Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Yoshiaki Isobe"'
Autor:
Shingo Tojo, Zhikuan Zhang, Hiroyuki Matsui, Masahiro Tahara, Mitsunori Ikeguchi, Mami Kochi, Mami Kamada, Hideki Shigematsu, Akihisa Tsutsumi, Naruhiko Adachi, Takuma Shibata, Masaki Yamamoto, Masahide Kikkawa, Toshiya Senda, Yoshiaki Isobe, Umeharu Ohto, Toshiyuki Shimizu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
A series of Toll-like receptor 7 (TLR7)-specific antagonists and extensive structural analysis reveal the open conformation of the receptor and the structural basis of TLR7 antagonism. One of the compounds shows efficacy in treating mouse model of sy
Externí odkaz:
https://doaj.org/article/be81925ea7f144b39dd225d5ffceb7a8
Autor:
Masahide Kikkawa, Mitsunori Ikeguchi, Masaki Yamamoto, Umeharu Ohto, Toshiyuki Shimizu, Akihisa Tsutsumi, Toshiya Senda, Shingo Tojo, Yoshiaki Isobe, Mami Kamada, Hideki Shigematsu, Mami Kochi, Takuma Shibata, Z. Zhang, Hiroyuki Matsui, Naruhiko Adachi, Masahiro Tahara
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Toll-like receptor 7 (TLR7) recognizes both microbial and endogenous RNAs and nucleosides. Aberrant activation of TLR7 has been implicated in several autoimmune diseases including systemic lupus erythematosus (SLE). Here, by modifying potent TLR7 ago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c459518c31964251e11aa45e111f262
https://doaj.org/article/be81925ea7f144b39dd225d5ffceb7a8
https://doaj.org/article/be81925ea7f144b39dd225d5ffceb7a8
Autor:
Hitoshi Watanabe, Kyoji Ishida, Yoshiaki Isobe, Masakuni Horiguchi, Tomokazu Nakako, Masanori Yamamoto
Publikováno v:
Bioorganicmedicinal chemistry letters. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324c7623f4d55e6981f0860acb95813c
https://pubmed.ncbi.nlm.nih.gov/33691168
https://pubmed.ncbi.nlm.nih.gov/33691168
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(21)
Clozapine-like compound without agranulocytosis risk is need to cure the treatment resistant schizophrenia (TRS). We discovered (S)-3 as Clozapine-like dopamine D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::200186f76bd4233f6bc373609833b4d1
https://pubmed.ncbi.nlm.nih.gov/32976928
https://pubmed.ncbi.nlm.nih.gov/32976928
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 44:128115
Kynurenine monooxygenase (KMO) is expected to be a good drug target to treat Huntington's disease (HD). This study presents the structure-activity relationship of pyridazine derivatives to find novel KMO inhibitors. The most promising compound 14 res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375ddeb5768db8eed4d7c0bd60b226ef
https://doi.org/10.1016/j.bmcl.2021.128115
https://doi.org/10.1016/j.bmcl.2021.128115
Autor:
Mari Miyajima, Mika Endo, Yoko Deai, Momoe Kassai, Hitoshi Suda, Masahiro Yahata, Yoshiaki Isobe, Hidenori Kimura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 33:127753
Huntington's disease (HD) is one of the serious neurodegenerative diseases and no disease modifiers are available to date. The correction of unbalanced kynurenine pathway metabolites may be useful to treat disease progression and kynurenine monooxyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dfaa8c8e5fb195414e5d61a2dbd507
https://doi.org/10.1016/j.bmcl.2020.127753
https://doi.org/10.1016/j.bmcl.2020.127753
Autor:
Masanori Tobe, Norio Fujiwara, Masakazu Isobe, Katsunori Tsuboi, Futoshi Hasegawa, Yoshiaki Isobe, Yoshifumi Inoue
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1292-1295
We have designed and efficiently synthesized novel 1-phenyl-6-aminouracils by replacing the chroman moiety in CX-659S, a nonsteroidal dermatologic candidate, with dimethyldihydrobenzofuranol to cancel CX-659S asymmetric center. Medicinal chemistry ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c9fad4d05a6ede972b654a37a6f226
https://doi.org/10.1016/j.bmcl.2016.01.019
https://doi.org/10.1016/j.bmcl.2016.01.019
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127563
Clozapine-like compound without agranulocytosis risk is need to cure the treatment resistant schizophrenia (TRS). We discovered (S)-3 as Clozapine-like dopamine D2/D1 receptor selectivity and improved reactive metabolites formation profile by the mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::574c9bf6e22c391a128bd3da00d08fab
https://doi.org/10.1016/j.bmcl.2020.127563
https://doi.org/10.1016/j.bmcl.2020.127563
Publikováno v:
The Proceedings of Conference of Kansai Branch. :P022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c9b2795b9da8b65383c595cd9bf7116
https://doi.org/10.1299/jsmekansai.2019.94.p022
https://doi.org/10.1299/jsmekansai.2019.94.p022
Autor:
Shogo Nakatani, Shigehiro Asano, Erina Koga, Yoshiaki Isobe, Nobuyuki Koike, Masafumi Komiya, Junetsu Igarashi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 61:1094-1097
Based on the structure activity relationship of 2-(4-phenoxybenzoyl)-5-hydroxyindole (1), a novel structural class of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibitors were synthesized. We show in this study that the acidic proton at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8befc4d4bb879d1166cae57d59d762f
https://doi.org/10.1248/cpb.c13-00493
https://doi.org/10.1248/cpb.c13-00493