Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Yoshie Umemura"'
Autor:
Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph J. Dresser, Christian K. Werner, Hanshi Sun, Drew Pratt, Peter Sajjakulnukit, Shuang G. Zhao, Mary Davis, Barbara S. Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, Yoshie Umemura, Angela K. Walker, Maureen Kachman, Jann N. Sarkaria, Jianping Xiong, Meredith A. Morgan, Alnawaz Rehemtualla, Maria G. Castro, Pedro Lowenstein, Sriram Chandrasekaran, Theodore S. Lawrence, Costas A. Lyssiotis, Daniel R. Wahl
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcom
Externí odkaz:
https://doaj.org/article/1b59daa1bcd04cf3a9e4d552dbc954ba
Autor:
Andrea Comba, Syed M. Faisal, Maria Luisa Varela, Todd Hollon, Wajd N. Al-Holou, Yoshie Umemura, Felipe J. Nunez, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Glioblastomas (GBM) are the most common and aggressive tumors of the central nervous system. Rapid tumor growth and diffuse infiltration into healthy brain tissue, along with high intratumoral heterogeneity, challenge therapeutic efficacy and prognos
Externí odkaz:
https://doaj.org/article/b7e691d8bc6c44449e5536f4139959a2
Autor:
Yoshie Umemura, Baber Khan, Benjamin J. Weill, Justin J. Buthorn, Anna Skakodub, Andrew J. Ridder, Kathryn S. Nevel, Yilun Sun, Adrienne Boire
Publikováno v:
Neurol Clin Pract
Background and ObjectivesNovel diagnostic techniques and neurologic biomarkers have greatly expanded clinical indications for CSF studies. CSF is most commonly obtained via lumbar puncture (LP). Although it is generally believed that LPs are well tol
Autor:
Anna M Laucis, Katherine Selwa, Yilun Sun, Michelle M Kim, Kyle C Cuneo, Theodore S Lawrence, Daniel R Wahl, Larry Junck, Yoshie Umemura
Publikováno v:
Neurooncol Pract
Background There is no consensus on the treatment of central nervous system (CNS) lymphoma refractory to first-line methotrexate-based chemotherapy. Whole brain radiotherapy (WBRT) is sometimes used but may result in unacceptable neurocognitive dysfu
Autor:
Andrew J. Scott, Luis O. Correa, Donna M. Edwards, Yilun Sun, Visweswaran Ravikumar, Anthony C. Andren, Li Zhang, Sudharsan Srinivasan, Neil Jairath, Kait Verbal, Karin Muraszko, Oren Sagher, Shannon A. Carty, Shawn Hervey-Jumper, Daniel Orringer, Michelle M. Kim, Larry Junck, Yoshie Umemura, Denise Leung, Sriram Venneti, Sandra Camelo-Piragua, Theodore S. Lawrence, Joseph E. Ippolito, Wajd N. Al-Holou, Prakash Chinnaiyan, Jason Heth, Arvind Rao, Costas A. Lyssiotis, Daniel R. Wahl
Publikováno v:
Antioxidants & Redox Signaling.
