Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Yoshifumi IWAMARU"'
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Bovine spongiform encephalopathy (BSE) is a prion disease in cattle and is classified into the classical type (C-BSE) and two atypical BSEs, designated as high type (H-BSE) and low type (L-BSE). These classifications are based on the electrophoretic
Externí odkaz:
https://doaj.org/article/a1e7414f37b84dfa91c9876efce563c4
Autor:
Kohtaro Miyazawa, Kentaro Masujin, Yuichi Matsuura, Yoshifumi Iwamaru, Takashi Yokoyama, Hiroyuki Okada
Publikováno v:
Veterinary Research, Vol 49, Iss 1, Pp 1-10 (2018)
Abstract In animal prion diseases, including bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease in cervids, and scrapie in sheep and goats, a disease-associated isoform of prion protein (PrPd) accumulates in the brains of affec
Externí odkaz:
https://doaj.org/article/29eced89e3d84436810d0f3a770d8fe4
Autor:
Hiroyuki Okada, Yoshifumi Iwamaru, Morikazu Imamura, Kohtaro Miyazawa, Yuichi Matsuura, Kentaro Masujin, Yuichi Murayama, Takashi Yokoyama
Publikováno v:
Emerging Infectious Diseases, Vol 23, Iss 2, Pp 284-287 (2017)
To determine oral transmissibility of the L-type bovine spongiform encephalopathy (BSE) prion, we orally inoculated 16 calves with brain homogenates of the agent. Only 1 animal, given a high dose, showed signs and died at 88 months. These results sug
Externí odkaz:
https://doaj.org/article/284a77f256944d9f8f77ae84c68c29eb
Autor:
Akikazu Sakudo, Yoshifumi Iwamaru, Koichi Furusaki, Makoto Haritani, Rumiko Onishi, Morikazu Imamura, Takashi Yokoyama, Yasuhiro Yoshikawa, Takashi Onodera
Publikováno v:
Pathogens, Vol 9, Iss 7, p 536 (2020)
Previous studies have revealed that the electrically charged disinfectant CAC-717 has strong virucidal and bactericidal effects but is safe for humans and animals. In this study, CAC-717 was further evaluated for its potential effects as a disinfecta
Externí odkaz:
https://doaj.org/article/7e126c9a5fdb43f7a70f19975fbd5e95
Publikováno v:
Pathogens, Vol 9, Iss 3, p 241 (2020)
The disease-associated prion protein (PrPSc) has the ability to seed the conformational conversion of normal prion proteins into the amyloid fibril form. This prion seeding activity can be measured using an in vitro amplification assay termed real-ti
Externí odkaz:
https://doaj.org/article/e742fc9edf73475aa144051bf6ce3c8c
Autor:
Takashi Yokoyama, Shirou Mohri, Morikazu Imamura, Yoshifumi Iwamaru, Kentaro Masujin, Kazuo Kasai
Publikováno v:
Pathogens, Vol 2, Iss 1, Pp 92-104 (2013)
The pathological prion protein, PrPSc, displays various sizes of aggregates. In this study, we investigated the conformation, aggregation stability and proteinase K (PK)-sensitivity of small and large PrPSc aggregates of mouse-adapted prion strains.
Externí odkaz:
https://doaj.org/article/db744cc4e18f4275b78ecd5480d34a13
Autor:
Yoshifumi Iwamaru, Morikazu Imamura, Yuichi Matsuura, Kentaro Masujin, Yoshihisa Shimizu, Yujing Shu, Megumi Kurachi, Kazuo Kasai, Yuichi Murayama, Shigeo Fukuda, Sadao Onoe, Ken’ichi Hagiwara, Yoshio Yamakawa, Tetsutaro Sata, Shirou Mohri, Hiroyuki Okada, Takashi Yokoyama
Publikováno v:
Emerging Infectious Diseases, Vol 16, Iss 7, Pp 1151-1154 (2010)
We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimental
Externí odkaz:
https://doaj.org/article/15df50730dd9426892ffbe78532a84e2
Autor:
Yuichi Murayama, Miyako Yoshioka, Hiroyuki Okada, Eri Takata, Kentaro Masujin, Yoshifumi Iwamaru, Noriko Shimozaki, Tomoaki Yamamura, Takashi Yokoyama, Shirou Mohri, Yuji Tsutsumi
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144761 (2015)
The global outbreak of bovine spongiform encephalopathy (BSE) has been attributed to the recycling of contaminated meat and bone meals (MBMs) as feed supplements. The use of MBMs has been prohibited in many countries; however, the development of a me
Externí odkaz:
https://doaj.org/article/f6cd10f90506488fa4aa0fd3fc1836b3
Autor:
Morikazu Imamura, Nobuko Kato, Hiroyuki Okada, Miyako Yoshioka, Yoshifumi Iwamaru, Yoshihisa Shimizu, Shirou Mohri, Takashi Yokoyama, Yuichi Murayama
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82538 (2013)
The central event in prion infection is the conformational conversion of host-encoded cellular prion protein (PrP(C)) into the pathogenic isoform (PrP(Sc)). Diverse mammalian species possess the cofactors required for in vitro replication of PrP(Sc)
Externí odkaz:
https://doaj.org/article/e2e69a3b82094fc7afdd30e95c0a96b6
Autor:
Yoshifumi Iwamaru, Takato Takenouchi, Yuichi Murayama, Hiroyuki Okada, Morikazu Imamura, Yoshihisa Shimizu, Makoto Hashimoto, Shirou Mohri, Takashi Yokoyama, Hiroshi Kitani
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37896 (2012)
BACKGROUND: Prion diseases are fatal neurodegenerative disorders with no effective therapy currently available. Accumulating evidence has implicated over-activation of P2X7 ionotropic purinergic receptor (P2X7R) in the progression of neuronal loss in
Externí odkaz:
https://doaj.org/article/013d8b14bb3b4f42a6da8067d4b90f5d