Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Yoshihiro YOKOMIZO"'
Autor:
Kenji Yoshikawa, Toshiharu Yoshino, Makoto Takemura, Akiyoshi Mochizuki, Toshiharu Ohta, Tsutomu Nagata, Kouichi Uoto, Yoshihiro Yokomizo, Hiroyuki Naito, Katsuhiro Kawakami, Hideyuki Kanno, Makoto Suzuki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2133-2140
We previously reported on a series of cyclohexanediamine derivatives as highly potent factor Xa inhibitors. Herein, we describe the modification of the spacer moiety to discover an alternative scaffold. Ethylenediamine derivatives possessing a substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a646e3feedd1b429071692e1d9bc059
https://doi.org/10.1016/j.bmcl.2011.01.132
https://doi.org/10.1016/j.bmcl.2011.01.132
Autor:
Kenji Namba, Masami Ohtsuka, Yoshihiro Yokomizo, Hironobu Nitanai, Kazuki Hoshino, Makoto Takemura, Ving J. Lee, Kiyoshi Nakayama, Jason Z. Zhang, Yoshida Kenichi, William J. Watkins, Hiroko Kanda
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8506-8518
A series of 4-oxo-4H-pyrido[1,2-a]pyrimidine derivatives, derivatized at the 2-position with aromatic substituents, were synthesized by the Suzuki cross-coupling method and evaluated for their ability to potentiate the activity of the fluoroquinolone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facb25021fe9b43c48a8e2bae278cf1e
https://doi.org/10.1016/j.bmc.2006.08.037
https://doi.org/10.1016/j.bmc.2006.08.037
Autor:
Yoshida Kenichi, William J. Watkins, Monica Palme, Aesop Cho, Katsuya Akimoto, Kazuki Hoshino, Ving J. Lee, Atsunobu Sakamoto, Jason Z. Zhang, Haruko Kawato, Kiyoshi Nakayama, Hiroko Ishida, Masami Ohtsuka, Yoshihiro Yokomizo, Noriko Kuru, Toshiharu Ohta, Junko Itoh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2493-2497
Exchange of the ethylene tether in a series of pyridopyrimidine-based MexAB-OprM specific efflux pump inhibitors to an amide bond stabilized the olefin of the acrylic acid moiety, preventing facile photoisomerization to the Z-isomer. Furthermore, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9735d100912fc40fc6ce377c87008a
https://doi.org/10.1016/j.bmcl.2004.03.007
https://doi.org/10.1016/j.bmcl.2004.03.007
Autor:
Aesop Cho, Yoshida Kenichi, Monica Palme, William J. Watkins, Atsunobu Sakamoto, Toshiharu Ohta, Noriko Kuru, Ving J. Lee, Masami Ohtsuka, Jun Watanabe, Haruko Kawato, Jason Z. Zhang, Hiroko Ishida, Kiyoshi Nakayama, Kazuki Hoshino, Yoshihiro Yokomizo, Kumi Yoshida
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:475-479
The addition of substituents to the pyridopyrimidine scaffold of MexAB-OprM specific efflux pump inhibitors was explored. As predicted by a pharmacophore model, the incorporation substituents at the 2-position improved potency. Piperidines were found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc608919c67dc6a90ece8c90d78138ea
https://doi.org/10.1016/j.bmcl.2003.10.060
https://doi.org/10.1016/j.bmcl.2003.10.060
Autor:
Kumi Yoshida, Haruko Kawato, Yoshida Kenichi, William J. Watkins, Ving J. Lee, Yohei Ishida, Tsuyoshi Otani, Thomas E. Renau, Yoshihiro Yokomizo, Hiroko Ishida, Kazuki Hoshino, Masami Ohtsuka, Toshiharu Ohta, Yuichi Kurosaka, Kiyoshi Nakayama
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4205-4208
