Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yoshiaki Hosohata"'
Autor:
Yoshiaki Hosohata, Frank Porreca, Henry I. Yamamura, Carl J. Kovelowski, George R. Uhl, Michael H. Ossipov, Josephine Lai, Todd W. Vanderah, Thomas H Burkey, Kenner C. Rice, Victor J. Hruby, William R. Roeske, Ichiro Sora, Xiaoyan Zhang
Publikováno v:
European Journal of Pharmacology. 388:241-248
We examined the effects of [ d -Pen 2 , d -Pen 5 ]enkephalin (DPDPE), [ d -Ala 2 ,Glu 4 ]deltorphin (DELT), and (+)-4-[(α R )-α((2 S ,5 R )-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N , N -diethylbenzamide (SNC80) on [ 35 S]GTPγS bindi
Autor:
Takashi Nakamura, Kenichi Watanabe, Toshio Ohnuki, Takafumi Nagatomo, Ikunobu Muramatsu, Jun Suzuki, Yoshiaki Hosohata, Kaoru Hattori
Publikováno v:
Pharmacology. 59:183-191
The dissociating and/or residual inhibitory effects of bopindolol from β-adrenoceptors (ARs) of atria strips pretreated with this drug and washed out with buffers on isoprenaline-induced chronotropic actions were determined. The effects of this drug
Autor:
F Porreca, Thomas H Burkey, Eva V. Varga, Frederick J. Ehlert, Keiko Hosohata, Scott Cowell, Henry I. Yamamura, Xiaoping Li, Hiroshi Nagase, William R. Roeske, Dagmar Stropova, Victor J. Hruby, Yoshiaki Hosohata, Cheryl A. Slate, Raymond M. Quock
Publikováno v:
Life Sciences. 62:1531-1536
Delta-opioid receptor-selective drugs may provide an alternative to mu-opioid-selective drugs currently used for the relief of pain. To develop improved delta-opioid receptor-selective drugs, better measures of drug activity are necessary. In this re
Autor:
Yoshiaki Hosohata, Masahiro Okuyama, Kaoru Hattori, Takafumi Nagatomo, Toshio Ohnuki, Yang Shen, Hiroyuki Kaneko, Jun Suzuki
Publikováno v:
Pharmacology. 57:180-187
The dissociating and/or residual inhibitory effects of bopindolol from β-adrenoceptors of atria strips pretreated with this drug which was then washed out with buffers on the responses to isoprenaline were determined and compared with those of propr
Autor:
Keiko Maruyama, Takafumi Nagatomo, Kenichi Watanabe, Jun Suzuki, Yoshiaki Hosohata, Kaoru Hattori, Keiko Sasaki, Toshio Ohnuki
Publikováno v:
Biological and Pharmaceutical Bulletin. 19:932-935
The effects of the chronic administration of bopindolol on the binding characteristics of [3H]CGP12177 and [3H]prazosin to cardiac α1H-, α1L-, β1- and β2-adrenoceptor subtypes of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) w
Publikováno v:
British Journal of Pharmacology. 108:484-489
1. The specificity of betaxolol, a beta-adrenoceptor antagonist, for beta 1- and beta 2-adrenoceptors was compared with that of other beta-antagonists, atenolol, ICI-118551, butoxamine and (+/-)-propranolol, in the bovine trachea and heart by competi
Autor:
Alexandros Makriyannis, Keiko Hosohata, Raymond M. Quock, Paul Consroe, William R. Roeske, Yoshiaki Hosohata, Henry I. Yamamura
Publikováno v:
European Journal of Pharmacology. 321:R1-R3
This research was designed to determine the action of the novel aminoalkylindole AM630 (6-iodo-pravadoline) at the cannabinoid receptor by studying its interaction with the cannabinoid receptor agonist WIN 55,212-2 (R(+)-[2,3-dihydro-5-methyl-3-[(mor
The androgen receptor (AR) binds to and activates transcription of target genes in response to androgens. In an attempt to isolate cofactors capable of influencing AR transcriptional activity, we used an immunoprecipitation method and identified a 44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f719abae5167493b53c31100edcbe19
https://europepmc.org/articles/PMC193941/
https://europepmc.org/articles/PMC193941/
Publikováno v:
Biological and Pharmaceutical Bulletin. 17:1296-1298
Bopindolol and its two metabolites (18-502 and 20-785) were examined for their affinity to a beta 2-adrenoceptor in the bovine mesenteric artery using the radioligand binding assay method with [3H]CGP12177 as a radioligand. The Scatchard analysis of
Autor:
Eva V. Varga, Takashi Okura, Henry I. Yamamura, Kenner C. Rice, William R. Roeske, Scott Cowell, Hiroshi Nagase, Victor J. Hruby, Yoshiaki Hosohata, Edita Navratilova
Publikováno v:
European journal of pharmacology. 459(1)
Down-regulation of the delta-opioid receptor contributes to the development of tolerance to delta-opioid receptor agonists. The involvement of the carboxy terminus of the mouse delta-opioid receptor in peptide agonist-mediated down-regulation has bee