Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yoshihiro Kiyota"'
Autor:
Yoshihiro Kiyota, Craig A. Behnke, Takahiro Matsumoto, Junichi Miyazaki, Shigeru Igaki, Toru Kawamura, Mitsunori Kono, Masakuni Kori, Hideyuki Oki, Atsushi Nishimura, Masato Shimojo
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:28-41
A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH) inhibitors that are therapeutically effective against pain. We carried out an optimization study of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fe0e6423f9c80cdc30c75070da14d9
https://doi.org/10.1016/j.bmc.2012.11.006
https://doi.org/10.1016/j.bmc.2012.11.006
Publikováno v:
Neuroscience Research. 57:424-433
Hypothermia is the only neuroprotective therapy proven to be clinically effective. Identifying the molecules that play important roles in the efficacy of hypothermia, we developed a multi-channel computer-controlled system, in which the brain tempera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481e0eca3bc1bea58d63f51bd976847a
https://doi.org/10.1016/j.neures.2006.12.002
https://doi.org/10.1016/j.neures.2006.12.002
Autor:
Kerstin Pahlmark, Yoshihiro Kiyota, Maj-Lis Smith, Hajime Memezawa, Jaroslava Folbergrová, Bo K. Siesjö
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 13:145-152
Recent results suggest that even relatively brief periods of ischemia in gerbils (10 min) lead to oxidative damage to brain proteins, reflected in an increased carbonyl content in the soluble protein fraction and a decreased glutamine synthetase (GS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a123a31557ebc22b4362620fc47548
https://doi.org/10.1038/jcbfm.1993.17
https://doi.org/10.1038/jcbfm.1993.17
Autor:
Masato Shimojo, Satoru Asahi, Hiroyuki Ohta, Kazuko Hirai, Yasuko Terao, Yasufumi Sakura, Yoshihiro Kiyota, Hidenori Kamiguchi, Yasushi Shintani, Saku Miyamoto
Publikováno v:
Neuroreport. 20(8)
Although moderate hypothermia is one of the most robust and effective techniques available for reducing ischemic injury, its key mechanism still remains unclear. Our proteomic analysis of the brains of rats treated with a 2-h middle cerebral artery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9869abec877d360b88d3ac2b8a91ff4e
https://pubmed.ncbi.nlm.nih.gov/19352207
https://pubmed.ncbi.nlm.nih.gov/19352207
Autor:
Yoshihiro Kiyota, Tomoyoshi Nishizaki
Publikováno v:
Kobunshi. 40:376-379
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ac38237f3def3d5236dcd444d418554
https://doi.org/10.1295/kobunshi.40.376
https://doi.org/10.1295/kobunshi.40.376
Publikováno v:
Brain Research. 538:295-302
The relationship between changes in learning behavior and neurological damage following transient forebrain ischemia was studied in rats. The transient forebrain ischemia was induced by 4-vessel occlusion, and behavioral experiments were started 4 we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8701c9bddc27baa6b2bb8861c0fa58c
https://doi.org/10.1016/0006-8993(91)90443-y
https://doi.org/10.1016/0006-8993(91)90443-y
Publikováno v:
Neuroscience research. 64(1)
Although hypothermia is one of the most robust neuroprotectants clinically available, its underlying mechanisms remain unclear. Through microarray gene expression analysis, we previously identified several key molecules potentially involved in the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8569ef350a5ecb7c0a70a3107daf1f42
https://pubmed.ncbi.nlm.nih.gov/19428685
https://pubmed.ncbi.nlm.nih.gov/19428685
Publikováno v:
Thrombosis research. 79(1)
Effects of thromboxane A2 (TXA2) synthase inhibitors (CV-4151 and ozagrel) on cerebral thrombosis and cerebral damage were examined in a rat middle cerebral artery (MCA) thrombosis model and their potencies were compared with the conventional antithr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ebbe7170c81f3e4f0e41c62d6f5b74
https://pubmed.ncbi.nlm.nih.gov/7495108
https://pubmed.ncbi.nlm.nih.gov/7495108
Publikováno v:
Experimental Brain Research. 95
The objective of this study was to assess whether dimethylthiourea (DMTU), an established free radical scavenger, ameliorates ischaemic damage due to 2-3 h of transient middle cerebral artery (MCA) occlusion, induced by an intraluminal filament. A ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35ab3986e5c96b1f9b6ba2e5ffc85c2
https://doi.org/10.1007/bf00227131
https://doi.org/10.1007/bf00227131
Autor:
Akio Shino, Kenji Takami, Yoshihiro Kiyota, Koichi Igarashi, Masaya Tohyama, Akio Wanaka, Makoto Iwane, Masaomi Miyamoto, Ryoichi Tsukuda, Sadao Shiosaka
Publikováno v:
Experimental brain research. 97(2)
Recently, we demonstrated that transient forebrain ischemia in rats leads to an early and strong induction of basic fibroblast growth factor (bFGF) synthesis in astrocytes in the injured brain regions. In this study, in order to clarify the targets o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4c7a7a82a089d95ec0c3b090af93d9
https://pubmed.ncbi.nlm.nih.gov/8150041
https://pubmed.ncbi.nlm.nih.gov/8150041