Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yoshiari Shimmyo"'
Autor:
Ryoko Kuwayama, Keiichiro Suzuki, Jun Nakamura, Emi Aizawa, Yoshichika Yoshioka, Masahito Ikawa, Shin Nabatame, Ken-ichi Inoue, Yoshiari Shimmyo, Keiichi Ozono, Taroh Kinoshita, Yoshiko Murakami
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Inherited GPI deficiency (IGD) is caused by PIGO mutations. Here, the authors generate a mouse model of IGD and show that AAV-mediate gene therapy, for knock-in as well as extra-chromosomal expression of Pigo cDNA, ameliorates pathology in the mice.
Externí odkaz:
https://doaj.org/article/279353779621470d85a9bf09f282cfcc
Autor:
Shiro Imagama, Ryoko Ogino, Shinya Ueno, Norihito Murayama, Naohiro Takemoto, Yoshiari Shimmyo, Taisuke Kadoshima, Shigeki Tamura, Mariko Kuroda, Yukihiro Matsuyama, Kenji Kadomatsu, Yasuhiro Morita, Teruyoshi Inoue, Naoki Ishiguro
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236050 (2020)
Neurotrophic factors have been regarded having promising potentials for neuronal protection and regeneration, and thus promoting beneficial effects of kinesiological functions. They can be suspected to play important roles in cell/tissue grafting for
Externí odkaz:
https://doaj.org/article/b9a2abefb34d4602b1df52f9a28574d4
Autor:
Nobuhiro Narii, Yoshiari Shimmyo, Kenji Murata, Tetsuya Toba, Hidekazu Inoue, Takahiro Matsumoto, Hiroki Sakai, Naohiro Takemoto, Yoshiyuki Igawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2332-2337
To avoid production of a phospholipidosis-inducing metabolite, we replaced the amide structure of SUN13837 (1) with a 1,2,3-triazole. The resulting 1,2,3-triazole analog of 1 (compound 2) displayed greater neuroprotective activity than 1. Structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baee5e1f6c21724d69605ac50218b352
https://doi.org/10.1016/j.bmcl.2019.06.016
https://doi.org/10.1016/j.bmcl.2019.06.016
Autor:
Ryoko Kuwayama, Keiichiro Suzuki, Jun Nakamura, Emi Aizawa, Yoshichika Yoshioka, Masahito Ikawa, Shin Nabatame, Ken-ichi Inoue, Yoshiari Shimmyo, Keiichi Ozono, Taroh Kinoshita, Yoshiko Murakami
Publikováno v:
Nature communications. 13(1)
Inherited glycosylphosphatidylinositol (GPI) deficiency (IGD) is caused by mutations in GPI biosynthesis genes. The mechanisms of its systemic, especially neurological, symptoms are not clarified and fundamental therapy has not been established. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c519f7bff1cdbed160c3fe850877f536
https://pubmed.ncbi.nlm.nih.gov/35661110
https://pubmed.ncbi.nlm.nih.gov/35661110
Autor:
Yoshiari Shimmyo, Naohiro Takemoto, Yoshiyuki Igawa, Shinya Ueno, Nobuhiro Narii, Kenji Murata, Tetsuya Toba, Hidekazu Inoue, Hiroki Sakai
Publikováno v:
Bioorganicmedicinal chemistry. 28(14)
SUN13837 (1), a fibroblast growth factor receptor modulator, has been an attractive candidate for treating neurodegenerative diseases. However, one of its metabolites, N-benzyl-4-(methylamino)piperidine (BMP), turned out to possess phospholipidosis-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b7a19f61b8950e9f00b9775a622d5b
https://pubmed.ncbi.nlm.nih.gov/32616184
https://pubmed.ncbi.nlm.nih.gov/32616184
Autor:
Yoshiari Shimmyo, Yoshito Kawamoto, Kazumichi Goto, Mariko Kuroda, Tsuyoshi Muto, Hirokazu Annoura, Ryosuke Suzuki, Junko Futamura-Takahashi, Michinori Kadokura, Shigeki Nara-shi Tamura, Tetsuya Toba, Teruyoshi Inoue
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2528-2532
A series of compounds was discovered that induce the production of VGF mRNA in SH-SY5Y cells and exhibit cytoprotection under tunicamycin induced endoplasmic reticulum (ER) stress. The aminophenol ring and linker chain of the template SUN N8075 (1) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58608419515f8c35d3a31c8332c0e5b9
https://doi.org/10.1016/j.bmcl.2018.05.047
https://doi.org/10.1016/j.bmcl.2018.05.047
Autor:
Norihito Murayama, Naoki Ishiguro, Naohiro Takemoto, Kenji Kadomatsu, Shigeki Nara-shi Tamura, Taisuke Kadoshima, Yoshiari Shimmyo, Shinya Ueno, Yasuhiro Morita, Teruyoshi Inoue, Ryoko Ogino, Shiro Imagama, Yukihiro Matsuyama, Mariko Kuroda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0236050 (2020)
PLoS ONE, Vol 15, Iss 7, p e0236050 (2020)
Neurotrophic factors have been regarded having promising potentials for neuronal protection and regeneration, and thus promoting beneficial effects of kinesiological functions. They can be suspected to play important roles in cell/tissue grafting for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d658c31b2d49203be77bcb430de3647f
https://doi.org/10.1371/journal.pone.0236050
https://doi.org/10.1371/journal.pone.0236050
Autor:
Yoshiari Shimmyo, Takeshi Kihara, Tetsuhiro Niidome, Huilian Shen, Hachiro Sugimoto, Keiko Yazawa
Publikováno v:
FEBS Letters. 580:6623-6628
Glutamate excitotoxicity is mediated by intracellular Ca(2+) overload, caspase-3 activation, and ROS generation. Here, we show that curcumin, tannic acid (TA) and (+)-catechin hydrate (CA) all inhibited glutamate-induced excitotoxicity. Curcumin inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff13825a93e3b58973a6dd31070cfc6
https://doi.org/10.1016/j.febslet.2006.11.011
https://doi.org/10.1016/j.febslet.2006.11.011
Autor:
Miyo Sakai, T. Nakamura, Yutaka Sadakane, Yuji Goto, Yoshiari Shimmyo, Kirsten J. Lampi, Tadatoshi Kinouchi, Noriko Fujii, Yukio Morimoto
Publikováno v:
Amino Acids. 32:87-94
Lens alpha-crystallin, composed of two subunits alpha A- and alpha B-crystallin, forms large aggregates in the lens of the eye. The present study investigated the aggregate of human lens alpha-crystallin from elderly and young donors. Recombinant alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fb0e191c4d654716089ab2e1672780
https://doi.org/10.1007/s00726-006-0303-4
https://doi.org/10.1007/s00726-006-0303-4
Autor:
Taisuke Kadoshima, Yoshiari Shimmyo, Mariko Kuroda, Ryoko Ogino, Tetsuya Toba, Norihito Murayama, Shiho Kodama, Naohiro Takemoto, Teruyoshi Inoue, Shinya Ueno, Takafumi Noshita, Tetsushi Oka, Yasuhiro Morita
Basic fibroblast growth factor (bFGF) offers some measure of protection against excitotoxic neuronal injuries by upregulating the expression of the calcium-binding protein calbindin-D28k (Calb). The newly synthesized small molecule 4-({4-[[(4-amino-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e3a249b9bf7dad203e2be0ff50e9cc
https://europepmc.org/articles/PMC3582292/
https://europepmc.org/articles/PMC3582292/
