Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Yoshihiro, Aiba"'
Autor:
Yuki Hitomi, Yoshihiro Aiba, Kazuko Ueno, Nao Nishida, Yosuke Kawai, Minae Kawashima, Makoto Tsuiji, Chisato Iwabuchi, Sanami Takada, Noriko Miyake, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-12 (2022)
Abstract Background Ligation of CD28 with ligands such as CD80 or CD86 provides a critical second signal alongside antigen presentation by class II major histocompatibility complex expressed on antigen-presenting cells through the T cell antigen rece
Externí odkaz:
https://doaj.org/article/42bb9750cc5441d69b03584f5773a006
Autor:
Seik-Soon Khor, Kazuko Ueno, Nao Nishida, Minae Kawashima, Yosuke Kawai, Yoshihiro Aiba, Yuki Hitomi, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Primary biliary cholangitis (PBC) is a rare autoimmune disease with a clear predisposition for human leukocyte antigen (HLA)-DR/DQ-associated loss of immune tolerance for the E2 component of the pyruvate dehydrogenase complex. Three-field-resolution
Externí odkaz:
https://doaj.org/article/5083101fae4c4d3e8bfcee12a4a3bd7c
Autor:
Yuki Hitomi, Yoshihiro Aiba, Yosuke Kawai, Kaname Kojima, Kazuko Ueno, Nao Nishida, Minae Kawashima, Olivier Gervais, Seik-Soon Khor, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, Makoto Tsuiji
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which intrahepatic bile ducts are destroyed by an autoimmune reaction. Our previous genome-wide association study (GWAS) identified chromosome 11q23.1 a
Externí odkaz:
https://doaj.org/article/cb5d749009044cbb96285ad674364512
Autor:
Kazuko Ueno, Yoshihiro Aiba, Yuki Hitomi, Shinji Shimoda, Hitomi Nakamura, Olivier Gervais, Yosuke Kawai, Minae Kawashima, Nao Nishida, Seik‐Soon Kohn, Kaname Kojima, Shinji Katsushima, Atsushi Naganuma, Kazuhiro Sugi, Tatsuji Komatsu, Tomohiko Mannami, Kouki Matsushita, Kaname Yoshizawa, Fujio Makita, Toshiki Nikami, Hideo Nishimura, Hiroshi Kouno, Hirotaka Kouno, Hajime Ohta, Takuya Komura, Satoru Tsuruta, Kazuhiko Yamauchi, Tatsuro Kobata, Amane Kitasato, Tamotsu Kuroki, Seigo Abiru, Shinya Nagaoka, Atsumasa Komori, Hiroshi Yatsuhashi, Kiyoshi Migita, Hiromasa Ohira, Atsushi Tanaka, Hajime Takikawa, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, PBC‐GWAS Consortium in Japan
Publikováno v:
Hepatology Communications, Vol 4, Iss 5, Pp 724-738 (2020)
Genome‐wide association studies (GWASs) in European and East Asian populations have identified more than 40 disease‐susceptibility genes in primary biliary cholangitis (PBC). The aim of this study is to computationally identify disease pathways,
Externí odkaz:
https://doaj.org/article/fe46dbbb09334b3f85f5095abc8398e3
Autor:
Yuki Hitomi, Ken Nakatani, Kaname Kojima, Nao Nishida, Yosuke Kawai, Minae Kawashima, Yoshihiro Aiba, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 515-532 (2019)
Background & Aims: Primary biliary cholangitis (PBC) is a chronic and cholestatic liver disease that eventually leads to cirrhosis and hepatic failure. We recently identified several susceptibility genes included NFKB1 and MANBA for PBC in the Japane
Externí odkaz:
https://doaj.org/article/7d139b2e085d4d1b96217aa1a699886e
Autor:
Kiyoshi Migita, Minoru Nakamura, Yoshihiro Aiba, Hideko Kozuru, Seigo Abiru, Atsumasa Komori, Yuya Fujita, Junpei Temmoku, Tomoyuki Asano, Shuzo Sato, Makiko Furuya, Atsushi Naganuma, Kaname Yoshizawa, Masaaki Shimada, Keisuke Ario, Tomohiko Mannami, Hiroshi Kohno, Toshihiko Kaneyoshi, Takuya Komura, Hiromasa Ohira, Hiroshi Yatsuhashi
