Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Yoshiaki Kikkawa"'
Autor:
Sakiko Toyama, Tomoko Honda, Sadahiro Iwabuchi, Shinichi Hashimoto, Kenzaburo Yamaji, Yuko Tokunaga, Yusuke Matsumoto, Hideya Kawaji, Takashi Miyazaki, Yoshiaki Kikkawa, Michinori Kohara
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Intranasal vaccines that elicit mucosal immunity are deemed effective against respiratory tract infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but their ability to induce humoral immunity characterized by immunoglobu
Externí odkaz:
https://doaj.org/article/36f123777df6497f99fe3e9525a11e9a
Autor:
Shumpei P. Yasuda, Yuki Miyasaka, Xuehan Hou, Yo Obara, Hiroshi Shitara, Yuta Seki, Kunie Matsuoka, Ai Takahashi, Eri Wakai, Hiroshi Hibino, Toyoyuki Takada, Toshihiko Shiroishi, Ryo Kominami, Yoshiaki Kikkawa
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2221 (2022)
An MSM/Ms strain was established using Japanese wild mice, which exhibit resistance to several phenotypes associated with aging, such as obesity, inflammation, and tumorigenesis, compared to common inbred mouse strains. MSM/Ms strain is resistant to
Externí odkaz:
https://doaj.org/article/b75c825ab039479b8e28c8ba546586f6
Autor:
Takahiro Sanada, Yuichi Hirata, Yutaka Naito, Naoki Yamamoto, Yoshiaki Kikkawa, Yuji Ishida, Chihiro Yamasaki, Chise Tateno, Takahiro Ochiya, Michinori Kohara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 272-283 (2017)
Background & Aims: An extracellular vesicle (EV) is a nanovesicle that shuttles proteins, nucleic acids, and lipids, thereby influencing cell behavior. A recent crop of reports have shown that EVs are involved in infectious biology, influencing host
Externí odkaz:
https://doaj.org/article/7e01847223e2459084043aaacbf8b048
Autor:
Masao Horie, Kazuyuki Mekada, Hiromi Sano, Yoshiaki Kikkawa, Satomi Chiken, Takuro Someya, Keisuke Saito, M Ibrahim Hossain, Masaaki Nameta, Kuniya Abe, Kenji Sakimura, Katsuhiko Ono, Atsushi Nambu, Atsushi Yoshiki, Hirohide Takebayashi
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 271-283 (2016)
We identified a novel spontaneous mutant mouse showing motor symptoms that are similar to those of the dystonia musculorum (dt) mouse. The observations suggested that the mutant mice inherited the mild dt phenotype as an autosomal recessive trait. Li
Externí odkaz:
https://doaj.org/article/7de5d94cde7e44a5b8f6aa19a07c5e06
Autor:
Yuta Seki, Yuki Miyasaka, Sari Suzuki, Kenta Wada, Shumpei P Yasuda, Kunie Matsuoka, Yasuhiro Ohshiba, Kentaro Endo, Rie Ishii, Hiroshi Shitara, Shin-Ichiro Kitajiri, Naomi Nakagata, Hirohide Takebayashi, Yoshiaki Kikkawa
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183477 (2017)
An unconventional myosin encoded by the myosin VI gene (MYO6) contributes to hearing loss in humans. Homozygous mutations of MYO6 result in nonsyndromic profound congenital hearing loss, DFNB37. Kumamoto shaker/waltzer (ksv) mice harbor spontaneous m
Externí odkaz:
https://doaj.org/article/c1e4ee1bdd074964b8ea025c2bba01e6
Autor:
Kenta Wada, Yoshibumi Matsushima, Tomoki Tada, Sayaka Hasegawa, Yo Obara, Yasuhiro Yoshizawa, Gou Takahashi, Hiroshi Hiai, Midori Shimanuki, Sari Suzuki, Junichi Saitou, Naoki Yamamoto, Masumi Ichikawa, Kei Watanabe, Yoshiaki Kikkawa
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111432 (2014)
Microphthalmia is a severe ocular disorder, and this condition is typically caused by mutations in transcription factors that are involved in eye development. Mice carrying mutations in these transcription factors would be useful tools for defining t
Externí odkaz:
https://doaj.org/article/06646f858edb4fc3a91f62cd2ce2d139
Autor:
Takayuki Mito, Yoshiaki Kikkawa, Akinori Shimizu, Osamu Hashizume, Shun Katada, Hirotake Imanishi, Azusa Ota, Yukina Kato, Kazuto Nakada, Jun-Ichi Hayashi
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55789 (2013)
Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes accele
Externí odkaz:
https://doaj.org/article/26e751ffb9a34aad969369972af64f56
Autor:
Kunie Matsuoka, Hiroshi Shitara, Choji Taya, Kenji Kohno, Yoshiaki Kikkawa, Hiromichi Yonekawa
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60958 (2013)
Basophils and eosinophils play important roles in various host defense mechanisms but also act as harmful effectors in allergic disorders. We generated novel basophil- and eosinophil-depletion mouse models by introducing the human diphtheria toxin (D
Externí odkaz:
https://doaj.org/article/c7ffc28a38a14e35bf70b8ad2366cb8e
Autor:
Hirotake Imanishi, Gaku Takibuchi, Toshihiko Kobayashi, Kaori Ishikawa, Kazuto Nakada, Masayuki Mori, Yoshiaki Kikkawa, Keizo Takenaga, Noriko Toyama-Sorimachi, Jun-Ichi Hayashi
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75981 (2013)
In mammalian species, mitochondrial DNA (mtDNA) with pathogenic mutations that induce mitochondrial respiration defects has been proposed to be involved in tumor phenotypes via induction of enhanced glycolysis under normoxic conditions (the Warburg e
Externí odkaz:
https://doaj.org/article/3f956d1b06b14a1ea8aabea631650e76
Autor:
Kei Watanabe, Kenta Wada, Tomoko Ohashi, Saki Okubo, Kensuke Takekuma, Ryoichi Hashizume, Jun-Ichi Hayashi, Tadao Serikawa, Takashi Kuramoto, Yoshiaki Kikkawa
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50737 (2012)
We discovered a new cataract mutation, kfrs4, in the Kyoto Fancy Rat Stock (KFRS) background. Within 1 month of birth, all kfrs4/kfrs4 homozygotes developed cataracts, with severe opacity in the nuclei of the lens. In contrast, no opacity was observe
Externí odkaz:
https://doaj.org/article/32c5807dc6b440f4859c675debee5363