Autor:
Weihua Zhou, Zitong Zhao, Angelica Lin, John Yang, Jie Xu, Wilder-Romans Kari, Annabel Yang, Jing Li, Sumeet Solanki, Jennifer Speth, Natalie Walker, Andrew J. Scott, Ayesha U. Kothari, Yangyang Yao, Erik R. Peterson, Navyateja Korimerla, Christian K. Werner, Jessica Liang, Janna Jacobson, Sravya Palavalasa, Alexandra M. Obrien, Ameer L. Elaimy, Sean P. Ferris, Shuang G. Zhao, Jann N. Sarkaria, Balázs Győrffy, Shuqun Zhang, Wajd N Al-Holou, Yoshie Umemura, Meredith A. Morgan, Theodore S. Lawrence, Costas A. Lyssiotis, Marc Peters-Golden, Yatrik M. Shah, Daniel R. Wahl
Publikováno v:
bioRxiv
How cell metabolism regulates DNA repair is incompletely understood. Here, we define a GTP-mediated signaling cascade that links metabolism to DNA repair and has significant therapeutic implications. GTP, but not other nucleotides, regulates the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47dac35ff3bc7bc06b90f06a038189a
https://europepmc.org/articles/PMC10120670/
https://europepmc.org/articles/PMC10120670/
Autor:
Yoshie Umemura, Daniel Orringer, Larry Junck, Jason Heth, Oren Sagher, Denise Leung, Aaron Mammoser, Shawn Hervey-Jumper, Maria L. Varela, Andrea Comba, Syed M. Faisal, Daniel Zamler, Viveka N. Yadav, Patrick Dunn, Molly E.J. West, Wajd Al-Holou, Todd Hollon, Michelle M. Kim, Daniel R. Wahl, Sandra Camelo-Piragua, Andrew P. Lieberman, Sriram Venneti, Paul McKeever, Theodore Lawrence, Ryo Kurokawa, Kait Verbal, Karen Sagher, David Altshuler, Lili Zhao, Karin Muraszko, Maria G. Castro, Pedro R. Lowenstein
BACKGROUNDHigh-grade gliomas are fatal with universally poor prognosis. Initiation of effective cancer immune responses requires functional immune cells, especially afferent antigen presenting cells, which are absent from the brain parenchyma.1, 2To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8d6bdb04ddf1db589728a6eb30d70c
https://doi.org/10.1101/2022.11.04.22281950
https://doi.org/10.1101/2022.11.04.22281950
Autor:
Jason Heth, Yue Cao, B.S. Rosen, James M. Balter, Michelle M. Kim, Wajd N. Al-Holou, Daekeun You, Matthew J. Schipper, Daniel R. Wahl, Theodore S. Lawrence, Morand Piert, Yoshie Umemura, Emily M. Briceño, Denise Leung, Charles S. Mayo, Hemant Parmar, Nicolette Gabel, Yilun Sun, Larry Junck, Madhava P. Aryal
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 110:792-803
Purpose We hypothesized that dose-intensified chemoradiation therapy targeting adversely prognostic hypercellular (TVHCV) and hyperperfused (TVCBV) tumor volumes would improve outcomes in patients with glioblastoma. Methods and Materials This single-
Autor:
Abed Rahman Kawakibi, Rohinton Tarapore, Sharon Gardner, Andrew Chi, Sylvia Kurz, Patrick Y Wen, Isabel Arrillaga-Romany, Tracy Batchelor, Nicholas Butowski, Ashley Sumrall, Nicole Shonka, Rebecca Harrison, John DeGroot, Minesh Mehta, Yazmin Odia, Matthew Hall, Doured Daghistani, Timothy Cloughesy, Benjamin Ellingson, Michelle Kim, Yoshie Umemura, Hugh Garton, Andrea Franson, Jonathan Schwartz, Sunjong Li, Rodrigo Cartaxo, Karthik Ravi, Evan Cantor, Jessica Cummings, Alyssa Paul, Dustin Walling, Matthew Dun, Jason Cain, Jiang Li, Mariella Filbin, Lili Zhao, Chandan Kumar-Sinha, Rajen Mody, Arul Chinnaiyan, Ryo Kurokawa, Drew Pratt, Sriram Venneti, Jacques Grill, Cassie Kline, Sabine Mueller, Adam C Resnick, Javad Nazarian, Sebastian Waszak, Joshua E Allen, Carl Koschmann
Publikováno v:
Neuro-Oncology. 24:vii86-vii87
Patients with H3K27M-mutated diffuse midline glioma (DMG) have no proven effective therapies beyond radiation. ONC201, a DRD2 antagonist and mitochondrial ClpP agonist, has shown promise in this population. Clinical and genetic variables associated w