Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Yoshihiro Usui"'
Autor:
Adachi Takashi, Narihiko Yoshii, Kazutoshi Watanabe, Fumiaki Uehara, Mika Nabeno, Takashi Horikawa, Kenji Fukunaga, Ken-Ichi Saito, Shinji Sunada, Satoshi Yokoshima, Shinji Tanaka, Satoshi Yuki, Shouichi Asano, Aya Shouda, Hiroshi Tanaka, Shinsuke Hiki, Keiichi Aritomo, Masatake Fujimura, Keiji Yamagami, Yoshihiro Usui, Jun-ichi Eguchi
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(16)
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15af65e99a9d19a8f0c2d46937023c5e
https://pubmed.ncbi.nlm.nih.gov/28712708
https://pubmed.ncbi.nlm.nih.gov/28712708
Autor:
Jun-ichi Eguchi, Shinsuke Hiki, Masatake Fujimura, Satoshi Yuki, Shinji Sunada, Tokushi Hanano, Masahiro Okuyama, Fumiaki Uehara, Toshiyuki Kohara, Hiroshi Tanaka, Keiichi Aritomo, Susumu Tsuchiya, Ken-Ichi Saito, Kenji Fukunaga, Kazutoshi Watanabe, Shoichi Asano, Koichi Yamakoshi, Hiroshi Baba, Shinji Tanaka, Takashi Horikawa, Yoshihiro Usui, Aya Shoda, Akiko Mori, Keiji Yamagami
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6933-6937
A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found 21, 29 and 30 to possess potent in vitro GSK-3β inhibitory activity with g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a885218d2050bd32f637b9c4aaa1822
https://doi.org/10.1016/j.bmcl.2013.09.020
https://doi.org/10.1016/j.bmcl.2013.09.020
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5749-5751
An asymmetric synthesis of 2-arylpiperazines starting from phenacyl bromides, a variety of which are easily available, has been established. The synthesis features a CBS reduction of phenacyl bromide to provide optically enriched compounds, an SN2 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f39886bd51a3535ab4f28ad95ee84c
https://doi.org/10.1016/j.bmcl.2014.10.047
https://doi.org/10.1016/j.bmcl.2014.10.047
Autor:
Hiroaki Ueno, Robert Apaya, Tomonori Arai, Robert George Boyle, Etsuko Wada, Toshiro Sakaki, Yoshihiro Usui, Tim Mitchell, Hiroaki Iijima, Keiji Wada, Graham Andrew Showell, Hiroshi Shimada, John Humphries
Publikováno v:
Journal of Peptide Science. 11:136-141
Extensive SAR studies on the unselective BRS3 agonist, [H-D-Phe6,β-Ala11,Phe13,Nle14]-bombesin-(6-14)-nonapeptide amide, have highlighted structural features important for BRS3 activity and have provided guidance as to the design of selective agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff23dd36cf0612f03ed4ec108a106b0e
https://doi.org/10.1002/psc.599
https://doi.org/10.1002/psc.599
Publikováno v:
Orthopedics & Traumatology. 41:702-705
Ulcers often develop on the lateral malleolar area in aged patients and are difficult to heal.We describe a simple surgical method to treat the ulcer. This procedure is as follows:1. Resection of long and short fibular tendons.2. The cortical bone of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ef2bc5792e1fa187bf7845f0620c7a8
https://doi.org/10.5035/nishiseisai.41.702
https://doi.org/10.5035/nishiseisai.41.702
Publikováno v:
Journal of the Less Common Metals. 175:171-176
Use of the dissolution of magnesium metal in liquid ammonia enabled novel magnesium-containing hydrogen storage materials to be prepared. The dispersion of magnesium atoms in ammonia matrices at 77 K using a metal vapour technique gave rise to a homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ab6d8e911ac859da182488498760f37
https://doi.org/10.1016/0022-5088(91)90362-8
https://doi.org/10.1016/0022-5088(91)90362-8
Publikováno v:
Orthopedics & Traumatology. 39:1677-1683
A method was applied for conservative treatment of 48 toes in the 180 toes 130 cases that a part of the nail wall and all granulation tissue were excised to disclose edges of the nail plate. The method was used when a dressing was changed at out-pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9999b4e20e74d4edc45caf44bcfc9ae8
https://doi.org/10.5035/nishiseisai.39.1677
https://doi.org/10.5035/nishiseisai.39.1677
Autor:
Yoshihiro Usui
Publikováno v:
Orthopedics & Traumatology. 38:1410-1413
An operative method to create interdigital space was described. In this method, a pantaloon flap on the dorsal side and a triangular flap on the palmar or plantar side are designed, and two flaps are inserted to interdigital space from each side. Ski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c7fbebcaa0a3eb9ef2736dfb74edf62
https://doi.org/10.5035/nishiseisai.38.1410
https://doi.org/10.5035/nishiseisai.38.1410
Publikováno v:
Orthopedics & Traumatology. 39:276-280
We studied long-turm results of treatment of ischial decubitus ulcers and had the conclusion as follows. Many cases of ischial decubitus ulcers had recurrence and a prevention of the recurrence was difficult, even if a good cushion was constructed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d00e5b0f04ffd1f6d3b24edf7403d07b
https://doi.org/10.5035/nishiseisai.39.276
https://doi.org/10.5035/nishiseisai.39.276
Publikováno v:
Peptides. 24(1)
Mice lacking a functional bombesin receptor subtype-3 (BRS-3) develop mild obesity. However, the origin of obesity in BRS-3 knockout (KO) mice remains unclear. We used a strain-crossing strategy to investigate the physiological role of the BRS-3 path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9b963b67a2f466a21832afbb12ff9e
https://pubmed.ncbi.nlm.nih.gov/12576088
https://pubmed.ncbi.nlm.nih.gov/12576088