Zobrazeno 1 - 10 of 132 pro vyhledávání: '"Yoshiaki Masuda"'
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Akademický článek
DLiP-PPI library: An integrated chemical database of small-to-medium-sized molecules targeting protein–protein interactions
Autor: Kazuyoshi Ikeda, Yuta Maezawa, Tomoki Yonezawa, Yugo Shimizu, Toshiyuki Tashiro, Satoru Kanai, Nobuyoshi Sugaya, Yoshiaki Masuda, Naoko Inoue, Tatsuya Niimi, Keiichi Masuya, Kenji Mizuguchi, Toshio Furuya, Masanori Osawa
Publikováno v: Frontiers in Chemistry, Vol 10 (2023)
Protein–protein interactions (PPIs) are recognized as important targets in drug discovery. The characteristics of molecules that inhibit PPIs differ from those of small-molecule compounds. We developed a novel chemical library database system (DLiP
Externí odkaz: https://doaj.org/article/42cbdb75873e4e278b556cd412d3723b
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4
Discovery of a New STAT3 Inhibitor Acting on the Linker Domain
Autor: Akira Asai, Naoya Suehiro, Yoshiaki Masuda, Daisuke Muraoka, Tatsuya Koseki, Naohisa Ogo, Nao Miyoshi
Publikováno v: Biologicalpharmaceutical bulletin. 42(5)
Signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor that contributes to tumor cell growth and survival and is often constitutively active in several types of cancers, which makes it an attractive target for can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c8697cfb32679c1411e53b691f053f
https://pubmed.ncbi.nlm.nih.gov/31061322
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Identification of a New Series of STAT3 Inhibitors by Virtual Screening
Autor: Akira Asai, Takane Yokotagawa, Sachiko Tai, Osamu Takahashi, Tadashi Okawara, Hiroshi Sato, Ayumu Muroya, Yasuto Akiyama, Chie Oshita, Masami Otsuka, Yoshiaki Masuda, Tadashi Ashizawa, Yutaka Uehara, Kenji Matsuno, Hidee Ishii, Toshio Furuya, Naohisa Ogo
Publikováno v: ACS Medicinal Chemistry Letters. 1:371-375
The signal transducer and activator of transcription 3 (STAT3) is considered to be an attractive therapeutic target for oncology drug development. We identified a N-[2-(1,3,4-oxadiazolyl)]-4-quinolinecarboxamide derivative, STX-0119, as a novel STAT3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd699a3088b69c9cd94c74b7f57b9a32
https://doi.org/10.1021/ml1000273
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7
In Silico Approaches for Fragment-based Drug Design
Autor: Toshio Furuya, Yoshiaki Masuda, Ayumu Muroya, Osamu Takahashi
Publikováno v: YAKUGAKU ZASSHI. 130:349-354
An important step to promote fragment-based drug design (FBDD) is to find high-quality fragment molecules. Therefore the design of the fragment library is the most crucial stage. In our fragment library, the main considerations are ligand efficiency
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20b2c0fe2fab8d52986131a60b25ce41
https://doi.org/10.1248/yakushi.130.349
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8
Fabrication and properties of perovskite Pb(Yb,Nb)O3–PbTiO3 thin films through a sol–gel process
Autor: Toshinobu Yogo, Wataru Sakamoto, Yoshiaki Masuda
Publikováno v: Journal of Alloys and Compounds. :543-546
Crack-free Pb(Yb 1/2 Nb 1/2 )O 3 –PbTiO 3 (PYN–PT) thin films have been fabricated by the chemical solution deposition. Homogeneous and stable PYN–PT precursor solutions were prepared by selecting appropriate starting metal-organic compounds an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07f9a35e1ead0a9b434a548c7c0e5c16
https://doi.org/10.1016/j.jallcom.2004.12.109
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Aortic Calcification Detected in a Mass Chest Screening Program Using a Mobile Helical Computed Tomography Unit-Relationship to Risk Factors and Coronary Artery Disease
Autor: Yoshiaki Masuda, Yasutaka Itani, Shigeru Watanabe
Publikováno v: Circulation Journal. 68:538-541
Background There is a significant relationship between calcification of the aortic arch (Arch) detected by chest X-ray examination and coronary artery disease (CAD), but the relationship between risk factors, CAD and aortic calcification detected dur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcb3463f5d15adf95bc88f51427c3067
https://doi.org/10.1253/circj.68.538
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