Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Yoshie Masaoka"'
Autor:
Haruki Higashino, Makoto Kataoka, Naoki Morimoto, Hironori Kumagai, John C. Gore, Etsuo Tobita, Seiji Koike, Wellington Pham, Shinji Yamashita, Shinji Sakuma, Ken-ichiro Hiwatari, Moe Shimosato, Yoshie Masaoka, Tokio Kitamura, Robert M. Hoffman
Publikováno v:
Contrast Media & Molecular Imaging. 10:135-143
We have been investigating an imaging agent that enables real-time and accurate diagnosis of early colorectal cancer at the intestinal mucosa by colonoscopy. The imaging agent is peanut agglutinin-immobilized polystyrene nanospheres with surface poly
Autor:
Rie Matsui, Makoto Kataoka, Shinji Sakuma, Haruki Higashino, Shinji Yamashita, Tsubasa Hasegawa, Yoshie Masaoka, Mari Yamamoto
Publikováno v:
Molecular Pharmaceutics. 11:746-754
The aim of this study was to establish an in vitro method for evaluating the effect of supersaturation on oral absorption of poorly water-soluble drugs in vivo. Albendazole, dipyridamole, gefitinib, and ketoconazole were used as model drugs. Supersat
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 85:1317-1324
This study aims to assess the absorption potential of oral absorption of poorly water-soluble drugs by using the dissolution/permeation system (D/P system). The D/P system can be used to perform analysis of drug permeation under dissolution process a
Autor:
Makoto Kataoka, Shinji Yamashita, Kohsaku Kawakami, Shaoling Zhang, Marina Yamamoto, Rohit Singh Chauhan, Narimoto Ishizuka, Shinji Sakuma, Yoshie Masaoka
Publikováno v:
International Journal of Pharmaceutics. 450:123-128
A coaxial electrospray technique was applied to a poorly soluble drug, fenofibrate (FEN), to increase its bioavailability. A particulate core-shell solid dispersion was designed using poly(methacrylic acid-co-methyl methacrylate) (Eudragit L-100) as
Autor:
Noriko Nakajima, Ryoji Kimura, Hitoshi Yamauchi, Yoshie Masaoka, Masaya Suita, Yoko Marui, Hiroyuki Tachikawa, Norihiro Shinkai, Shinji Yamashita, Kazuhiro Nishida, Makoto Kataoka, Masanori Baba, Saki Inoue, Shinji Sakuma, Tomofumi Uto, Ken-ichiro Hiwatari
Publikováno v:
Molecular Pharmaceutics. 9:2933-2941
We evaluated the potential of poly(N-vinylacetamide-co-acrylic acid) modified with d-octaarginine, which is a typical cell-penetrating peptide, as a carrier for mucosal vaccine delivery. Mice were nasally inoculated four times every seventh day with
Autor:
Kelly Lane Jones, Jing Wen Wong, Claudia da Costa Mathews, Shinji Yamashita, Yoshie Masaoka, Kiyohiko Sugano, Makoto Kataoka, Shinji Sakuma
Publikováno v:
Pharmaceutical Research. 29:1485-1494
The aim of the present study is to evaluate the formulation effect on the oral absorption of poorly water-soluble drugs using a dissolution/permeation system (D/P system). This D/P system, consisting of apical and basal chambers and a Caco-2 cell mon
Publikováno v:
European Journal of Pharmaceutical Sciences. 44:544-551
The purpose of this study was to establish an in vitro system that evaluates the effects of P-glycoprotein (P-gp)-mediated efflux on the oral absorption of P-gp substrates. An in vitro system (dissolution/permeation system, D/P system) was developed
Autor:
Makoto Kataoka, Shinji Sakuma, Shinji Yamashita, Katsuaki Iwai, Yoshie Masaoka, Toshiyasu Sakane
Publikováno v:
International Journal of Pharmaceutics. 414:69-76
The aim of this study is to establish a theoretical method for the prediction of human intestinal permeability from in vitro permeation assay. Pore radius and porosity/length and ion selectivity of the paracellular pathway were calculated using the R
Autor:
Shinji Sakuma, Shinji Yamashita, Marina Yamamoto, Kohsaku Kawakami, Yoshie Masaoka, Makoto Kataoka, Shaoling Zhang
Publikováno v:
Molecular Pharmaceutics. 8:807-813
Development of oral dosage forms containing poorly water-soluble drugs is a major challenge in the pharmaceutical industry. This paper describes the use of coaxial electrospray deposition as a promising formulation technology for oral delivery of poo
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:401-407
The aim of the present work was to confirm the usefulness of the dissolution/permeation system (D/P system) in the estimation of human oral absorption of poorly water-soluble drugs. The D/P system, which can simultaneously evaluate drug absorption pr