Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yoshihide Nakano"'
Autor:
Yoshihide Nakano, Tsuyoshi Maekawa, Takashi Nakahata, Masanori Watanabe, Shinji Iwasaki, Sachie Morimoto, Asato Kina, Shizuo Kasai, Nobuyuki Takakura, Takeshi Yamasaki, Yuji Shimizu, Yumiko Okano Tamura, Tohru Yamashita, Tomoyuki Odani, Jun Sugama, Hideki Hirose
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:4153-4162
Somatostatin (SST) is a peptide hormone comprising 14 or 28 amino acids that inhibits endocrine and exocrine secretion via five distinct G-protein-coupled receptors (SSTR1-5). SSTR5 has an important role in inhibiting the secretion of pancreatic and
Autor:
Arunima Pola, Suresh An, Sadananthan, Venkatesh Gopalan, Min-Li Sandra Tan, Terry Yew Keong, Zhihong Zhou, Seigo Ishino, Yoshihide Nakano, Masanori Watanabe, Takashi Horiguchi, Tomoyuki Nishimoto, Bin Zhu, S. Sendhil Velan
Publikováno v:
Magnetic Resonance Insights, Vol 2014, Iss 7, Pp 33-40 (2014)
Autor:
Mariko Yoneyama-Hirozane, Shiro Takekawa, Junichi Sakamoto, Kenichi Imahashi, Tsuyoshi Ishii, Junji Matsui, Yoshihide Nakano, Takeshi Hirakawa, Kohei Deguchi, Tomoyuki Odani, Ikumi Chisaki, Nobuyuki Takakura
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(2)
Ghrelin O-acyl transferase (GOAT; MBOAT4) catalyzes O-acylation at serine-3 of des-acyl ghrelin. Acyl ghrelin is secreted by stomach X/A-like cells and plays a role in appetite and metabolism. Therefore, GOAT has been expected to be a novel antiobesi
Autor:
Shinji Iwasaki, Shizuo Kasai, Ryo Mizojiri, Tsuyoshi Maekawa, Akito Hata, Yoshihide Nakano, Masaki Ogino, Yumiko Tamura-Okano, Masanori Watanabe, Takeshi Yamasaki, Hideki Hirose, Jun Sugama, Yo Muraki, Hiroaki Yashiro
Publikováno v:
Bioorganicmedicinal chemistry. 25(15)
Somatostatin receptor subtype 5 (SSTR5) has emerged as a novel attractive drug target for type 2 diabetes mellitus. Starting from N-benzyl azetidine derivatives 1 and 2 as in-house hit compounds, we explored the introduction of a carboxyl group into
Autor:
Naoki Furuyama, Asato Kina, Atsushi Mizukami, Makoto Kamata, Akiyoshi Tani, Miyuki Funami, Michiko Tawada, Kohji Fukatsu, Tohru Yamashita, Nobuyuki Amano, Yuuki Watanabe, Satoshi Endo, Masako Sasaki, Yoshihide Nakano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4769-4772
Spiro-pyrazolidinedione derivatives without quaternary chiral center were discovered by structure-based drug design and characterized as potent acetyl-CoA carboxylase (ACC) inhibitors. The high metabolic stability of the spiro-pyrazolo[1,2-a]pyridazi
Autor:
Yuji Ishihara, Ryoma Hara, Kaneyoshi Kato, Asano Asami, Toshiro Yamashita, Shigekazu Sasaki, Shiro Takekawa, Hitomi Ogino, Nobuhiro Suzuki, Shuntaro Ashina, Yoshihide Nakano, Masahiro Kamaura, Tomoko Kaisho, Shizuo Kasai, Toshio Tanaka, Koki Kato, Shinichi Masada, Toshihiro Imaeda, Yasutaka Nagisa, Makoto Kamata
Publikováno v:
Journal of Medicinal Chemistry. 55:2353-2366
It was found that 3-(aminomethyl)quinoline derivatives showed high binding affinities for melanin-concentrating hormone receptor 1 (MCHR1) with reduced affinity for serotonin receptor 2c (5-HT2c) when the dihydronaphthalene nucleus of compound 1 (hum
Autor:
Toshio Tanaka, Satoshi Endo, Nobuhiro Suzuki, Jun Terauchi, Yoshihide Nakano, Maki Miyamoto, Kaoru Watanabe, Makoto Kamata, Hitomi Ogino, Shiro Takekawa, Asano Asami, Toshiro Yamashita, Michiko Tawada, Koki Kato, Yasutaka Nagisa, Kaneyoshi Kato, Yuji Ishihara, Toshihiro Imaeda, Taiichi Ora
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5539-5552
Human melanin-concentrating hormone receptor 1 (hMCHR1) antagonists are promising targets for obesity treatment. We identified the tetrahydronaphthalene derivative 1a with modest binding affinity for hMCHR1 by screening an in-house G protein-coupled
Autor:
Todd D. Williams, Joel K. Elmquist, Amanda R. Waxman, Jeffrey M. Zigman, Juli E. Jones, Charlotte E. Lee, Yoshihide Nakano, Nina Balthasar, Bradford B. Lowell, Amy E. Deysher, Jennifer Lachey, Randy J. Seeley, Jacob Marcus, Roberto Coppari, Ryan D. White
Publikováno v:
Journal of Clinical Investigation. 115:3564-3572
Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR; ghrelin receptor). Since its discovery, accumulating evidence has suggested that ghrelin may play a role in signaling and reversing states of energy insufficiency. F
Autor:
Akemichi Baba, Toshio Matsuda, Mitsuo Egawa, Yoshihide Nakano, Shoichi Asano, Hye Sun Kim, Makoto Suzuki, Pranee Somboonthum, Yukiko Nakasu, Kazuhiro Takuma, Akihiro Tobe, Takashi Yoshikawa, Tomoko Morita
Publikováno v:
Japanese Journal of Pharmacology. 69:357-366
The present study characterizes the neurochemical profile of the newly synthesized compound 5-{3-[((2S)-1, 4-benzodioxan-2-ylmethyl)amino]propoxy}-1, 3-benzodioxole HC1 (MKC-242). In in vitro experiments, MKC-242 had high affinity for serotonin1A (5-
Autor:
Tomohiro Okawa, Shiro Takekawa, Kazuaki Takami, Koki Kato, Yumi N. Imai, Sunghi Ryu, Makoto Kamata, Jun Kunitomo, Masaharu Nakayama, Shinichi Masada, Nobuhiro Suzuki, Yoshihide Nakano, Toshiki Murata, Masahiro Kamaura, Yuji Ishihara, Kaoru Watanabe, Hitomi Ogino, Shizuo Kasai, Yasutaka Nagisa, Tomoko Kaisho, Shuntarou Ashina
Publikováno v:
Journal of medicinal chemistry. 55(9)
Recently, we discovered 3-aminomethylquinoline derivative 1, a selective, highly potent, centrally acting, and orally bioavailable human MCH receptor 1 (hMCHR1) antagonist, that inhibited food intake in F344 rats with diet-induced obesity (DIO). Subs