Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Yoshihiko Hagiwara"'
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0232047 (2020)
Spontaneous testicular teratomas (STTs) derived from primordial germ cells (PGCs) in the mouse embryonic testes predominantly develop in the 129 family inbred strain. Ter (spontaneous mutation) is a single nucleotide polymorphism that generates a pre
Externí odkaz:
https://doaj.org/article/b6facd5a1a2e4413b041da5e1515b93b
Autor:
Hiro Sato, Atsuko Niimi, Takaaki Yasuhara, Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Mayu Isono, Endang Nuryadi, Ryota Sekine, Takahiro Oike, Sangeeta Kakoti, Yuya Yoshimoto, Kathryn D. Held, Yoshiyuki Suzuki, Koji Kono, Kiyoshi Miyagawa, Takashi Nakano, Atsushi Shibata
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
PD-L1 is upregulated in many cancers due to exogenous cellular stress. Here the authors show that PD-L1 is upregulated in response to DNA double strand breaks via STAT and IRF1 signalling.
Externí odkaz:
https://doaj.org/article/3aa563dc071243218d3b85fb984faf73
Autor:
Mayu Isono, Atsuko Niimi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano, Atsushi Shibata
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 520-532 (2017)
Summary: BRCA1 promotes homologous recombination (HR) by activating DNA-end resection. By contrast, 53BP1 forms a barrier that inhibits DNA-end resection. Here, we show that BRCA1 promotes DNA-end resection by relieving the 53BP1-dependent barrier. W
Externí odkaz:
https://doaj.org/article/c08217bfe8ec48588e34eb2bb7114e08
Autor:
Nakako Izumi Nakajima, Yoshihiko Hagiwara, Takahiro Oike, Ryuichi Okayasu, Takeshi Murakami, Takashi Nakano, Atsushi Shibata
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122582 (2015)
The choice of DNA double strand break (DSB) repair pathway is determined at the stage of DSB end resection. Resection was proposed to control the balance between the two major DSB repair pathways, homologous recombination (HR) and non-homologous end
Externí odkaz:
https://doaj.org/article/f0c720d1b2eb43a987a2d67a35fabdd9
Autor:
Takashi Nakano, Tiara Bunga Mayang Permata, Soehartati Gondhowiardjo, Atsushi Shibata, Takahiro Oike, Kathryn D. Held, Takaaki Yasuhara, Hiro Sato, Yoshihiko Hagiwara
Publikováno v:
Oncogene. 38:4452-4466
Programmed death-ligand 1 (PD-L1) is a key factor influencing cancer immunotherapy; however, the regulation of PD-L1 expression in cancer cells remains unclear, particularly regarding DNA damage, repair and its signalling. Herein, we demonstrate that
Autor:
Siripan Limsirichaikul, Kathryn D. Held, Atsuko Niimi, Motohiro Yamauchi, Takahiro Oike, Takashi Nakano, Atsushi Shibata, Hiro Sato, Yoshihiko Hagiwara
Publikováno v:
Journal of Radiation Research
Photons, such as X- or γ-rays, induce DNA damage (distributed throughout the nucleus) as a result of low-density energy deposition. In contrast, particle irradiation with high linear energy transfer (LET) deposits high-density energy along the parti
Autor:
Atsuko Niimi, Tiara Bunga Mayang Permata, Motohiro Yamauchi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Atsushi Shibata, Takashi Nakano
Publikováno v:
Human Immunology. 79:627-631
Programmed cell death-1 (PD-1) and its ligand (programmed death-ligand 1, PD-L1) are key factors that regulate a cytotoxic immune reaction. Anti-PD-1 therapy provides significant clinical benefits for patients with cancer, even those with advanced-st
Autor:
Mayu Isono, Takahiro Oike, Takaaki Yasuhara, Atsushi Shibata, Atsuko Niimi, Kathryn D. Held, Hiro Sato, Siripan Limsirichaikul, Takashi Nakano, Yoshihiko Hagiwara, Motohiro Yamauchi
Publikováno v:
Oncotarget
DNA double-strand breaks (DSBs) induced by ionising radiation are considered the major cause of genotoxic mutations and cell death. While DSBs are dispersed throughout chromatin after X-rays or γ-irradiation, multiple types of DNA damage including D
Autor:
Sangeeta Kakoti, Wenchao Gu, Atsushi Shibata, Siddhartha Laskar, Takashi Nakano, Takahiro Oike, Hiro Sato, Takaaki Yasuhara, Reona Kato, Kathryn D. Held, Yoshihiko Hagiwara, Motohiro Yamauchi
Publikováno v:
Oncology Reports
Ribosomes are important cellular components that maintain cellular homeostasis through overall protein synthesis. The nucleolus is a prominent subnuclear structure that contains ribosomal DNA (rDNA) encoding ribosomal RNA (rRNA), an essential compone
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0232047 (2020)
PLoS ONE, Vol 15, Iss 4, p e0232047 (2020)
Spontaneous testicular teratomas (STTs) derived from primordial germ cells (PGCs) in the mouse embryonic testes predominantly develop in the 129 family inbred strain. Ter (spontaneous mutation) is a single nucleotide polymorphism that generates a pre