Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Yoshiaki Yanai"'
Autor:
Ken-Ichiro Yoshida, Yoshiaki Yanai, Toyonori Tsuzuki, Kyoko Arai, Takao Kamai, Hideyuki Abe, Akinori Nukui
Publikováno v:
Oncotarget
Renal cell carcinoma (RCC) is an immunogenic tumor that shows a metabolic shift to aerobic glycolysis. The immune system can have opposing host-protective and tumor-promoting effects, and aerobic glycolysis suppresses antitumor immunity. In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc22fe529dde2210ed0c27bd29579c1
https://doi.org/10.18632/oncotarget.23683
https://doi.org/10.18632/oncotarget.23683
Autor:
Yoshiaki Yanai, Yuko Sekine, Masashi Kurimoto, Yasuhiro Itsui, Naoya Sakamoto, Shinya Maekawa, Sei Kakinuma, Tomoyuki Koyama, Mamoru Watanabe, Mina Nakagawa, Yoko Tanabe, Yoshie Takeda
Publikováno v:
Hepatology Research. 34:41-49
Backgrounds Interferon (IFN)-alpha is represented by several structurally related subtypes that show different antiviral and anti-tumor effects. Here, we analyzed differential effects of IFN-alpha subtypes on intracellular hepatitis C virus (HCV) rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10fcac6de41459456864386dd51d875
https://doi.org/10.1016/j.hepres.2005.10.005
https://doi.org/10.1016/j.hepres.2005.10.005
Autor:
Takeshi Tanaka, Masashi Kurimoto, Masao Ikeda, Hakuo Ikegami, Hiroshi Yamauchi, Yoshiaki Yanai, Shigeto Yamamoto, Noboru Fujioka, Toshio Ariyasu, Kunzo Orita
Publikováno v:
Biomedical Research. 25:75-82
Enhanced T helper 1 (Th1)-type immunity was observed in patients with hepatitis C virus (HCV) infection during investigations on the efficiency of interferon (IFN) therapy. The mechanism for the shift to Th1-type immunity is, however, obscure in HCV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22d8eef58478d4e806e59bc4dbf833f2
https://doi.org/10.2220/biomedres.25.75
https://doi.org/10.2220/biomedres.25.75
Autor:
Toshio Ariyasu, Noboru Fujioka, Hakuo Ikegami, Hiroshi Yamauchi, Masashi Kurimoto, Shigeto Yamamoto, Takeshi Tanaka, Yoshiaki Yanai, Masao Ikeda
Publikováno v:
Biomedical Research. 24:231-237
T helper (Th) cells have been characterized into two subsets, Th1 and Th2, by the pattern of cytokine secretion. Generally, Th1 type cells mediate cellular immune responses and Th2 type cells mediate humoral immunity. Recently, Thl type immunity is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f0d7ba7e936ab159d81814f3b42327c
https://doi.org/10.2220/biomedres.24.231
https://doi.org/10.2220/biomedres.24.231
Autor:
Osamu Sanou, Kouzou Yamamoto, Masashi Kurimoto, Yoshiaki Yanai, Hiroshi Yamauchi, Hakuo Ikegami
Publikováno v:
Cancer Letters. 185:173-179
Here we report on the anti-tumor effects of five interferon (IFN)-alpha subtypes, alpha1, alpha2, alpha5, alpha8, and alpha10 in chronic myelogenous leukaemia (CML)-derived cell lines. All of the CML cells can respond to IFN-alpha although the anti-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f488feb107890debae71972462e1297e
https://doi.org/10.1016/s0304-3835(02)00277-x
https://doi.org/10.1016/s0304-3835(02)00277-x
Autor:
Kouzou Yamamoto, Tadaichi Kitamura, Hakuo Ikegami, Hiroshi Yamauchi, Masashi Kurimoto, Shigeo Horie, Yoshiaki Yanai
Publikováno v:
Journal of Interferon & Cytokine Research. 21:1129-1136
Interferon-alpha (IFN-alpha) has a number of therapeutic applications in the treatment of various human cancers and diseases of viral origin. IFN-alpha includes several subtypes, and little has been reported on the biologic properties of the individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1366b65510317a81db3a203ea6994999
https://doi.org/10.1089/107999001317205268
https://doi.org/10.1089/107999001317205268
Autor:
Hirotada Kojima, Yasushi Aizawa, Yoshiaki Yanai, Katsue Nagaoka, Makoto Takeuchi, Tsunetaka Ohta, Hakuo Ikegami, Masao Ikeda, Masashi Kurimoto
Publikováno v:
The Journal of Immunology. 162:5063-5069
IL-18 is a multifunctional cytokine playing various regulatory roles in the immune system including induced cytokine production. As a part of our ongoing studies on the molecular mechanisms of IL-18-induced IFN-γ production, we have examined the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2b6668e7974154252b30bc49a080087
https://doi.org/10.4049/jimmunol.162.9.5063
https://doi.org/10.4049/jimmunol.162.9.5063
Autor:
Yoshiaki Yanai, Hajime Ohigashi, Paul A. Wender, Akifumi Nakahara, and Hiroaki Konishi, Hiroyuki Fukuda, Ushio Kikkawa, Kazuhiro Irie, Kentaro Oie
Publikováno v:
Journal of the American Chemical Society. 120:9159-9167
The protein kinase C (PKC) family of enzymes plays a crucial role in cellular signal transduction and tumor promotion. Conventional and novel PKC isozymes consist of a catalytic domain for protein ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df924f40af11b98b047859b576b5b433
https://doi.org/10.1021/ja981087f
https://doi.org/10.1021/ja981087f
Autor:
Yoshiaki Yanai, Masashi Kurimoto, Hiroshi Yokoyama, Nobutaka Ohta, Tadaichi Kitamura, Satoru Takahashi
Publikováno v:
International Journal of Urology. 13:282-284
Interferon-related severe adverse events on the central nervous system are relatively rare, because interferon-alpha (INF-alpha) can not cross an intact blood-brain barrier. We experienced remarkable mental deterioration caused by INF-alpha administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de90109cdac816c32c29aead11b61c0
https://doi.org/10.1111/j.1442-2042.2006.01284.x
https://doi.org/10.1111/j.1442-2042.2006.01284.x
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:965-970
The effects of zine and other metal ions on the folding and phorbol ester-binding of protein kinase C (PKC) surrogates have been investigated using the second cysteine-rich domain model peptides of rat PKCγ and mouse PKCη (γ-CRD2 and η-CRD2). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f11632af333464e1f25eea11390084ac
https://doi.org/10.1016/s0960-894x(97)00140-6
https://doi.org/10.1016/s0960-894x(97)00140-6