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0238540 (2020)
BackgroundAutoimmune hepatitis (AIH) is a disorder of unknown etiology in which immune-mediated liver injury progress to cirrhosis or hepatocellular carcinoma (HCC). The aim of the present study was to determine whether circulating soluble TIM3 (sTIM
Externí odkaz:
https://doaj.org/article/5b22f2ff2b9142a79bc8da3effb54bb2
Autor:
Yuki Hitomi, Kaname Kojima, Minae Kawashima, Yosuke Kawai, Nao Nishida, Yoshihiro Aiba, Michio Yasunami, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Numerous genome-wide association studies (GWAS) have been performed to identify susceptibility genes to various human complex diseases. However, in many cases, neither a functional variant nor a disease susceptibility gene have been clarifie
Externí odkaz:
https://doaj.org/article/54c3410024dd41879c28cdfb95e290ec
Autor:
Masao Nagasaki, Yoshihiro Aiba, Minoru Nakamura, Kazuko Ueno, Yuki Hitomi, Yosuke Kawai, Mayumi Ueta, Katsushi Tokunaga, Olivier Gervais
Publikováno v:
European Journal of Human Genetics
While the advent of GWAS more than a decade ago has ushered in remarkable advances in our understanding of complex traits, the limitations of single-SNP analysis have also led to the development of several other approaches. Simulation studies have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263f9f2c0b076b47cd2643ef8449db0f
http://hdl.handle.net/2433/262593
http://hdl.handle.net/2433/262593
Autor:
Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Nao Nishida, Seik-Soon Khor, Olivier Gervais, Yosuke Kawai, Masao Nagasaki, Katsushi Tokunaga, Ruqi Tang, Yongyong Shi, Zhiqiang Li, Brian D. Juran, Elizabeth J. Atkinson, Alessio Gerussi, Marco Carbone, Rosanna Asselta, Angela Cheung, Mariza de Andrade, Aris Baras, Julie Horowitz, Manuel A.R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Ann Spicer, Victoria L. Mulcahy, Jinyoung Byan, Younghun Han, Richard N. Sandford, Konstantinos N. Lazaridis, Christopher I. Amos, Gideon M. Hirschfield, Michael F. Seldin, Pietro Invernizzi, Katherine A. Siminovitch, Xiong Ma, Minoru Nakamura, George F. Mells
Publikováno v:
Journal of Hepatology. 78:883
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca9b35e58bf43ef325be75ca1740a59b
https://doi.org/10.1016/j.jhep.2022.12.001
https://doi.org/10.1016/j.jhep.2022.12.001
Autor:
Toshiki Nikami, Hitomi Nakamura, Takuya Komura, Yuki Hitomi, Kiyoshi Migita, Atsushi Naganuma, Amane Kitasato, Olivier Gervais, Hiroshi Kouno, Atsumasa Komori, Hiromasa Ohira, Minae Kawashima, Hajime Ohta, Seigo Abiru, Yosuke Kawai, Shinji Katsushima, Kaname Yoshizawa, Kazuko Ueno, Hideo Nishimura, Masao Nagasaki, Tamotsu Kuroki, Tatsuji Komatsu, Katsushi Tokunaga, Hajime Takikawa, Shinya Nagaoka, Kazuhiko Yamauchi, Tomohiko Mannami, Seik-Soon Kohn, Kouki Matsushita, Tatsuro Kobata, Hirotaka Kouno, Nao Nishida, Satoru Tsuruta, Fujio Makita, Atsushi Tanaka, Hiroshi Yatsuhashi, Shinji Shimoda, Yoshihiro Aiba, Kazuhiro Sugi, Kaname Kojima, Minoru Nakamura
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 4, Iss 5, Pp 724-738 (2020)
Hepatology Communications, Vol 4, Iss 5, Pp 724-738 (2020)
Genome‐wide association studies (GWASs) in European and East Asian populations have identified more than 40 disease‐susceptibility genes in primary biliary cholangitis (PBC). The aim of this study is to computationally identify disease pathways,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22c6be131c644f6d3ed48a91aeb1f4a
https://doi.org/10.1002/hep4.1497
https://doi.org/10.1002/hep4.1497