Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Yoshihiko, Kakinuma"'
Autor:
Yohei Hasebe, Shigefumi Yokota, Isato Fukushi, Kotaro Takeda, Masashi Yoshizawa, Hiroshi Onimaru, Yosuke Kono, Shuei Sugama, Makoto Uchiyama, Keiichi Koizumi, Jouji Horiuchi, Yoshihiko Kakinuma, Mieczyslaw Pokorski, Takako Toda, Masahiko Izumizaki, Yasuo Mori, Kanji Sugita, Yasumasa Okada
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract The reflexive excitation of the sympathetic nervous system in response to psychological stress leads to elevated blood pressure, a condition that persists even after the stress has been alleviated. This sustained increase in blood pressure,
Externí odkaz:
https://doaj.org/article/61ee79de8ffe4646b1aa5c191ca4944d
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Diabetic heart disease remains the leading cause of death in individuals with type-2 diabetes mellitus (T2DM). Both insulin resistance and metabolic derangement, hallmark features of T2DM, develop early and progressively impair cardiovascular functio
Externí odkaz:
https://doaj.org/article/055a2c88443643e1b6c133bccadf07c6
Autor:
Takashi Sonobe, Yoshihiko Kakinuma
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Vascular endothelial cells play an important role in regulating peripheral circulation by modulating arterial tone in the microvasculature. Elevated intracellular Ca2+ levels are required in endothelial cells to induce smooth muscle relaxation via en
Externí odkaz:
https://doaj.org/article/66afcf96db9b4b8380be38741f9d6e5c
Autor:
Yoshihiko Kakinuma
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
The non-neuronal cholinergic system of the cardiovascular system has recently gained attention because of its origin. The final product of this system is acetylcholine (ACh) not derived from the parasympathetic nervous system but from cardiomyocytes,
Externí odkaz:
https://doaj.org/article/69161adbfbf846ceaf21284149e375f2
Publikováno v:
PPAR Research, Vol 2024 (2024)
We have previously reported the identification of a novel splicing variant of the mouse peroxisome proliferator-activated receptor-γ (Pparγ), referred to as Pparγ1sv. This variant, encoding the PPARγ1 protein, is abundantly and ubiquitously expre
Externí odkaz:
https://doaj.org/article/8cd965d0a5f349c2a603115bbe15bcf4
Autor:
Pujika Emani Munasinghe, Eng Leng Saw, Matthew Reily-Bell, Devin Tonkin, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katare
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e17434- (2023)
Aims: Type 1 diabetes mellitus (T1DM) is associated with increased risk of cardiovascular disease (CVD) and mortality. The underlying mechanisms for T1DM-induced heart disease still remains unclear. In this study, we aimed to investigate the effects
Externí odkaz:
https://doaj.org/article/a671ad6dd81c4424bd1030fea1887c5c
Publikováno v:
Frontiers in Cardiovascular Medicine; 2024, p1-7, 7p
Publikováno v:
FEBS Open Bio, Vol 12, Iss 1, Pp 250-257 (2022)
Acetylcholine (ACh), an excitatory neurotransmitter, is biosynthesized from choline in cholinergic neurons. Import from the extracellular space to the intracellular environment through the high‐affinity choline transporter is currently regarded to
Externí odkaz:
https://doaj.org/article/071dbb74268b4326ad0804956b29d31f
Autor:
Eng Leng Saw, James T. Pearson, Daryl O. Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J. A. Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katare
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-16 (2021)
Abstract Background Acetylcholine (ACh) plays a crucial role in the function of the heart. Recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (NNCS) that comprises of choline acetyltransferase (ChAT), choline trans
Externí odkaz:
https://doaj.org/article/a7945995bbd64248a9c867a8dfe3eb4d
Autor:
Shuei Sugama, Takato Takenouchi, Makoto Hashimoto, Hisayuki Ohata, Yasuhiro Takenaka, Yoshihiko Kakinuma
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-16 (2019)
Abstract Background The involvement of microglia in neuroinflammatory responses has been extensively demonstrated. Recent animal studies have shown that exposure to either acute or chronic stress induces robust microglial activation in the brain. In
Externí odkaz:
https://doaj.org/article/c7198fc38dea4a41a5242261f338f6e1