Zobrazeno 1 - 10 of 194 pro vyhledávání: '"Yoshiharu Machida"'
1
Akademický článek
Determination of metronidazole in a rat stomach by HPLC for obtaining basic data of the eradication therapy of Helicobacter pylori
Autor: Mai Kubodera, Tadakazu Tokumura, Yoshiharu Machida
Publikováno v: Journal of Pharmaceutical Analysis, Vol 2, Iss 5, Pp 378-381 (2012)
In the eradication therapy of Helicobacter pylori changes of antibiotics as these concentrations or amount in the stomach after oral administration were not clear. A simple and accurate method for determining the concentration of metronidazole (MTZ)
Externí odkaz: https://doaj.org/article/09f212c9dbde4e2395f32e76d439c8e8
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2
Akademický článek
In Vitro and In Vivo Evaluation of Microparticulate Drug Delivery Systems Composed of Macromolecular Prodrugs
Autor: Yoshiharu Machida, Hiraku Onishi
Publikováno v: Molecules, Vol 13, Iss 9, Pp 2136-2155 (2008)
Macromolecular prodrugs are very useful systems for achieving controlled drug release and drug targeting. In particular, various macromolecule-antitumor drug conjugates enhance the effectiveness and improve the toxic side effects. Also, polymeric mic
Externí odkaz: https://doaj.org/article/5b29509a063b4de6a73d561c4163a671
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4
Enhancement Potential of Sucrose Laurate (L-1695) on Intestinal Absorption of Water-Soluble High Molecular Weight Compounds
Autor: Hiraku Onishi, Yu Imura, Minoru Uchida, Yoshiharu Machida
Publikováno v: Current Drug Delivery. 9:487-494
Purpose: The potential of sucrose fatty acid esters (SEs) to enhance intestinal absorption was investigated in order to identify their utility for the intestinal absorption of water-soluble high molecular weight compounds. Methods: Fluorescein isothi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6de4711cc634213e2cfe783ac991e7e
https://doi.org/10.2174/156720112802650699
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6
Kinetic analysis of in vitro and in vivo release of prednisolone from the conjugate of glycol-chitosan and succinyl-prednisolone
Autor: Yuta Saito, Hiraku Onishi, Masanaho Sasatsu, Yoshiharu Machida
Publikováno v: International Journal of Pharmaceutics. 410:17-22
Recently, many people have developed rheumatoid arthritis (RA), and prednisolone (PD) is often used for treatment; however, long use and a large dose of PD can cause toxic side effects. In this study, in order to enhance the therapeutic effects and t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71b1b48757e230d3fdfecc841eaecf9
https://doi.org/10.1016/j.ijpharm.2011.03.004
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7
Preparation and Evaluation of Taste Masked Orally Disintegrating Tablets with Granules Made by the Wet Granulation Method
Autor: Masanaho Sasatsu, Hiraku Onishi, Akihiko Ito, Yayoi Kawano, Yoshiharu Machida
Publikováno v: YAKUGAKU ZASSHI. 130:1737-1742
Using furosemide (FU) as a model drug, we examined the wet granulation method as a way to improve the taste masking and physical characteristics of orally disintegrating tablets (ODTs). In the wet granulation method, yogurt powder (YO) was used as a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3213c3d29dfe71b99c1aec7af2e248
https://doi.org/10.1248/yakushi.130.1737
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8
Effect of β-Cyclodextrin on the Degradation Rate of Amoxicillin in Acidic Solution
Autor: Toyofumi Suzuki, Haruhisa Ueda, Kazuo Tomono, Yoshiharu Machida, Tsuneji Nagai, Rieko Nakane, Shinji Hidaka, Tadakazu Tokumura, Masashi Nagaoka
Publikováno v: YAKUGAKU ZASSHI. 130:889-893
The formation of an inclusion complex of amoxicillin (AMX) with beta-cyclodextrin (beta-CD) in aqueous solution was confirmed by a solubility method and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The apparent stability constant for the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d9b8d33df1b60e6a9c748ebdf86aba
https://doi.org/10.1248/yakushi.130.889
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9
Preparation of Rapidly Disintegrating Tablets Containing Precipitated Calcium Carbonate by Direct Compression Method
Autor: Akihiko Ito, Masanaho Sasatsu, Yoshiharu Machida, Yayoi Kawano
Publikováno v: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 36:705-710
Microcrystalline cellulose (Avicel®PH-302),lactose (Super-Tab®),carboxymethyl cellulose (CMC) and xylitol are added to tablet formulations of precipitated calcium carbonate to achieve rapid disintegration while maintaining sufficient tensile streng
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::973acdcc7121b8622df3a655c01199df
https://doi.org/10.5649/jjphcs.36.705
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10
Preparation and Evaluation of Taste Masked Orally Disintegrating Tablets with Granules Made by the Wet Granulation Method Using Mixtures of Yogurt Powder and Maltitol
Autor: Yayoi Kawano, Hiraku Onishi, Yoshiharu Machida, Akihiko Ito, Masanaho Sasatsu
Publikováno v: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 36:780-785
We investigated the preparation of orally disintegrating tablets (ODTs) using furosemide (FU) as a model drug.Preparations were made from granules containing 2 correctives,maltitol (MA) and yogurt powder (YO),in various mixing ratios formed by the we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4192f1f4a7a80400f11d4dfb481ae9c3
https://doi.org/10.5649/jjphcs.36.780
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