Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Yoshifumi MORIKAWA"'
Autor:
Yuji, Sakai, Yoshifumi, Morikawa, Yukino, Nagao, Junta, Hattori, Koichi, Suenami, Emiko, Yanase, Tomohiro, Takayama, Akira, Ikari, Toshiyuki, Matsunaga
Publikováno v:
Neurotoxicity Research. 40:1322-1336
Abuse of pyrrolidinophenone derivatives (PPs) is known to cause severe damage to the central nervous system due to their high lipophilicity. In this study, we compared sensitivity to toxicity elicited by 4'-iodo-α-pyrrolidinononanophenone (I-α-PNP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2984d7840c159c1759a0c5bfbf062c1
https://doi.org/10.1007/s12640-022-00546-y
https://doi.org/10.1007/s12640-022-00546-y
Autor:
Yuji Sakai, Maki Taguchi, Yoshifumi Morikawa, Hidetoshi Miyazono, Koichi Suenami, Yuto Ochiai, Emiko Yanase, Tomohiro Takayama, Akira Ikari, Toshiyuki Matsunaga
Publikováno v:
Toxicology Letters. 355:127-140
In this study, we newly synthesized four α-pyrrolidinononanophenone (α-PNP) derivatives [4'-halogenated derivatives and α-pyrrolidinodecanophenone (α-PDP)], and then performed the structure-cytotoxicity relationship analyses. The results showed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643179ea6afc287c79415cece18d97ac
https://doi.org/10.1016/j.toxlet.2021.11.018
https://doi.org/10.1016/j.toxlet.2021.11.018
Publikováno v:
Chemico-Biological Interactions. 381:110572
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7a05e961de7d0937ed99d2fd36b9a93
https://doi.org/10.1016/j.cbi.2023.110572
https://doi.org/10.1016/j.cbi.2023.110572
Publikováno v:
Mechanical Engineering Journal, Vol 3, Iss 4, Pp 15-00610-15-00610 (2016)
The purpose of this study is to investigate how affect the hot needle punching on bending strength and inter-laminar fracture toughness of CFRTP. Four types of needle in which tip shape were different was used to investigate the effect of needle shap
Externí odkaz:
https://doaj.org/article/2accd9d097a144ff9b032126227e06f7
Autor:
Toshiyuki Matsunaga, Akira Ikari, Yuji Takekoshi, Kiyohito Sato, Koichi Suenami, Yasunari Monguchi, Yuji Sakai, Hidetoshi Miyazono, Yasuhide Sasajima, Yoshifumi Morikawa
Publikováno v:
Forensic Toxicology. 39:123-133
α-Pyrrolidinononanophenone (α-PNP) is a highly lipophilic synthetic cathinone (SC) that possesses a long hydrocarbon chain. It is considered that abuse of α-PNP and its derivatives causes serious health hazards, but there has been little evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f97dd04905dd7ab1b00d9d41f0a08d
https://doi.org/10.1007/s11419-020-00550-x
https://doi.org/10.1007/s11419-020-00550-x
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 221
Most members of the aldo-keto reductase (AKR) 1 C subfamily are hydroxysteroid dehydrogenases (HSDs). Similarly to humans, four genes for AKR1C proteins (AKR1C1-AKR1C4) have been identified in the pig, which is a suitable species for biomedical resea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5b6214b57b6b9be60666eb61f18ebb
https://pubmed.ncbi.nlm.nih.gov/35398259
https://pubmed.ncbi.nlm.nih.gov/35398259
Autor:
Ema Okamoto, Shunsuke Matsuda, Yuta Yoshino, Yoshifumi Morikawa, Koichi Suenami, Yoshiaki Tabuchi, Toshiyuki Matsunaga, Akira Ikari
Publikováno v:
Nutrients; Volume 15; Issue 6; Pages: 1346
The ingested proteins are catabolized to di/tri-peptides and amino acids (AAs), which are absorbed through various transporters in the small intestinal and colonic epithelial cells. Tight junctions (TJs) are formed between neighboring cells and restr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9d7cfb91f9db32979fb70bd5eeb15f
https://doi.org/10.3390/nu15061346
https://doi.org/10.3390/nu15061346
Autor:
Yuji, Sakai, Maki, Taguchi, Yoshifumi, Morikawa, Koichi, Suenami, Emiko, Yanase, Tomohiro, Takayama, Akira, Ikari, Toshiyuki, Matsunaga
Publikováno v:
Chemico-Biological Interactions. 364:110052
Overuse of pyrrolidinophenones (PPs) is known to cause damage to vascular and central nervous systems, but little is known about its effect on brain endothelial barrier function. In this study, we found that exposure to 4'-iodo-α-pyrrolidinononanoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01354fb597d13f9306c764790543bb3
https://doi.org/10.1016/j.cbi.2022.110052
https://doi.org/10.1016/j.cbi.2022.110052
Autor:
Yasuhide Sasajima, Yoshifumi Morikawa, Satoshi Endo, Toshiyuki Matsunaga, Koichi Suenami, Kiyohito Sato, Kyoko Kamase, Hidetoshi Miyazono, Akira Ikari, Yuji Takekoshi, Yasunari Monguchi
Publikováno v:
Neurotoxicity research. 39(4)
Chronic exposure to cathinone derivatives increases the risk of severe health hazards, whereas little is known about the detailed pathogenic mechanisms triggered by the derivatives. We have recently shown that treatment with α-pyrrolidinononanopheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f76b7910d5d039a659da200ea07b8df
https://pubmed.ncbi.nlm.nih.gov/34043181
https://pubmed.ncbi.nlm.nih.gov/34043181
Autor:
Satoshi Endo, Yoshifumi Morikawa, Aki Hisamatsu, Toshiyuki Matsunaga, Naoko Okumura, Koichi Suenami, Akira Ikari, Haruhi Saito
Publikováno v:
Chemico-biological interactions. 332
Irinotecan (CPT11) is widely prescribed for treatment of various intractable cancers such as advanced and metastatic colon cancer cells, but its continuous treatment promotes the resistance development. In this study, we established CPT11-resistant v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118851bb152c122acef4db6740c0618b
https://pubmed.ncbi.nlm.nih.gov/33096057
https://pubmed.ncbi.nlm.nih.gov/33096057