Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Yoshiaki Nabuchi"'
Autor:
Hikaru Koga, Takashi Yamano, Juan Betancur, Satoko Nagatomo, Yousuke Ikeda, Kazuki Yamaguchi, Yoshiaki Nabuchi, Kazuki Sato, Yuri Teranishi-Ikawa, Motohiko Sato, Hiroyuki Hirayama, Akira Hayasaka, Takuya Torizawa, Kenta Haraya, Zenjiro Sampei, Hirotake Shiraiwa, Takehisa Kitazawa, Tomoyuki Igawa, Taichi Kuramochi
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTEfficient production of bispecific antibodies (BsAbs) in single mammalian cells is essential for basic research and industrial manufacturing. However, preventing unwanted pairing of heavy chains (HCs) and light chains (LCs) is a challenging t
Externí odkaz:
https://doaj.org/article/281415e66ed346d99393535f365215ff
Autor:
Hikaru Koga, Haruka Kuroi, Rena Hirano, Hiroyuki Hirayama, Yoshiaki Nabuchi, Taichi Kuramochi
Publikováno v:
Antibodies, Vol 13, Iss 1, p 3 (2024)
Bispecific antibodies (BsAbs) can bind to two different antigens, enabling therapeutic concepts that cannot be achieved with monoclonal antibodies. Immuno-competent mice are essential for validating drug discovery concepts, necessitating the developm
Externí odkaz:
https://doaj.org/article/d47409dab8fa4db6a499b211dfb96e7f
Autor:
Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda, Yukiko Okuyama-Nishida, Chifumi Moriyama, Tetsuya Wakabayashi, Eriko Tanaka, Atsushi Muto, Tetsuo Kojima, Takehisa Kitazawa, Kazutaka Yoshihashi, Aya Harada, Miho Funaki, Kenta Haraya, Tatsuhiko Tachibana, Sachiyo Suzuki, Keiko Esaki, Yoshiaki Nabuchi, Kunihiro Hattori
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57479 (2013)
In hemophilia A, routine prophylaxis with exogenous factor VIII (FVIII) requires frequent intravenous injections and can lead to the development of anti-FVIII alloantibodies (FVIII inhibitors). To overcome these drawbacks, we screened asymmetric bisp
Externí odkaz:
https://doaj.org/article/9f57fabaafda4b53b4d59a5865060934
Publikováno v:
Mass Spectrometry
Ion mobility experiments coupled with electrospray ionization (ESI) were conducted to evaluate the folding states of bovine carbonic anhydrase 2 (CA2) under three different pH conditions. Collision cross-section (CCS) of the CA2 ions generated by ESI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e1b27dd6b3bdaea6ec71b9f8c292fa
http://europepmc.org/articles/PMC5832482
http://europepmc.org/articles/PMC5832482
Publikováno v:
Journal of the Mass Spectrometry Society of Japan. 60:47-50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e4b07ec024068195740334b052b5b2d
https://doi.org/10.5702/massspec.12-36
https://doi.org/10.5702/massspec.12-36
Publikováno v:
Analytical Chemistry. 82:8890-8896
Folding analysis of the zinc protein, carbonic anhydrase 2 (CA2), was performed using electrospray ionization ion mobility spectrometry coupled with collision-induced dissociation (ESI IMS/CID). Multiply protonated ions with a bimodal charge state di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02511ab362b225488b12cd9bb08d1ef8
https://doi.org/10.1021/ac101482b
https://doi.org/10.1021/ac101482b
Autor:
Yoshinori Aso, Masaki Ishigai, Kenji Takanashi, Motohiro Kato, Tetsuya Mitsui, Nobuo Sekiguchi, Atsuko Higashida, Yoshiaki Nabuchi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 24:500-510
Summary: A method of assessing the risk of drug-drug interaction (DDI) caused by mechanism-based inhibition (MBI) was developed for early-stage drug development using cytochrome P450 (CYP) 3A4 inhibition screening data. CYP3A4 inhibition was evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a1f9faee2b8b52180c4d55e9729bb9
https://doi.org/10.2133/dmpk.24.500
https://doi.org/10.2133/dmpk.24.500
Autor:
Ryoichi Saitoh, Noriyuki Takata, Tatsuhiko Tachibana, Yoshiaki Nabuchi, Yoshinori Aso, Atsuko Higashida, Kiyohiko Sugano
Publikováno v:
Pharmaceutical Research. 21:749-755
To improve predictions of fraction dose absorbed (Fa) for hydrophilic drugs, a correction of paracellular permeability using the pore radius of tight junctions (TJs) in Caco-2 monolayers was performed.The apparent permeability coefficient (P9app)) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f77a8674fc8b4c7ce86e5f35831c19a
https://doi.org/10.1023/b:pham.0000026423.48583.e2
https://doi.org/10.1023/b:pham.0000026423.48583.e2
Publikováno v:
International Journal of Pharmaceutics. 257:245-251
The purpose of the present study was to examine a correlation between the human intestinal permeability (P(eff)) and the bio-mimetic artificial membrane permeability corrected by the paracellular pathway model based on the Renkin function (P(PAMPA-PP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7790c5ff901c0df59aed7a24940168
https://doi.org/10.1016/s0378-5173(03)00161-3
https://doi.org/10.1016/s0378-5173(03)00161-3
Autor:
Shoshin Yoshida, Kiyohiko Sugano, Masayuki Haramura, Hidetoshi Ushio, Mikio Takaku, Ryoichi Saitoh, Yoshiaki Nabuchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1939-1942
The intestinal permeability of benzamidine analogue thrombin inhibitor is correlated with molecular volume, lipophilicity (calculated log P and IAM column capacity factor), hydrogen bond acidity/basicity and dipolarity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d97edbcf614b9be558624d06cc3b9a
https://doi.org/10.1016/s0960-894x(00)00367-x
https://doi.org/10.1016/s0960-894x(00)00367-x