SI) in the posterior pit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139dc01f7414be99db1b7561655bb102
https://doi.org/10.2169/internalmedicine.8616-16
https://doi.org/10.2169/internalmedicine.8616-16
Autor:
Makoto Ikeya, Ryoichiro Kageyama, Kumiko Yoshioka-Kobayashi, Jordi Garcia-Ojalvo, Yoshihiro Yamanaka, Hanako Hayashi, Cantas Alev, Miki Ebisuya, Junya Toguchida, Mitsuhiro Matsuda
While the mechanisms of embryonic development are similar between mouse and human, the tempo is in general slower in human. The cause of interspecies differences in developmental time remains a mystery partly due to lack of an appropriate model syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d434e1e94d591c42efdbbf28269ee443
Autor:
Takuya Yamamoto, Megumi Nishio, Hiroyuki Yoshitomi, Tomoko Matsumoto, Makoto Ikeya, Satoko Sakurai, Knut Woltjen, Yoshihiro Yamanaka, Long Guo, Ayako Nagahashi, Shunsuke Kihara, Megumu K. Saito, Shiro Ikegawa, Maya Uemura, Junya Toguchida, Miki Ebisuya, Mitsujiro Osawa, Masahiro Nakamura, Cantas Alev, Mitsuhiro Matsuda
Pluripotent stem cells (PSCs) have increasingly been used to model different aspects of embryogenesis and organ formation1. Despite recent advances in the in vitro induction of major mesodermal lineages and mesoderm-derived cell types2,3, experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300bdf448b3c7106bf6449520ce8ece2