Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Yoshiaki, Onishi"'
Publikováno v:
Journal of Natural Products. 84:1882-1888
Withanolide derivatives have anticancer, anti-inflammatory, and other functions and are components of Indian traditional Ayurvedic medicine. Here, we found that 2,3-dihydro-3β-methoxy withaferin-A (3βmWi-A), a derivative of withaferin-A (Wi-A) belo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9933e29d36fa04bb9938de337d3cce
https://doi.org/10.1021/acs.jnatprod.0c01276
https://doi.org/10.1021/acs.jnatprod.0c01276
Publikováno v:
International Journal of Oral Science
International Journal of Oral Science, Vol 11, Iss 4, Pp 1-8 (2019)
International Journal of Oral Science, Vol 11, Iss 4, Pp 1-8 (2019)
The control of the circadian rhythm is important for health because it regulates physiological functions and is associated with health hazards. We aimed to identify a circadian biomarker of health status in human saliva, since collecting saliva is no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f9608355e2ed0ed061fe5dba10f6dc
https://pubmed.ncbi.nlm.nih.gov/31685794
https://pubmed.ncbi.nlm.nih.gov/31685794
Publikováno v:
Bioscience Reports
We have been investigating transcriptional regulation of the BMAL1 gene, a critical component of the mammalian clock system including DNA methylation. Here, a more detailed analysis of the regulation of DNA methylation of BMAL1 proceeded in RPMI8402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5364109db29430f87bbb27d8d9725d5e
http://europepmc.org/articles/PMC5437938
http://europepmc.org/articles/PMC5437938
Publikováno v:
Biochemical and Biophysical Research Communications. 443:339-343
The naphthoquinone pigment, shikonin, is a natural product derived from Lithospermum erythrorhizon and an active component of a Chinese traditional herbal therapeutic. We identified shikonin as a candidate for shortening the circadian period using re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250013b8c8c6a0fecf74fed5e1adde74
https://doi.org/10.1016/j.bbrc.2013.11.116
https://doi.org/10.1016/j.bbrc.2013.11.116
Publikováno v:
In Japanese Journal of Pharmacology 1999 79(2):177-183
Publikováno v:
Biochemical and Biophysical Research Communications. 440:449-453
We previously analyzed transcriptional regulation of the BMAL1 gene, a critical component of the mammalian clock system and found that the BMAL1 gene is expressed with circadian oscillation and that its regulatory region is located in hypomethylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de309fe9a7eb3b5c1f7077f8e200161
https://doi.org/10.1016/j.bbrc.2013.09.124
https://doi.org/10.1016/j.bbrc.2013.09.124
Autor:
Yoshiaki Onishi, Yasuhiro Kawano
Publikováno v:
Nucleic Acids Research
The Bmal1 gene is essential for the circadian system, and its promoter has a unique open chromatin structure. We examined the mechanism of topoisomerase I (Top1) to understand the role of the unique chromatin structure in Bmal1 gene regulation. Campt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17b556fdbd24d67d4e37176d0fce6f1
https://doi.org/10.1093/nar/gks779
https://doi.org/10.1093/nar/gks779
Publikováno v:
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B. 77:376-385
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c203770e1e01bd0444235687b4895e3
https://doi.org/10.1299/kikaib.77.376
https://doi.org/10.1299/kikaib.77.376
Autor:
Katsutaka Oishi, Yasuhiro Hara, Yoshiaki Onishi, Norio Ishida, Akiyoshi Fukamizu, Koyomi Miyazaki
Publikováno v:
Nucleic Acids Research
The circadian clock comprises transcriptional feedback loops of clock genes. Cryptochromes are essential components of the negative feedback loop in mammals as they inhibit CLOCK-BMAL1-mediated transcription. We purified mouse CRY1 (mCRY1) protein co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cbe73b03cbcc5a171ff1c7e575a8d2
https://doi.org/10.1093/nar/gkn1013
https://doi.org/10.1093/nar/gkn1013