Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Yoshi Nara"'
Autor:
Naohiro Taya, Chien-Hung Chen, Tsuneo Oda, Bi-Ching Sang, Tomoya Yukawa, Takayuki Sato, Yoshi Nara, Noriko Uchiyama, Zenyu Shiokawa, Terufumi Takagi, Satoshi Yamamoto, Ayumu Sato, Ryokichi Koyama, Nobuyuki Negoro, Gyorgy Snell, Junya Shirai, Ryosuke Katsuyama, Takashi Imada, Yoshihiro Banno, Isaac Hoffman, Tetsuji Kawamoto, Mitsunori Kono, Robert J. Skene
Publikováno v:
Journal of medicinal chemistry. 62(3)
Retinoic acid receptor-related orphan receptor γt (RORγt) agonists are expected to provide a novel class of immune-activating anticancer drugs via activation of Th17 cells and Tc17 cells. Herein, we describe a novel structure-based functionality sw
Autor:
Keiko Igaki, Yoshihiro Banno, Tsuneo Oda, Akira Shibata, Bi-Ching Sang, Masashi Yamasaki, Hideyuki Nakagawa, Atsuko Ochida, Hidekazu Tokuhara, Kazuko Yonemori, Junya Shirai, Satoshi Yamamoto, Yoshiyuki Fukase, Gyorgy Snell, Shinichi Masada, Tomoya Yukawa, Yoshi Nara, Isaac Hoffman, Tetsuji Kawamoto, Mitsunori Kono, Noboru Tsuchimori, Yoshiki Nakamura, Keiko Uga, Takashi Imada, Naohiro Taya, Robert J. Skene
Publikováno v:
Journal of medicinal chemistry. 61(7)
A series of tetrahydronaphthyridine derivatives as novel RORγt inverse agonists were designed and synthesized. We reduced the lipophilicity of tetrahydroisoquinoline compound 1 by replacement of the trimethylsilyl group and SBDD-guided scaffold exch
Autor:
Shinichi Imamura, Takehiro Iida, Yoshihiro Sugihara, Takashi Ichikawa, Naoyuki Kanzaki, Youichi Nishikawa, Yuji Iizawa, Osamu Kurasawa, Yoshi Nara, Masanori Baba, Shohei Hashiguchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:2295-2306
We have previously reported the novel lead compound 1a as a CCR5 antagonist for treatment of HIV-1 infection. SAR studies on incorporating various acyl groups as a replacement for the 5-oxopyrrolidine-3-carbonyl group of the lead structure resulted i
Autor:
Satoshi Sasaki, Masataka Harada, Masahiko Fujino, Satoshi Endo, Nobuhiro Suzuki, Shuichi Furuya, Yoshi Nara, Nobuo Cho
Publikováno v:
Journal of Medicinal Chemistry. 46:113-124
We have previously disclosed the first potent and orally effective non-peptide antagonist for the human luteinizing hormone-releasing hormone (LHRH) receptor, a thieno[2,3-b]pyridin-4-one derivative, T-98475 (1). Extensive research on developing non-
Autor:
Tetsuya Ohtani, Nobuo Cho, Yasushi Masuda, Shunichi Furuya, Yoshi Nara, Toshifumi Watanabe, Keiji Kusumoto, Akemi Abe, Tsukasa Sugo, Yasuaki Itoh, Mioko Harada
Publikováno v:
Chemical and Pharmaceutical Bulletin. 46:1724-1737
On the basis of structural information for the cyclic hexapeptide endothelin (ET) receptor antagonist, TAK-044, a series of thieno[2,3-d]pyrimidine-2,4-dione derivatives bearing a carboxyl group and aromatic rings that were important for receptor bin
Autor:
Mitsunori Kono, Atsuko Ochida, Tsuneo Oda, Takashi Imada, Yoshihiro Banno, Naohiro Taya, Shinichi Masada, Tetsuji Kawamoto, Kazuko Yonemori, Yoshi Nara, Yoshiyuki Fukase, Tomoya Yukawa, Hidekazu Tokuhara, Skene, Robert, Bi-Ching Sang, Hoffman, Isaac D., Snell, Gyorgy P., Keiko Uga, Akira Shibata, Keiko Igaki
Publikováno v:
Journal of Medicinal Chemistry; 4/12/2018, Vol. 61 Issue 7, p2973-2988, 16p
Autor:
Carlos Rubio, Rumi Tani Moratalla
El Kojiki o Crónicas de antiguos hechos es la primera obra literaria de Japón. Aclamado como el gran relicario de los antiguos mitos, leyendas y canciones de la cultura japonesa, narra las tradiciones nacionales desde sus orígenes hasta el primer
Autor:
Paula Doe
This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Re
Treatise on Geomorphology, Second Edition, Eleven Volume Set is organized into eleven volumes built on the outstanding success of the first edition. This comprehensive introduction to the large and diverse discipline of geomorphology provides a key r
Autor:
Ryo Miyashita, Esin Esen
The academic discipline of translation studies is only half a century old and even younger in the field of bilateral translation between Japanese and Turkish. This book is the second volume of the world's first academic book on Turkish↔Japanese tra