Problems of low solubility, high serum protein binding, and lack of efficacy in vivo in first generation MexAB-OprM specific efflux pump inhibitors were addressed. Through the use of pharmacophore modelling, the key structural elements for pump inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce3776787ba0face41d9b9b2e1c5165
https://doi.org/10.1016/j.bmcl.2003.07.027
https://doi.org/10.1016/j.bmcl.2003.07.027
Autor:
Yoshida Kenichi, Shigeru Hosono, William J. Watkins, Haruko Kawato, Yoshihiro Yokomizo, Kiyoshi Nakayama, Kumi Yoshida, Toshiharu Ohta, Kazuki Hoshino, Roger Leger, Masami Ohtsuka, Ving J. Lee, Jason Z. Zhang, Yohei Ishida, Thomas E. Renau, Hiroko Ishida
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4201-4204
The identification of a series of compounds that specifically inhibit efflux by the MexAB-OprM pump system in Pseudomonas aeruginosa is described. Synthesis and in vitro structure-activity relationships (SARs) are outlined. Early leads lacked activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d452727d2a774f33b9b5ed19e7e931ef
https://doi.org/10.1016/j.bmcl.2003.07.024
https://doi.org/10.1016/j.bmcl.2003.07.024
Autor:
Yasuyuki TAKEDA, Keiichi KAWAGOE, Aki YOKOMIZO, Yoshihiro YOKOMIZO, Toru HOSOKAMI, Yoshimasa SHIMOTO, Yoshiaki TABUCHI, Yoshiyasu OGIHARA, Yuko HONDA, Keiko KAWARABAYASHI, Miki ISERI, Shuichi YOKOHAMA
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:755-771
In order to improve the biological characteristics of DA-3934 (5), a novel gastrin/cholecystokinin (CCK)-B receptor antagonist, phenoxyacetic acid derivatives replacing the N-methyl-N-phenylcarbamoylmethyl moiety of 5 with various alkyl chains have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f40ab67adeb5103712825d89a2a0cd8
https://doi.org/10.1248/cpb.47.755
https://doi.org/10.1248/cpb.47.755
Publikováno v:
ChemInform. 24
In the presence of catalytic amounts of [1,2-benzenediolato(2-)-O,O′]oxotitanium and trimethylsilyl triflate, 1-O-trimethylsilyl-2,3,5-tri-O-benzyl-D-arabinofuranose stereoselectively reacts with various trimethylsilyl ethers to afford the correspo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1d44b5024ab450c55fc26160e991b74
https://doi.org/10.1002/chin.199313270
https://doi.org/10.1002/chin.199313270
Publikováno v:
Chemistry Letters. 21:1401-1404
In the presence of catalytic amounts of [1,2-benzenediolato(2-)-O,O′]oxotitanium and trimethylsilyl triflate, 1-O-trimethylsilyl-2,3,5-tri-O-benzyl-D-arabinofuranose stereoselectively reacts with various trimethylsilyl ethers to afford the correspo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b426d254d974f11cf024d905c00f824c
https://doi.org/10.1246/cl.1992.1401
https://doi.org/10.1246/cl.1992.1401
Autor:
Kazuki Hoshino, Yoshida Kenichi, William J. Watkins, Atsunobu Sakamoto, Masami Ohtsuka, Kumi Yoshida, Yoshihiro Yokomizo, Yuichiro Imamura, Kiyoshi Nakayama, Hironobu Nitanai, Hiroko Kanda, Makoto Takemura, Ving J. Lee, Jason Z. Zhang, Noriko Kuru, Kenji Namba
Publikováno v:
Bioorganicmedicinal chemistry. 15(22)
A series of 4-oxo-4 H -pyrido[1,2- a ]pyrimidine derivatives, substituted at the 2-position with piperidines bearing quaternary ammonium salt side chains, were synthesized and evaluated for their ability to potentiate the activity of the fluoroquinol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be657d6aa5504b86ff1ce674c0790dbe
https://pubmed.ncbi.nlm.nih.gov/17869116
https://pubmed.ncbi.nlm.nih.gov/17869116