Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Yoshiaki Okamiya"'
1
Effect of palonidipine hydrochloride (TC-81), a novel calcium antagonist, on the canine coronary artery
Autor: Kumiko Aoki, Toru Takeshita, Kenji Hoshina, Kiyotaka Sunakawa, Yoshiaki Okamiya, Tadashi Kishimoto
Publikováno v: Folia Pharmacologica Japonica. 102:23-33
The effects of palonidipine hydrochloride [TC-81: (+/-)-3-benzylmethylamino)-2,2-dimethylpropyl methyl 4-(2-fluoro-5-nitrophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate hydrochloride], a new calcium antagonist, on the coronary artery were
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946ece7c2c193c39c39126a147e85214
https://doi.org/10.1254/fpj.102.23
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2
Inhibitory effects of palonidipine hydrochloride (TC-81) on contractions induced by various vasoconstrictors in rat aorta
Autor: Tadashi Kishimoto, Yoshiaki Okamiya, Kenji Hoshina, Toru Takeshita, Kiyotaka Sunakawa, Kumiko Aoki
Publikováno v: Folia Pharmacologica Japonica. 101:281-288
Inhibitions by palonidipine hydrochloride (TC-81), a new Ca entry blocker, of the contractile responses to norepinephrine (NE), serotonin (5-HT), prostaglandin F2 alpha (PGF2 alpha) and U-46619, a thromboxane A2 analog, were investigated in isolated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575d1c20fa69b308631a8f14b21da9a3
https://doi.org/10.1254/fpj.101.4_281
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4
The preclinical safety evaluation of human monoclonal antibody against cytomegalovirus*1
Autor: Satoshi Asano, Satoshi Sasaki, Takami Tomiyama, Sunao Ikegawa, Tamotsu Koyama, Keiko Matsuzawa, Shigeki Sugawara, Kyoko Inoue, Yoshinori Kasahara, Yoshiaki Okamiya, Tomohiro Ohta, Tokutaro Makita
Publikováno v: Fundamental and Applied Toxicology. 19:26-32
The human monoclonal antibody against cytomegalovirus (Mab C23) was examined pharmacokinetically and toxicologically as part of the preclinical studies prior to approval for human use. Rats given repeated intravenous administrations of Mab C23 produc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::996c68bd864603019a19cbd28698e721
https://doi.org/10.1016/0272-0590(92)90024-c
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5
Synthesis and Antihypertensive Activity of 1,4-Dihydropyridine Derivatives with a 4-(Disubstituted Phenyl) Ring and an Aminoalyl Ester Group: Highly Potent and Long-Lasting Calcium Antagonists
Autor: Yoshiaki Okamiya, Hideo Kanno, Tatsuyuki Naruchi, Kiyotaka Sunakawa, Hisao Yamaguchi, Toru Takeshita
Publikováno v: Chemical and Pharmaceutical Bulletin. 40:2049-2054
New 1, 4-dihydropyridine derivatives bearing a 4-(disubstituted phenyl) ring and an aminoethyl ester or an amino-2, 2-dimethylpropyl ester were synthesized and their antihypertensive activities were examined in normotensive rats and spontaneously hyp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963a6ebb487788e8c69b72533d324e4e
https://doi.org/10.1248/cpb.40.2049
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7
Effect of TC-81, a new dihydropyridine derivative, on K+-induced contraction in rat aorta
Autor: Toru Takeshita, Tadashi Kishimoto, H Tanabe, Yoshiaki Okamiya, T Naruchi, Kumiko Aoki
Publikováno v: European Journal of Pharmacology. 205:49-54
TC-81 (3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl methyl-2,6-dimethyl-4-(2-fluoro-5-nitrophenyl)-1,4-dihydro-pyridine- 3,5-dicarboxylate hydrochloride) is a new dihydropyridine derivative. The effects of TC-81 (10(-10)-10(-8) M) on high K(+)-induc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c06b01537d0b971934fdc84022f817d
https://doi.org/10.1016/0014-2999(91)90769-m
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8
[Effect of palonidipine hydrochloride (TC-81), a new dihydropyridine derivative, on various myocardial ischemic models]
Autor: Mikio Ota, Yoshiaki Okamiya, Kenji Hoshina, Kumiko Aoki, Toru Takeshita, Tadashi Kishimoto
Publikováno v: Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 102(2)
The antianginal effects of palonidipine, a novel 1,4-dihydropyridine derivative, and nifedipine on various myocardial ischemic models were compared. (1) Palonidipine at 0.5 mg/kg, p.o. significantly inhibited vasopressin-induced ST depression of ECG
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf5f9879e915184d4e9194092fd1cfd
https://pubmed.ncbi.nlm.nih.gov/8370558
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9
Differences in responses to TC-81 among various arteries in dogs
Autor: Kiyotaka Sunakawa, Kumiko Aoki, Tadashi Kishimoto, Yoshiaki Okamiya, Toru Takeshita
Publikováno v: Journal of cardiovascular pharmacology. 20(6)
The vasodilation induced by TC-81 was investigated in vitro and in vivo. In helical strips of dog arteries precontracted with 65.4 mM KCl, TC-81, nicardipine, nifedipine, diltiazem, and papaverine produced concentration-dependent relaxation. The pote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94648539ac5f6d5105a26093986d37c
https://pubmed.ncbi.nlm.nih.gov/1282595
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10
Relationship between tissue content of TC-81 and relaxation of rat aorta
Autor: Tadashi Kishimoto, Toru Takeshita, Hirohumi Tanabe, Kumiko Aoki, Yoshiaki Okamiya
Publikováno v: European journal of pharmacology. 222(1)
This study dealt with the relationship between the relaxant action of TC-81, a new Ca2+ antagonist, and its distribution in rat aorta depolarized by high K+ (65.4 mM). The inhibitory effect by TC-81 on K(+)-induced contraction and 45Ca2+ uptake was s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69234abe689426524079ca2fe135bf21
https://pubmed.ncbi.nlm.nih.gov/1468502
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