Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Yoshifumi Horisawa"'
1
Impaired Fertility in Female Mice Lacking Urinary Trypsin Inhibitor
Autor: Katsuaki Kato, Norio Nakamura, Hitoshi Niwa, Yoshifumi Horisawa, Chihaya Kakinuma, Nobuhiko Kaga, Shoko Kuroda, Hiroyuki Sato, Satoshi Kajikawa, Hideaki Morishita, Jun-ichi Miyazaki
Publikováno v: Biochemical and Biophysical Research Communications. 281:1154-1160
Urinary trypsin inhibitor (UTI) is a serine proteinase inhibitor that is found in blood and urine. To investigate the physiological functions of UTI in vivo, we generated UTI-deficient mice by gene targeting. The mice showed no obvious abnormalities
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44753af5b820266afcc56c2c746f7e3
https://doi.org/10.1006/bbrc.2001.4475
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2
Design of Variants of the Second Domain of Urinary Trypsin Inhibitor (R-020) with Increased Factor Xa Inhibitory Activity
Autor: Keisuke Sugihara, Hideaki Morishita, Toshinori Kanamori, Hideaki Umeyama, Jiro Hirose, Mitsuko Isaji, Tomokazu Matsusue, Toshihisa Miura, Yoshifumi Horisawa, Toru Yamakawa, Atsushi Nii
Publikováno v: The Journal of Biochemistry. 115:1107-1112
The second domain (R-020) of human urinary trypsin inhibitor (UTI) exerts similar inhibitory activities on trypsin, alpha-chymotrypsin, leukocyte elastase, and plasmin to those of UTI itself, and additionally inhibits coagulation factor Xa (FXa) and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76304e22cde7eebe4e2ec24e77aa8650
https://doi.org/10.1093/oxfordjournals.jbchem.a124465
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3
Chemical Modification of Natural Human Tumor Necrosis Factor-α with Polyethylene Glycol Increases Its Anti-tumor Potency
Autor: Yoshifumi Horisawa, Tadanori Mayumi, Yasuo Tsutsumi, Toshinori Kanamori, Tetsunari Kihira, Shinsaku Nakagawa, Hakuo Ikegami, Masaharu Miyake, Kazuyoshi Kubo, Susumu Yamamoto
Publikováno v: Japanese Journal of Cancer Research : Gann
Natural human tumor necrosis factor-alpha (TNF-alpha) was chemically modified with an active ester of monomethoxy polyethylene glycol (PEG). The molecular weight of PEG-modified TNF-alpha depended on the reaction time as well as the initial molar rat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72dd8ed7afdc7c8b9a2721b0e8c529e
https://doi.org/10.1111/j.1349-7006.1994.tb02879.x
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4
Effect of Human Fibroblast-Derived Interleukin-6 on Platelet Levels in Normal Mice
Autor: Kouichi Noda, Takeshi Kusuyama, Yoshifumi Horisawa, Hiromi Ogino, Tetsuya Asami, Hidemi Ohta, Mitsuko Isaji, Ryo Tanaka
Publikováno v: Japanese Journal of Thrombosis and Hemostasis. 2:461-468
Purified natural human fibroblast-derived interleukin-6 (nhlL-6) was obtained from a culture of a normal human fibroblast cell strain, and its effect on the platelet number in normal mice was examined.The platelet number in female BDF1 mice given sub
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51a1582420ba324003069c5b13e1556e
https://doi.org/10.2491/jjsth.2.461
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5
Molecular design of conjugated tumor necrosis factor-alpha: synthesis and characteristics of polyvinyl pyrrolidone modified tumor necrosis factor-alpha
Autor: Yoshifumi Horisawa, Shinsaku Nakagawa, Yoshihisa Kaneda, Tetsunari Kihira, Yasuo Tsutsumi, Shin-ichi Tsunoda, Yoko Yamamoto, Tadanori Mayumi, Haruhiko Kamada
Publikováno v: Biochemical and biophysical research communications. 257(2)
We conjugated tumor necrosis factor-alpha (TNF-alpha) with the synthetic polymeric modifier polyvinyl pyrrolidone (PVP) to facilitate its clinical use for anti-tumor therapy. TNF-alpha was chemically conjugated with the terminal carboxyl-bearing PVP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ea84b53af8bac817cf2cb91c75e34c
https://pubmed.ncbi.nlm.nih.gov/10198233
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6
Oral-mucosal administration of IFN-alpha potentiates immune response in mice
Autor: Kazuya Yamashiro, Noriko Hara, Yuji Nagao, Akio Uemura, Yoshifumi Horisawa, Katsuaki Kato
Publikováno v: Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 18(9)
We studied the effects of oral-mucosal administration of murine interferon-alpha (Mu-IFN-alpha) on immune responses and infection with vaccinia virus (VV) in mice. When Mu-IFN-alpha was administered to sheep red blood cell (SRBC)-sensitized mice for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade9de3c5ae49afdf393f5c7696e1871
https://pubmed.ncbi.nlm.nih.gov/9781804
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7
In vivo anti-tumor efficacy of polyethylene glycol-modified tumor necrosis factor-alpha against tumor necrosis factor-resistant tumors
Autor: Tetsunari Kihira, Haruhiko Kamada, Yasuo Tsutsumi, Yoshihisa Kaneda, Yoko Yamamoto, Yoshifumi Horisawa, Tadanori Mayumi, Shin-ichi Tsunoda, Shinsaku Nakagawa
Publikováno v: Japanese Journal of Cancer Research : Gann
We previously reported that the optimally PEGylated tumor necrosis factor-alpha (MPEG-TNF-alpha), in which 56% of the TNF-alpha-lysine amino groups were coupled with polyethylene glycol (PEG), had about 100-fold greater anti-tumor effect than native
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b1eb8e5ca1b48435af13e7f9a71f39
https://pubmed.ncbi.nlm.nih.gov/8957067
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8
In vivoAntitumor Mechanism of Natural Human Tumor Necrosis Factor Involving a T Cell-mediated Immunological Route
Autor: Yoshifumi Horisawa, Masahiro Nobuhara, Kazuharu Kato, Masashi Kurimoto, Meroni Imai, Yasuo Tanaka, Norio Nakamura, Tetsuya Asami, Yoshitaka Hosaka, Toshinori Kanamori, Yoshikazu Ashida
Publikováno v: Japanese Journal of Cancer Research : Gann
We have investigated the in vivo antitumor mechanism of natural human tumor necrosis factor (n‐TNF) isolated from a culture of human leukemic B cell line (BALL‐1), especially its action as an immunomodulator, and found that the in vivo antitumor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a89e12999371affc84a6c853c3540d
https://doi.org/10.1111/j.1349-7006.1989.tb01648.x
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10
Combined effects of urinary plasminogen activator and tissue-type plasminogen activator in vitro and in vivo models
Autor: Kazuharu Katoh, Yasuhiro Harada, Masahiro Nobuhara, Yoshifumi Horisawa, Yoshikazu Ashida
Publikováno v: Blood & Vessel. 18:464-470
The in vitro and in vivo combined effects of urinary plasminogen activator (u-PA) and tissue plasminogen activator (t-PA) were examined. In in vitro experiments the additive combined effects of u-PA and t-PA were observed on human plasma clot lysis.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f514254e1d96a922356f914f146e4ff
https://doi.org/10.2491/jjsth1970.18.464
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