Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yoshi Nara"'
Autor:
Naohiro Taya, Chien-Hung Chen, Tsuneo Oda, Bi-Ching Sang, Tomoya Yukawa, Takayuki Sato, Yoshi Nara, Noriko Uchiyama, Zenyu Shiokawa, Terufumi Takagi, Satoshi Yamamoto, Ayumu Sato, Ryokichi Koyama, Nobuyuki Negoro, Gyorgy Snell, Junya Shirai, Ryosuke Katsuyama, Takashi Imada, Yoshihiro Banno, Isaac Hoffman, Tetsuji Kawamoto, Mitsunori Kono, Robert J. Skene
Publikováno v:
Journal of medicinal chemistry. 62(3)
Retinoic acid receptor-related orphan receptor γt (RORγt) agonists are expected to provide a novel class of immune-activating anticancer drugs via activation of Th17 cells and Tc17 cells. Herein, we describe a novel structure-based functionality sw
Autor:
Keiko Igaki, Yoshihiro Banno, Tsuneo Oda, Akira Shibata, Bi-Ching Sang, Masashi Yamasaki, Hideyuki Nakagawa, Atsuko Ochida, Hidekazu Tokuhara, Kazuko Yonemori, Junya Shirai, Satoshi Yamamoto, Yoshiyuki Fukase, Gyorgy Snell, Shinichi Masada, Tomoya Yukawa, Yoshi Nara, Isaac Hoffman, Tetsuji Kawamoto, Mitsunori Kono, Noboru Tsuchimori, Yoshiki Nakamura, Keiko Uga, Takashi Imada, Naohiro Taya, Robert J. Skene
Publikováno v:
Journal of medicinal chemistry. 61(7)
A series of tetrahydronaphthyridine derivatives as novel RORγt inverse agonists were designed and synthesized. We reduced the lipophilicity of tetrahydroisoquinoline compound 1 by replacement of the trimethylsilyl group and SBDD-guided scaffold exch
Autor:
Shinichi Imamura, Takehiro Iida, Yoshihiro Sugihara, Takashi Ichikawa, Naoyuki Kanzaki, Youichi Nishikawa, Yuji Iizawa, Osamu Kurasawa, Yoshi Nara, Masanori Baba, Shohei Hashiguchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:2295-2306
We have previously reported the novel lead compound 1a as a CCR5 antagonist for treatment of HIV-1 infection. SAR studies on incorporating various acyl groups as a replacement for the 5-oxopyrrolidine-3-carbonyl group of the lead structure resulted i
Autor:
Satoshi Sasaki, Masataka Harada, Masahiko Fujino, Satoshi Endo, Nobuhiro Suzuki, Shuichi Furuya, Yoshi Nara, Nobuo Cho
Publikováno v:
Journal of Medicinal Chemistry. 46:113-124
We have previously disclosed the first potent and orally effective non-peptide antagonist for the human luteinizing hormone-releasing hormone (LHRH) receptor, a thieno[2,3-b]pyridin-4-one derivative, T-98475 (1). Extensive research on developing non-
Autor:
Tetsuya Ohtani, Nobuo Cho, Yasushi Masuda, Shunichi Furuya, Yoshi Nara, Toshifumi Watanabe, Keiji Kusumoto, Akemi Abe, Tsukasa Sugo, Yasuaki Itoh, Mioko Harada
Publikováno v:
Chemical and Pharmaceutical Bulletin. 46:1724-1737
On the basis of structural information for the cyclic hexapeptide endothelin (ET) receptor antagonist, TAK-044, a series of thieno[2,3-d]pyrimidine-2,4-dione derivatives bearing a carboxyl group and aromatic rings that were important for receptor bin
Autor:
Mitsunori Kono, Atsuko Ochida, Tsuneo Oda, Takashi Imada, Yoshihiro Banno, Naohiro Taya, Shinichi Masada, Tetsuji Kawamoto, Kazuko Yonemori, Yoshi Nara, Yoshiyuki Fukase, Tomoya Yukawa, Hidekazu Tokuhara, Skene, Robert, Bi-Ching Sang, Hoffman, Isaac D., Snell, Gyorgy P., Keiko Uga, Akira Shibata, Keiko Igaki
Publikováno v:
Journal of Medicinal Chemistry; 4/12/2018, Vol. 61 Issue 7, p2973-2988, 16p