Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Yoshifusa Tobe"'
Autor:
Haruo Imawaka, Ryuta Asaumi, Kenta Hashizume, Ken-ichi Nunoya, Kota Toshimoto, Yoshifusa Tobe, Wooin Lee, Yuichi Sugiyama
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 7:186-196
This study aimed to construct a physiologically based pharmacokinetic (PBPK) model of rifampicin that can accurately and quantitatively predict complex drug-drug interactions (DDIs) involving its saturable hepatic uptake and auto-induction. Using in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39397da43dcfb4754eec152317434082
https://doi.org/10.1002/psp4.12275
https://doi.org/10.1002/psp4.12275
Autor:
Ken-ichi Nunoya, Yoshifusa Tobe, Seiji Miyauchi, Takeshi Sawada, Ryuta Asaumi, Kota Toshimoto, Takanori Mori, Yuichi Sugiyam, Yoshitaka Hashimoto, Haruo Imawaka, Keisuke Kakimoto, Yukina Fukuchi, Takeyuki Iwata
Publikováno v:
Journal of Pharmaceutical Sciences. 106:2704-2714
The cause of nonlinear pharmacokinetics (PK) (more than dose-proportional increase in exposure) of a urea derivative under development (compound A: anionic compound [pKa: 4.4]; LogP: 6.5; and plasma protein binding: 99.95%) observed in a clinical tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f920fe1db03e48db8fac1fb5ee78e11
https://doi.org/10.1016/j.xphs.2017.04.052
https://doi.org/10.1016/j.xphs.2017.04.052
Publikováno v:
The Journal of membrane biology. 253(3)
It was reported that nitric oxide (NO) donors increased the permeability of water-soluble compounds across intestinal membrane with neither loss of cell viability nor release of lactate dehydrogenase. Therefore, the detail mechanism of action of NO d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1682fd2953987f1eb2953b8a5345bc
https://pubmed.ncbi.nlm.nih.gov/32328687
https://pubmed.ncbi.nlm.nih.gov/32328687
Autor:
Mikio Tomita, Nasa Sakamoto, Minami Nakagawa, Takahito Furuya, Yusuke Takizawa, Yoshifusa Tobe, Masahiro Hayashi, Hisanao Kishimoto
Publikováno v:
International journal of pharmaceutics. 453(2)
Pharmaceutical excipients should not disturb the effects of drug therapy. In recent years, however, it has been reported that excipients induce some changes to the tight junction (TJ) and P-glycoprotein (P-gp), which can affect drug disposition. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98b62811bace4a44205adb0d7f20940
https://pubmed.ncbi.nlm.nih.gov/23742974
https://pubmed.ncbi.nlm.nih.gov/23742974