Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yoshiaki Hirashima"'
Autor:
M Igata, S Kodama, Kohjiro Ueki, E. Araki, K Tsuruzoe, Tetsushi Toyonaga, Yoshiaki Hirashima, C R Kahn
Publikováno v:
Journal of Endocrinology. 179:253-266
Insulin receptor substrate (IRS)-1 and IRS-2 are the major substrates that mediate insulin action. Insulin itself regulates the expression of the IRS protein in the liver, but the underlying mechanisms of IRS-1 and IRS-2 regulation are not fully unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b56db65860afad67b3236b73ac8ad2
https://doi.org/10.1677/joe.0.1790253
https://doi.org/10.1677/joe.0.1790253
Autor:
Tomohiro Usuku, Shinsaku Imashuku, Hisaichi Fujii, Ikuyo Ueda, Shinjiro Todo, Gen Kano, Yoshiaki Hirashima, Kikuko Kuriyama, Akira Morimoto, Yasuko Sawai, Tohru Sugimoto, Hitoshi Kanno
Publikováno v:
British Journal of Haematology. 122:1009-1013
We report the case of a 3-year-old Japanese boy with phosphoglycerate kinase 1 (PGK1) deficiency (Online Mendelian Inheritance in Man entry 311800). The patient had anaemia and jaundice at birth, necessitating exchange transfusions for 2 d. After one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7275b6fb11735280cb36e34b28d09611
https://doi.org/10.1046/j.1365-2141.2003.04543.x
https://doi.org/10.1046/j.1365-2141.2003.04543.x
Autor:
Yoshiaki Hirashima, Kaku Tsuruzoe, Eiichi Araki, Atsuhisa Shirakami, K. Sakai, Hiroyuki Motoshima, Tetsushi Toyonaga, Jyunji Kawashima
Publikováno v:
Diabetologia. 46:231-240
Resistin is a peptide secreted by adipocytes and recognized as a hormone that could link obesity to insulin resistance. This study was designed to examine the effect and mechanism(s) of insulin on resistin expression in 3T3-L1 adipocytes.Differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1496dba7c9d67b64f8b97562f4f1000
https://doi.org/10.1007/s00125-002-1022-3
https://doi.org/10.1007/s00125-002-1022-3
Autor:
Tetsushi Toyonaga, Atsuhisa Shirakami, Nobuhiro Miyamura, K Tsuruzoe, E. Araki, Tetsuya Shirotani, Kazuaki Yoshizato, Yoshiaki Hirashima, C R Kahn, J Kawashima, K. Matsumoto
Publikováno v:
Journal of Endocrinology. 174:309-319
Insulin receptor substrate 1 (IRS-1) gene polymorphisms have been identified in type 2 diabetic patients; however, it is unclear how such polymorphisms contribute to the development of diabetes. Here we introduced obesity in heterozygous IRS-1 knocko
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce96e4a3391a64dcc9c2ac526bc9f44d
https://doi.org/10.1677/joe.0.1740309
https://doi.org/10.1677/joe.0.1740309
Autor:
Tetsushi Toyonaga, Yousuke Ebina, Hiroyuki Motoshima, Tetsuya Taguchi, Noboru Furukawa, Kazuaki Yoshizato, Eiichi Araki, Yoshiaki Hirashima, Motoaki Shichiri, Junji Kawashima, Tetsuya Shirotani
Publikováno v:
Biochemical and Biophysical Research Communications. 280:428-434
The liver is a major target organ of insulin and is important for glucose homeostasis. We analyzed the tissue specific regulation of the insulin receptor gene in the liver by studying the cis-acting element and trans-acting factor of the human insuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce32bb6ad303f0e72f72a13aa2f8e93
https://doi.org/10.1006/bbrc.2000.4140
https://doi.org/10.1006/bbrc.2000.4140
Autor:
Akira, Morimoto, Ikuyo, Ueda, Yoshiaki, Hirashima, Yasuko, Sawai, Tomohiro, Usuku, Gen, Kano, Kikuko, Kuriyama, Shinjiro, Todo, Tohru, Sugimoto, Hitoshi, Kanno, Hisaichi, Fujii, Shinsaku, Imashuku
Publikováno v:
British journal of haematology. 122(6)
We report the case of a 3-year-old Japanese boy with phosphoglycerate kinase 1 (PGK1) deficiency (Online Mendelian Inheritance in Man entry 311800). The patient had anaemia and jaundice at birth, necessitating exchange transfusions for 2 d. After one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a012a42d0f4868856bb23eb54525953
https://pubmed.ncbi.nlm.nih.gov/12956773
https://pubmed.ncbi.nlm.nih.gov/12956773
Autor:
Koji Sakai, Kazuya Matsumoto, Yoshiaki Hirashima, Kenshi Ichinose, Eiichi Araki, Takeshi Nishikawa, Michael Brownlee, Tetsuya Shirotani, Kazuhiko Nakamaru, Junji Kawashima, Mihoshi Suefuji
Publikováno v:
Biochemical and biophysical research communications. 300(1)
Pancreatic beta-cells exposed to hyperglycemia produce reactive oxygen species (ROS). Because beta-cells are sensitive to oxidative stress, excessive ROS may cause dysfunction of beta-cells. Here we demonstrate that mitochondrial ROS suppress glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b130b0733621e7dfd1109d5236125cef
https://pubmed.ncbi.nlm.nih.gov/12480546
https://pubmed.ncbi.nlm.nih.gov/12480546
Autor:
Tetsuya Taguchi, Koji Sakai, Eiichi Araki, Kengo Kaneko, Hiroyuki Motoshima, Atsuhisa Shirakami, Junji Kawashima, Yoshiaki Hirashima, Kazuaki Yoshizato, Tetsuya Shirotani, Toshihiko Nishiyama, Motoaki Shichiri, Hideki Kishikawa
Publikováno v:
Diabetes research and clinical practice. 48(3)
We have previously shown that bradykinin potentiated insulin-induced glucose uptake through GLUT4 translocation in canine adipocytes and skeletal muscles. The aim of this study was to determine the molecular mechanism of bradykinin enhancement of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7b47e6c72b362f0ccf8f76693801f2
https://pubmed.ncbi.nlm.nih.gov/10802154
https://pubmed.ncbi.nlm.nih.gov/10802154