Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Yoseph, Barash"'
Autor:
Jorge Vaquero-Garcia, Joseph K. Aicher, San Jewell, Matthew R. Gazzara, Caleb M. Radens, Anupama Jha, Scott S. Norton, Nicholas F. Lahens, Gregory R. Grant, Yoseph Barash
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Here the authors develop MAJIQ v2 to address challenges in detection, quantification, and visualization of RNA splicing variations from large heterogeneous RNA-Seq datasets. They then apply it to analyze 2,335 samples from 13 brain subregions.
Externí odkaz:
https://doaj.org/article/659b8c90e4764e15b37366776268b331
Autor:
David Wang, Mathieu Quesnel-Vallieres, San Jewell, Moein Elzubeir, Kristen Lynch, Andrei Thomas-Tikhonenko, Yoseph Barash
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
RNA splicing variations could help identify cancer subtypes, but this task is computationally challenging. Here, the authors develop CHESSBOARD, a Bayesian tile finding algorithm for splicing data which identifies patterns in the form of tiles and ca
Externí odkaz:
https://doaj.org/article/d9bf9b7fdf26407aa5c24b0f3bae250d
Autor:
Mariela Cortés-López, Laura Schulz, Mihaela Enculescu, Claudia Paret, Bea Spiekermann, Mathieu Quesnel-Vallières, Manuel Torres-Diz, Sebastian Unic, Anke Busch, Anna Orekhova, Monika Kuban, Mikhail Mesitov, Miriam M. Mulorz, Rawan Shraim, Fridolin Kielisch, Jörg Faber, Yoseph Barash, Andrei Thomas-Tikhonenko, Kathi Zarnack, Stefan Legewie, Julian König
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify
Externí odkaz:
https://doaj.org/article/c08d347a8dc943b8ab905da6ad76b36d
Autor:
Anupama Jha, Mathieu Quesnel-Vallières, David Wang, Andrei Thomas-Tikhonenko, Kristen W Lynch, Yoseph Barash
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-23 (2022)
Abstract Background Cancer is a set of diseases characterized by unchecked cell proliferation and invasion of surrounding tissues. The many genes that have been genetically associated with cancer or shown to directly contribute to oncogenesis vary wi
Externí odkaz:
https://doaj.org/article/4449558d4ff542678422511f8b71af41
Autor:
Olja Grgic, Matthew R. Gazzara, Alessandra Chesi, Carolina Medina-Gomez, Diana L. Cousminer, Jonathan A. Mitchell, Vid Prijatelj, Jard de Vries, Enisa Shevroja, Shana E. McCormack, Heidi J. Kalkwarf, Joan M. Lappe, Vicente Gilsanz, Sharon E. Oberfield, John A. Shepherd, Andrea Kelly, Soroosh Mahboubi, Fabio R. Faucz, Richard A. Feelders, Frank H. de Jong, Andre G. Uitterlinden, Jenny A. Visser, Louis R. Ghanem, Eppo B. Wolvius, Leo J. Hofland, Constantine A. Stratakis, Babette S. Zemel, Yoseph Barash, Struan F. A. Grant, Fernando Rivadeneira
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Olja Grgic, Matthew Gazzara, and Alessandra Chesi et al. perform a genome-wide association study meta-analysis for skeletal age in two pediatric cohorts. They observe that variation in the adrenal gene, CYP11B1, impacts its alternative splicing, sugg
Externí odkaz:
https://doaj.org/article/828a46ae925244b793f2682e780f9eb6
Autor:
Natoya J. Peart, Jae Yeon Hwang, Mathieu Quesnel-Vallières, Matthew J. Sears, Yuequin Yang, Peter Stoilov, Yoseph Barash, Juw Won Park, Kristen W. Lynch, Russ P. Carstens
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105205- (2022)
Summary: The epithelial splicing regulatory proteins, ESRP1 and ESRP2, are essential for mammalian development through the regulation of a global program of alternative splicing of genes involved in the maintenance of epithelial cell function. To fur
Externí odkaz:
https://doaj.org/article/c67b0c43228642c1bc61a396d81a760e
Autor:
Nicholas F. Lahens, Thomas G. Brooks, Dimitra Sarantopoulou, Soumyashant Nayak, Cris Lawrence, Antonijo Mrčela, Anand Srinivasan, Jonathan Schug, John B. Hogenesch, Yoseph Barash, Gregory R. Grant
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background The accurate interpretation of RNA-Seq data presents a moving target as scientists continue to introduce new experimental techniques and analysis algorithms. Simulated datasets are an invaluable tool to accurately assess the perfo
Externí odkaz:
https://doaj.org/article/e652ef326a1f48d3a154408788505a58
Autor:
Natoya J Peart, Taylor A Johnson, Sungkyoung Lee, Matthew J Sears, Fang Yang, Mathieu Quesnel-Vallières, Huijuan Feng, Yocelyn Recinos, Yoseph Barash, Chaolin Zhang, Brian P Hermann, P Jeremy Wang, Christopher B Geyer, Russ P Carstens
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010416 (2022)
Control over gene expression is exerted, in multiple stages of spermatogenesis, at the post-transcriptional level by RNA binding proteins (RBPs). We identify here an essential role in mammalian spermatogenesis and male fertility for 'RNA binding prot
Externí odkaz:
https://doaj.org/article/53361225d7ba4d6abbf2e4eaf7ec0fd2
Autor:
Xiaolei Liu, William D. Jones, Mathieu Quesnel-Vallières, Sudhish A. Devadiga, Kristin Lorent, Alexander J. Valvezan, Rebecca L. Myers, Ning Li, Christopher J. Lengner, Yoseph Barash, Michael Pack, Peter S. Klein
Publikováno v:
Journal of Developmental Biology, Vol 11, Iss 3, p 29 (2023)
Neural crest (NC) is a unique vertebrate cell type arising from the border of the neural plate and epidermis that gives rise to diverse tissues along the entire body axis. Roberto Mayor and colleagues have made major contributions to our understandin
Externí odkaz:
https://doaj.org/article/f1611d5c12b54d1ba12ab6eacd305385
Autor:
Laura Schulz, Manuel Torres-Diz, Mariela Cortés-López, Katharina E. Hayer, Mukta Asnani, Sarah K. Tasian, Yoseph Barash, Elena Sotillo, Kathi Zarnack, Julian König, Andrei Thomas-Tikhonenko
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Resistance to CD19-directed immunotherapies in lymphoblastic leukemia has been attributed, among other factors, to several aberrant CD19 pre-mRNA splicing events, including recently reported excision of a cryptic intron embedded within CD19
Externí odkaz:
https://doaj.org/article/7a025226aeea4eeeb954f32ea7752bb3