Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Yoshiaki Kido"'
Autor:
Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida, Masaaki Uematsu, Kazuki Nakao, Harumi Nakao, Atsu Aiba, Yoji Nagashima, Tetsuya Kubota, Naoto Kubota, Yoshihiko Izumida, Naoya Yahagi, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Shun-ichiro Asahara, Yoshiaki Kido, Hideo Shindou, Michiko Itoh, Yoshihiro Ogawa, Shiro Minami, Yasuo Terauchi, Kazuyuki Tobe, Kohjiro Ueki, Masato Kasuga, Michihiro Matsumoto
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes are interacting comorbidities of obesity, and increased hepatic de novo lipogenesis (DNL), driven by hyperinsulinemia and carbohydrate overload, contributes to their pathogenesis. Fatty aci
Externí odkaz:
https://doaj.org/article/e5ab1c9c4a954f56823c71beefd37326
Publikováno v:
Diabetes & Metabolism Journal, Vol 46, Iss 1, Pp 38-48 (2022)
The main pathogenic mechanism of diabetes consists of an increase in insulin resistance and a decrease in insulin secretion from pancreatic β-cells. The number of diabetic patients has been increasing dramatically worldwide, especially in Asian peop
Externí odkaz:
https://doaj.org/article/a51e1bb47cf04097a2544e7d106505c0
Autor:
Guirong Han, Harumi Takahashi, Naoya Murao, Ghupurjan Gheni, Norihide Yokoi, Yoshiyuki Hamamoto, Shun‐ichiro Asahara, Yutaka Seino, Yoshiaki Kido, Susumu Seino
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 6, Pp 920-930 (2021)
Abstract Aims/Introduction Glutamine is the most abundant amino acid in the circulation. In this study, we investigated cell signaling in the amplification of insulin secretion by glutamine. Materials and Methods Clonal pancreatic β‐cells MIN6‐K
Externí odkaz:
https://doaj.org/article/5f31d8d422264d359df183cf9bac2a7e
Autor:
Hiroyuki Inoue, Mayumi Saito, Kumiko Kouchi, Shun‐ichiro Asahara, Fumihiko Nakamura, Yoshiaki Kido
Publikováno v:
Journal of Diabetes Investigation, Vol 11, Iss 4, Pp 938-945 (2020)
Abstract Aims/Introduction Mean platelet volume (MPV) is a widely used biological marker of platelet function and activity. Increased MPV is associated with accelerated thrombopoiesis and an elevated risk of cardiovascular disease. However, it is not
Externí odkaz:
https://doaj.org/article/0ba8eaeefe504d368d9b67cf04f1cd88
Autor:
Ayumi Kanno, Shun‐ichiro Asahara, Mao Kawamura, Ayuko Furubayashi, Shoko Tsuchiya, Emi Suzuki, Tomoko Takai, Maki Koyanagi‐Kimura, Tomokazu Matsuda, Yuko Okada, Wataru Ogawa, Yoshiaki Kido
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 3, Pp 577-590 (2019)
Abstract Aims/Introduction The preservation of pancreatic β‐cell mass is an essential factor in the onset and development of type 2 diabetes mellitus. Recently, sodium–glucose cotransporter 2 inhibitors have been launched as antihyperglycemic ag
Externí odkaz:
https://doaj.org/article/b711612df1694e469d44da4753bd2f48
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 614 (2022)
Pancreatic β-cells are the only type of cells that can control glycemic levels via insulin secretion. Thus, to explore the mechanisms underlying pancreatic β-cell failure, many reports have clarified the roles of important molecules, such as the me
Externí odkaz:
https://doaj.org/article/0e5a98fb9d5e437fa080836ec412d4af
Autor:
Atsuko Katsuyama, Shun-Ichiro Asahara, Shun-Ichiro Nakai, Hisanori Imai, Yoshiaki Kido, Wataru Ogawa
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
ObjectiveTo evaluate the usefulness of en face slab optical coherence tomography (OCT) imaging for monitoring diabetic retinal neurodegeneration with supporting animal experimental data.Research design and methodsWe retrospectively examined 72 diabet
Externí odkaz:
https://doaj.org/article/350d8757cbc24f4ab2d7c899aff5a476
Autor:
Atsuko Katsuyama, Shun-Ichiro Asahara, Shun-Ichiro Nakai, Hisanori Imai, Yoshiaki Kido, Wataru Ogawa
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
IntroductionThe Diabetes Symptom Checklist-Revised (DSC-R) is a well-validated patient-reported outcome designed to assess symptom burden in persons with type 2 diabetes mellitus (T2DM) across eight domains. The DSC-R has so far primarily been used i
Externí odkaz:
https://doaj.org/article/0931477b32f3449fa9a4822725979b87
Autor:
Mashito Sakai, Tomoko Tujimura-Hayakawa, Takashi Yagi, Hiroyuki Yano, Masaru Mitsushima, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Hiroshi Inoue, Yoshiaki Kido, Masato Kasuga, Michihiro Matsumoto
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
GCN5 inhibits hepatic gluconeogenesis through acetylation of PGC-1α. Here the authors show that GCN5 also activates hepatic gluconeogenesis by acetylating histone H3K9, and that the affinity of GCN5 for its different substrates is regulated via phos
Externí odkaz:
https://doaj.org/article/8001c64b252745a788bee1e6cfee26e3
Autor:
Kumi Kimura, Mamoru Tanida, Naoto Nagata, Yuka Inaba, Hitoshi Watanabe, Mayumi Nagashimada, Tsuguhito Ota, Shun-ichiro Asahara, Yoshiaki Kido, Michihiro Matsumoto, Koji Toshinai, Masamitsu Nakazato, Toshishige Shibamoto, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2362-2374 (2016)
Central insulin action activates hepatic IL-6/STAT3 signaling, which suppresses the gene expression of hepatic gluconeogenic enzymes. The vagus nerve plays an important role in this centrally mediated hepatic response; however, the precise mechanism
Externí odkaz:
https://doaj.org/article/4ece7d92e4724e31a995e093378b94c3