Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yoshihiro Akahori"'
Autor:
Quentin M. R. Gibaut, Yoshihiro Akahori, Jessica A. Bush, Amirhossein Taghavi, Toru Tanaka, Haruo Aikawa, Lucas S. Ryan, Brian M. Paegel, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 144:21972-21979
A solid-phase DNA-encoded library (DEL) was studied for binding the RNA repeat expansion r(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d70cedce48e526c9dd48ea07de84a3
https://doi.org/10.1021/jacs.2c08883
https://doi.org/10.1021/jacs.2c08883
Autor:
Samantha M. Meyer, Toru Tanaka, Patrick R. A. Zanon, Jared T. Baisden, Daniel Abegg, Xueyi Yang, Yoshihiro Akahori, Zainab Alshakarchi, Michael D. Cameron, Alexander Adibekian, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 144:21096-21102
Ribonuclease targeting chimeras (RiboTACs) induce degradation of an RNA target by facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the screening of a DNA-encoded library (DEL) to identify binders of monomeric RNase L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fd2d6a6853884aaa97d960d447d4ac
https://doi.org/10.1021/jacs.2c07217
https://doi.org/10.1021/jacs.2c07217
Autor:
Yuquan Tong, Quentin M. R. Gibaut, Warren Rouse, Jessica L. Childs-Disney, Blessy M. Suresh, Daniel Abegg, Shruti Choudhary, Yoshihiro Akahori, Alexander Adibekian, Walter N. Moss, Matthew D. Disney
Publikováno v:
J Am Chem Soc
The interactions between cellular RNAs in MDA-MB-231 triple negative breast cancer cells and a panel of small molecules appended with a diazirine cross-linking moiety and an alkyne tag were probed transcriptome-wide in live cells. The alkyne tag allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6fb0cc19b69f65a725b2ce3892e36e
https://doi.org/10.1021/jacs.2c01929
https://doi.org/10.1021/jacs.2c01929
Autor:
Blessy M. Suresh, Yoshihiro Akahori, Amirhossein Taghavi, Gogce Crynen, Quentin M. R. Gibaut, Yue Li, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 144(45)
RNA is challenging to target with bioactive small molecules, particularly those of low molecular weight that bind with sufficient affinity and specificity. In this report, we developed a platform to address this challenge, affording a novel bioactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b07aaa55768e09e9f497219cf2f1097
https://pubmed.ncbi.nlm.nih.gov/36322830
https://pubmed.ncbi.nlm.nih.gov/36322830
Autor:
Yuquan Tong, Quentin M. R. Gibaut, Warren Rouse, Jessica L. Childs-Disney, Blessy M. Suresh, Daniel Abegg, Shruti Choudhary, Yoshihiro Akahori, Alexander Adibekian, Walter N. Moss, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 145:9364-9364
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6655ea99ffbc21a31fc5b8780e8dea9
https://doi.org/10.1021/jacs.3c02644
https://doi.org/10.1021/jacs.3c02644
Autor:
Yoshihiro Akahori, Jessica L. Childs-Disney, Toru Tanaka, Christopher C. Williams, Samantha M. Meyer, Haruo Aikawa, Matthew D. Disney, Yuquan Tong
Publikováno v:
Chem Soc Rev
Targeting RNAs with small molecules represents a new frontier in drug discovery and development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir of targets for small molecules to bind, similar to small molecule occupa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee6fed747a971c6ef1f36510d087fe9
https://pubmed.ncbi.nlm.nih.gov/32975549
https://pubmed.ncbi.nlm.nih.gov/32975549
Publikováno v:
Organic Letters. 16:2054-2057
A stereoselective synthesis of the CDE ring portion of the antitumor saponin scillascilloside E-1 has been achieved, utilizing an Ireland-Claisen rearrangement to construct the contiguous tetrasubstituted stereocenters at C13 and C17 simultaneously a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26d213d58f71df931e87d7dffc0fbdd
https://doi.org/10.1021/ol500657f
https://doi.org/10.1021/ol500657f
Publikováno v:
Organic letters. 18(14)
A stereoselective total synthesis of (+)-marrubiin has been accomplished starting from a chiral building block via the CyNH2-promoted Pauson–Khand reaction (PKR) followed by oxidative cleavage of the resultant cyclopentenone ring. Two successive ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d752b10c1087b7695c19cb2b558963
https://pubmed.ncbi.nlm.nih.gov/27341320
https://pubmed.ncbi.nlm.nih.gov/27341320
Publikováno v:
ChemInform. 45
A stereoselective synthesis of the CDE ring portion of the antitumor saponin scillascilloside E-1 has been achieved, utilizing an Ireland–Claisen rearrangement to construct the contiguous tetrasubstituted stereocenters at C13 and C17 simultaneously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6938f24b7ba9cd8962d228a352128e41
https://doi.org/10.1002/chin.201436202
https://doi.org/10.1002/chin.201436202
Publikováno v:
ChemInform. 45
Methods for highly stereocontrolled syntheses of chiral building blocks with a triad of contiguous stereocenters, including two quaternary ones, have been developed. Ireland–Claisen rearrangement of the (Z)-silyl ketene acetal generated stereoselec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ea6e68504b4f58dd202ac74ef651377
https://doi.org/10.1002/chin.201425038
https://doi.org/10.1002/chin.201425038