Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yoshihiro Maeshiba"'
Publikováno v:
Arzneimittelforschung. 52:664-668
The pharmacokinetic interaction between TAK-044 (cyclo[D-alpha-aspartyl-3-[(4-phenylpiperazin-1-yl)carbonyl]-L-alanyl-L- alpha-aspartyl-D-2-(2-thienyl) glycyl-L-leucyl-D-tryptophyl] disodium, CAS 157380-72-8) and ciclosporin (CAS 59865-13-3) was inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1caaa18c913a1c0b2065a80d1cfacf
https://doi.org/10.1055/s-0031-1299948
https://doi.org/10.1055/s-0031-1299948
Autor:
Tomoaki Higuchi, Takuya Ebihara, Toshiyuki Takeuchi, Masahiro Kawase, Masami Nonaka, Sumie Yoshitomi, Satoru Asahi, Yoshihiro Maeshiba
Publikováno v:
Biopharmaceutics & Drug Disposition. 29:311-323
The role of P-glycoprotein (P-gp, ABCB1) on the absorption process was investigated by drug–drug interaction studies of TAK-427 with P-gp inhibitors (erythromycin, ketoconazole or quinidine) in rats and by transport studies using rat multidrug resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9427920be3ad3ab83d2814f5431d2223
https://doi.org/10.1002/bdd.609
https://doi.org/10.1002/bdd.609
Autor:
Setsuo Harada, Yoshihiro Maeshiba, Nobuhiro Inatomi, Zen Itoh, Shigeharu Tanayama, Yasunori Funabashi, Satoshi Omura
Publikováno v:
The Journal of Antibiotics. 49:794-801
Two motilides, EM574 (N-demethyl-N-isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal) and EM523 (N-demethyl-N-ethyl-8,9-anhydroerythromycin A 6,9-hemiacetal) have strong gastrointestinal motor stimulating (GMS) activity. When administered orally to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b0e2c7d2e6dd519d77f7d5453065b4
https://doi.org/10.7164/antibiotics.49.794
https://doi.org/10.7164/antibiotics.49.794
Autor:
Yoshihiko Tagawa, Mitsuhiro Nishihara, Hidenori Kamiguchi, Naohiro Kawaguchi, Yoshihiro Maeshiba, Miyako Sudo, Yutaka Kiyota, Junzo Takahashi, Takahiro Kondo, Satoru Asahi
Publikováno v:
Drug metabolism and pharmacokinetics. 27(2)
Summary: Sipoglitazar is a novel anti-diabetic agent with triple agonistic activities on the human peroxisome proliferator-activated receptors, hPPAR-γ, -α, and -δ. The bioavailability for sipoglitazar was 95.0% and 72.6% in rats and monkeys respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56745d037935e6b80d080e10067c185b
https://pubmed.ncbi.nlm.nih.gov/22123126
https://pubmed.ncbi.nlm.nih.gov/22123126
Autor:
Setsuo Harada, Zen Itoh, Nobuhiro Inatomi, Yoshihiro Maeshiba, Yasunori Funabashi, Satoshi Omura, Shigeharu Tanayama
Publikováno v:
ChemInform. 28
Two motilides, EM574 (N-demethyl-N-isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal) and EM523 (N-demethyl-N-ethyl-8,9-anhydroerythromycin A 6,9-hemiacetal) have strong gastrointestinal motor stimulating (GMS) activity. When administered orally to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c24c00becfb5218a939471e88667be1
https://doi.org/10.1002/chin.199706232
https://doi.org/10.1002/chin.199706232
Autor:
Takahiro Kondo, Toshiyuki Takeuchi, Ryoichi Tsukuda, Yoshihiro Maeshiba, Kenji Yamashita, Yoshinobu Yoshimura
Publikováno v:
Arzneimittel-Forschung. 52(8)
The disposition of TAK-044 (cyclo[D-alpha-aspartyl-3-[(4-phenylpiperazin-1-yl)carbonyl]-L-alanyl-L- alpha-aspartyl-D-2-(2-thienyl) glycyl-L-leucyl-D-tryptophyl] disodium, CAS 157380-72-8), a new endothelin antagonist, was studied in rats and dogs by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4021d87a8d8d4e9603f76671d286c546
https://pubmed.ncbi.nlm.nih.gov/12236045
https://pubmed.ncbi.nlm.nih.gov/12236045
Autor:
Kenji Yamashita, Toshiyuki Takeuchi, Yoshihiko Tagawa, Kiyoshi Hagihara, Ryoichi Tsukuda, Yoshihiro Maeshiba, Yoshinobu Yoshimura
Publikováno v:
Biopharmaceuticsdrug disposition. 22(6)
The mechanism of the nonlinear pharmacokinetics of TAK-044 in rats was shown from in vivo and in vitro studies to be due to capacity-limited hepatic uptake. In the rats, which were given intravenous injections of 14C-labeled TAK-044 ([14C]TAK-044) (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4056af33a14231c7f059fb6c59e792a
https://pubmed.ncbi.nlm.nih.gov/11754038
https://pubmed.ncbi.nlm.nih.gov/11754038
Autor:
Yoshihiro Maeshiba
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::568754e53fe1c48f2350247a3a976cad
https://doi.org/10.2133/dmpk.13.45
https://doi.org/10.2133/dmpk.13.45
Autor:
Asao Tanioka, Takeshi Iwamoto, Hiromasa Araki, Yoshihiro Maeshiba, Hideki Moritoki, Yukio Ishida
Publikováno v:
British Journal of Pharmacology. 95:1015-1022
1. The effects of aging on histamine-induced vasodilatation and cyclic GMP production in rat thoracic aorta were investigated. 2. This histamine-induced dilatation of the aorta was mediated by H1-receptors and was dependent on the endothelium. 3. His
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663fe7243efe11db03df250b44d74660
https://doi.org/10.1111/j.1476-5381.1988.tb11734.x
https://doi.org/10.1111/j.1476-5381.1988.tb11734.x
Autor:
Yukio Ishida, Hideki Moritoki, Hiroshi Fukuda, Takeshi Iwamoto, Jun Kenaya, Yoshihiro Maeshiba
Publikováno v:
European journal of pharmacology. 140(1)
Verapamil (3 X 10(-6)-3 X 10(-5) M) enhanced the twitch contractions of the epididymal and prostatic portions of vas deferens stimulated at 0.1 Hz. This verapamil effect was essentially similar to those of diltiazem, D-600 and Bay K 8644. However, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f00bfd0cf83721cba136aa2c5fbd5c
https://pubmed.ncbi.nlm.nih.gov/3113986
https://pubmed.ncbi.nlm.nih.gov/3113986