Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Yoshiaki, Kamano"'
Autor:
Monica Ianosi-Irimie, Toshihiko Nogawa, Yoshiaki Kamano, G. Robert Pettit, Jules B. Puschett, Edd Rabon, Thomas E. Wiese, Hop V. Vu, Svitlana Danchuk
Publikováno v:
Experimental Biology and Medicine. 231:215-220
The study of the pathogenesis of preeclampsia has been hampered by a relative dearth of animal models. We developed a rat model of preeclampsia in which the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), is elevated. Thes
Autor:
Koichi Takeya, Mariko Katsuyama, Yoshiaki Kamano, Ayako Yukita, George R. Pettit, Toshiaki Segawa, Ayano Yamashita, Kyoko Saito, Hideji Itokawa, Hiroshi Morita, Toshihiko Nogawa
Publikováno v:
Journal of Medicinal Chemistry. 45:5440-5447
QSAR analysis has been used to identify the essential structural requirements for increasing the inhibitory activities of selected bufadienolides from the Chinese drug Ch'an Su (and other sources) against the primary liver carcinoma cell line PLC/PRF
Autor:
Akiko Fukami, Yoshino Sekiguchi, Tadashi Yanagisawa, Akiko Enomoto, Yoshiaki Kamano, Toshihiko Nogawa, Shinobu Nonaka, Mun-Chual Rho, Kanki Komiyama, Masahiko Hayashi, Ayano Yamashita
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:104-109
Interleukin (IL)-6 is a key mediator in the regulation and coordination of the immune response and participates in pathogenesis of cancer cachexia, autoimmune disease, and postmenopausal osteoporosis. In the course of a screening program aimed at IL-
Publikováno v:
Collection of Czechoslovak Chemical Communications. 66:1841-1848
The 1H and 13C NMR spectra of thirteen natural bufadienolides, which were isolated from the Chinese drug Ch'an Su, were assigned using a combination of 2D NMR spectra that included 1H-1H COSY, NOESY, HMQC, and HMBC techniques.
Autor:
Yoshiaki Kamano, Toshihiko Nogawa, Ayano Kotake, Hatsue Hiraide, Cherry L. Herald, George R. Pettit
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 23:399-409
The Separation of bryostatin derivatives (26-acetate, 26-metabromobenzoate, 26-ketone, and 13→ 30 epoxide) by high performance liquid chromatography (HPLC) using normal phase and reverse phase systems was accomplished. Using n-hexane/EtOAc/MeOH/H2O
Autor:
Hui-ping Zhang, Hirofumi Hashima, Ichiro Hayakawa, George R. Pettit, Kanki Komiyama, Ayano Kotake, Masahiko Hayashi, Haruhisa Kizu, Hatsue Hiraide, Yoshiaki Kamano
Publikováno v:
Collection of Czechoslovak Chemical Communications. 64:1147-1153
Two new (2-phenylethyl)amine alkaloids, convolutamines F and G, and a dibromohydroxyoxindole alkaloid, convolutamydine E, have been isolated from the butan-1-ol soluble material of the Floridian marine bryozoan Amathia convoluta. Their structures wer
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 22:2455-2465
We have examined the column chromatography using hydrophobic gel carriers, Sephadex LH-20 and HP-Cellulofine, for separation of ten toad poison bufadienolides: resibufogenin, cinobufagin, bufalin, bufotalin, cinobufotalin, telocinobufagin, desacetyl-
Autor:
George R. Pettit, Yoshiaki Kamano, Delbert L. Herald, Hideji Itokawa, Cherry L. Herald, Hui-ping Zhang, Osamu Shirota, Hiroshi Morita
Publikováno v:
Tetrahedron. 52:2369-2376
Conformation of bryostatin 10, a marine antineoplastic macrolide, in CDCl3 was analyzed by the spectroscopic and computational chemical methods. A combination of homonuclear two-dimensional NMR techniques at 600 MHz have enabled us to perform complet
Autor:
Yoshiaki Kamano, Jean-Charles Chapuis, John C. Coll, George R. Pettit, Jean M. Schmidt, Peter M. Blumberg, F. Gao, Cherry L. Herald, Nancy E. Lewin
Publikováno v:
Journal of Natural Products. 59:286-289
Separation of two trace cancer cell growth inhibitory (P388 leukemia) fractions from about 1000 kg of wet Gulf of Mexico Bugula neritina (Bryozoa) has led to the isolation of bryostatins 16-18 (2-4). A combination of HRFABMS and high-field (400 MHz)
Autor:
Yoshiaki Kamano, Jun-Ping Xu, Zbigniew A. Cichacz, Jayaram K. Srirangam, George R. Pettit, Jean M. Schmidt, Karen L. Erickson, Michael R. Boyd, Delbert L. Herald
Publikováno v:
The Journal of Organic Chemistry. 60:8257-8261