Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yoshihiko Ishitani"'
Autor:
Akira Kawase, Yoshihiko Ishitani, Hiroyoshi Watanabe, Tetsuya Mitsui, Noboru Kubodera, Ken Okano, Kazumi Morikawa
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 42:519-525
The synthesis of tritiated 1α-25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71), [2β-(3-3H)]ED-71 ((3) and [26,27-3H6]ED-71 (4) is described. The former was prepared by reduction of a precausor containing a formyl group in the A-ring part with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3824021f4dbc6f1f3c327fb9b53b86cb
https://doi.org/10.1002/(sici)1099-1344(199906)42:6<519::aid-jlcr213>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199906)42:6<519::aid-jlcr213>3.0.co
Autor:
Toshito Nakagawa, Kazumi Ohkubo, Akira Okazaki, Masaki Ishigai, Yuka Hiramatsu, Yoshihiko Ishitani
Publikováno v:
Drug Metabolism and Pharmacokinetics. 10:625-636
The metabolism of 14C labeled Q-35 [(±)-1-cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7 (3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid], a new fluoroquinolone antimicrobial agent, was studied in rats and dogs.1. Two metabolites were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6089d14648d82ce0bc3166dec9eb742
https://doi.org/10.2133/dmpk.10.625
https://doi.org/10.2133/dmpk.10.625
Autor:
Ken Okano, Norihisa Ohishi, Satofumi Iida, Tsuneo Okutomi, Masaki Ishigai, Akira Okazaki, Toshito Nakagawa, Masami Hayashi, Yoshihiko Ishitani
Publikováno v:
Drug Metabolism and Pharmacokinetics. 10:617-624
Transfer of radioactivity into fetus and milk were studied after a single oral administration of 14C-Q-35 at the dose of 20 mg/kg in pregnant and in lactating rats.1. Whole body autoradiography of pregnant rats showed that radioactivity distributed w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed84b107ea6c3ecc09dc38f6418b35a
https://doi.org/10.2133/dmpk.10.617
https://doi.org/10.2133/dmpk.10.617
Autor:
Yoshio Esumi, Hidetaka Suzuki, Hiroyuki Nemoto, Yoshitomo Kasuga, Yoshitaka Jin, Kazumi Ohkubo, Masaki Ishigai, Yuko Nomiyama, Yoshihiko Ishitani, Naohiko Hayakawa, Hiroshi Kamiyama, Akira Okazaki, Tetsuya Mitsui, Toshito Nakagawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 10:604-616
The distribution of radioactivity after a single and repeated oral administration of 14C labeled Q-35[(±)-1-cyclopropyl-6-fluoro-1, 4 dihydro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid], a new fluoroquinolone antimicr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d56a632a6abb88cb569679394136818
https://doi.org/10.2133/dmpk.10.604
https://doi.org/10.2133/dmpk.10.604
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 66(5-6)
After intravenous administration of the vitamin D3 analog, 22-oxacalcitriol (OCT), to normal rats plasma metabolites were investigated by HPLC, GC-MS and LC-MS. Five side-chain oxidation metabolites, 24R(OH)OCT, 24S(OH)OCT, (25R)-26(OH)OCT, (25S)-26(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad99137edf5f236af3ac094a1d6abf9
https://pubmed.ncbi.nlm.nih.gov/9749834
https://pubmed.ncbi.nlm.nih.gov/9749834
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 704(1-2)
The characteristics of the mass spectra of vitamin D3 related compounds were investigated by GC-MS and LC-MS using 22-oxacalcitriol (OCT), an analog of 1,25-dihydroxyvitamin D3, and related compounds. Fragmentation during GC-MS (electron impact ioniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1e4a1539923e87c5fc41c2487f6ff7
https://pubmed.ncbi.nlm.nih.gov/9518141
https://pubmed.ncbi.nlm.nih.gov/9518141