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of 3
pro vyhledávání: '"Yoshiaki Kirigaya"'
Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects
Autor:
Yoshiaki Kirigaya, Masanari Shiramoto, Tomoko Ishizuka, Hinako Uchimaru, Shin Irie, Manabu Kato, Takako Shimizu, Takafumi Nakatsu, Yasuhiro Nishikawa, Hitoshi Ishizuka
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin. Methods In three open-label, single-sequence, crossover studies, hea
Externí odkaz:
https://doaj.org/article/c39e71805f0e44b8b24ece08b36c520b
Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects
Autor:
Takafumi Nakatsu, Masanari Shiramoto, Yoshiaki Kirigaya, Takako Shimizu, Shin Irie, Tomoko Ishizuka, Yasuhiro Nishikawa, Hinako Uchimaru, Hitoshi Ishizuka, Manabu Kato
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
Background To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin. Methods In three open-label, single-sequence, crossover studies, healthy Japa
Autor:
Takafumi Nakatsu, Hitoshi Ishizuka, Takako Shimizu, Tomoko Ishizuka, Shin Irie, Manabu Kato, Hinako Uchimaru, Yasuhiro Nishikawa, Masanari Shiramoto, Yoshiaki Kirigaya
Publikováno v:
British Journal of Clinical Pharmacology
Aims To investigate the effects of the strong cytochrome P450 (CYP) 3A inhibitor itraconazole and the strong CYP3A inducer rifampicin on the pharmacokinetics of single-dose esaxerenone, a nonsteroidal mineralocorticoid receptor blocker, in healthy Ja