Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Yoshihiko Miyata"'
Autor:
Sofia Zanin, Christian Borgo, Cristina Girardi, Sean E O'Brien, Yoshihiko Miyata, Lorenzo A Pinna, Arianna Donella-Deana, Maria Ruzzene
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49193 (2012)
CK2 is a pleiotropic protein kinase, which regulates many survival pathways and plays a global anti-apoptotic function. It is highly expressed in tumor cells, and is presently considered a promising therapeutic target. Among the many inhibitors avail
Externí odkaz:
https://doaj.org/article/1628c93d81e54239a1197f03df0b6790
Autor:
Yoshihiko Miyata, Eisuke Nishida
Publikováno v:
Life Science Alliance; Dec2023, Vol. 6 Issue 12, p1-17, 17p
Autor:
Yoshihiko Miyata, Eisuke Nishida
A protein kinase DYRK1A encoded in human chromosome-21 is the major contributor for multiple symptoms observed in Down syndrome patients. In addition, DYRK1A dysfunction has been associated with various neuronal disorders, including autism spectrum d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d197358fbb5419a27cfc9b4668d4ece7
https://doi.org/10.1101/2023.04.21.537794
https://doi.org/10.1101/2023.04.21.537794
Autor:
Jesús A. Pérez-Cabello, Lucía Silvera-Carrasco, Jaime M. Franco, Vivian Capilla-González, Alexandros Armaos, María Gómez-Lima, Raquel García-García, Xin Wen Yap, M. Magdalena Leal-Lasarte, Deepti Lall, Robert H. Baloh, Salvador Martínez, Yoshihiko Miyata, Gian G. Tartaglia, Ritwick Sawarkar, Mario García-Dominguez, David Pozo, Cintia Roodveldt
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease affecting motor neurons and characterized by microglia-mediated neurotoxic inflammation whose underlying mechanisms remain incompletely understood. In this work we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::009874c33f6e71a3dc6ed51509372f09
https://doi.org/10.1101/2023.01.23.524851
https://doi.org/10.1101/2023.01.23.524851
Autor:
Pérez-Cabello, Jesús A., Silvera-Carrasco, Lucía, Franco, Jaime M., Capilla-González, Vivian, Armaos, Alexandros, Gómez-Lima, María, García-García, Raquel, Xin Wen Yap, Leal-Lasarte, Magdalena, Lall, Deepti, Baloh, Robert H., Martínez, Salvador, Yoshihiko Miyata, Tartaglia, Gian G., Sawarkar, Ritwick, García-Domínguez, Mario, Pozo, David, Roodveldt, Cintia
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 7/11/2023, Vol. 120 Issue 28, p1-11, 34p
Autor:
Yoshihiko Miyata, Katsumi Matsuzaki, Mami Yamamoto, Toshimichi Fujiwara, Chojiro Kojima, Masaru Hoshino, Futoshi Ihama
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1867:813-820
Cdc37 is a protein kinase-targeting molecular chaperone, which cooperates with Hsp90 to assist the folding, assembly and maturation of various signaling kinases. It consists of three distinct domains: the N-terminal, middle, and C-terminal domain. Wh
Autor:
Hitoshi Nakamoto, Takashi Fujishiro, Yuhei Yokoyama, Yuri Miyamoto, Masaaki Morikawa, Takahiro Suzuki, Yoshihiko Miyata
Publikováno v:
Journal of biochemistry. 170(2)
Heat shock protein 90 (Hsp90) is essential for eukaryotic cells, whereas bacterial homologs play a role under stresses and in pathogenesis. Identifying species-specific Hsp90 inhibitors is challenging because Hsp90 is evolutionarily conserved. We fou
Autor:
Taiwa Komatsu, Ibrahim Jantan, Naoshi Dohmae, Yoshihiko Miyata, Yosuke Amaya, Yusuke Nakamura, Takehiro Suzuki, Hitoshi Nakamoto
Publikováno v:
Biochemical Journal. 475:2559-2576
Hsp90 is an ATP-dependent molecular chaperone that assists folding and conformational maturation/maintenance of many proteins. It is a potential cancer drug target because it chaperones oncoproteins. A prokaryotic homolog of Hsp90 (HtpG) is essential
Autor:
Yoshihiko Miyata, Eisuke Nishida
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1868:119081
The DYRK (Dual-specificity tYrosine-phosphorylation Regulated protein Kinase) family consists of five related protein kinases (DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4). DYRKs show homology to Drosophila Minibrain, and DYRK1A in human chromosome 21 is res
Publikováno v:
BioMed Research International, Vol 2015 (2015)
BioMed Research International
BioMed Research International
After 60 years from the first report of an enzymatic phosphorylation of proteins, protein kinases are well-established key signaling molecules that impact all major biological processes (reviewed in [1, 2]). Protein and lipid kinases fulfill essentia